AU2328884A - Manufacture of beta-lactams - Google Patents

Manufacture of beta-lactams

Info

Publication number
AU2328884A
AU2328884A AU23288/84A AU2328884A AU2328884A AU 2328884 A AU2328884 A AU 2328884A AU 23288/84 A AU23288/84 A AU 23288/84A AU 2328884 A AU2328884 A AU 2328884A AU 2328884 A AU2328884 A AU 2328884A
Authority
AU
Australia
Prior art keywords
signifies
general formula
formula see
see diagramm
lactams
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU23288/84A
Other versions
AU566914B2 (en
Inventor
Gerard Schmid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU2328884A publication Critical patent/AU2328884A/en
Application granted granted Critical
Publication of AU566914B2 publication Critical patent/AU566914B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

1. A process for the manufacture of optically uniform beta -lactams of the general formula see diagramm : EP0116854,P10,F1 wherein R**1 signifies lower alkanoyl, lower alkoxycarbonyl or benzoyl, R**2 signifies hydrogen, lower alkyl, lower alkanoyl, lower alkoxycarbonyl or cyano, R**3 signifies hydrogen or lower alkyl, B signifies lower alkylidene, lower cycloalkylidene or carbonyl and Z signifies lower 2-alkenyl or 2,4-di(lower alkoxy)benzyl, whereby the residues denoted as lower have a maximum of 7 carbon atoms, and their corresponding optical antipodes, characterized by reacting a salt of a carboxylic acid of the general formula see diagramm : EP0116854,P10,F2 wherein R**1, R**3 have the above significance, in the presence of a reactive derivative of an organic sulphonic acid and a base with an optically uniform compound of the general formula see diagramm : EP0116854,P11,F3 wherein B and Z have the above significance, or the optical antipode thereof.
AU23288/84A 1983-01-20 1984-01-16 Manufacture of beta-lactams Ceased AU566914B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH320/83 1983-01-20
CH32083 1983-01-20

Publications (2)

Publication Number Publication Date
AU2328884A true AU2328884A (en) 1984-07-26
AU566914B2 AU566914B2 (en) 1987-11-05

Family

ID=4184333

Family Applications (1)

Application Number Title Priority Date Filing Date
AU23288/84A Ceased AU566914B2 (en) 1983-01-20 1984-01-16 Manufacture of beta-lactams

Country Status (13)

Country Link
EP (1) EP0116854B1 (en)
JP (1) JPS59137479A (en)
KR (1) KR840007230A (en)
AT (1) ATE37879T1 (en)
AU (1) AU566914B2 (en)
CA (1) CA1251454A (en)
DE (1) DE3474549D1 (en)
DK (1) DK24084A (en)
IE (1) IE56572B1 (en)
IL (1) IL70685A (en)
NZ (1) NZ206831A (en)
PH (1) PH19214A (en)
ZA (1) ZA84292B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU572194B2 (en) * 1983-10-03 1988-05-05 F. Hoffmann-La Roche Ag Azetidinone derivatives

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK36784A (en) * 1983-02-25 1984-08-26 Hoffmann La Roche PROCEDURE FOR PREPARING CHIRAL ALDEHYDES
US5395931A (en) * 1988-06-30 1995-03-07 Merck & Co., Inc. 6-amido-1-methyl-2-(substituted-thio)carbapenems
US5138050A (en) * 1988-06-30 1992-08-11 Merck & Co., Inc. 6-amido-1-methyl carbapenems

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1262128A (en) * 1981-08-27 1989-10-03 Christian N. Hubschwerlen .beta.-lactams
EP0096296B1 (en) * 1982-06-03 1987-07-29 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft 1-sulfo-2-oxoazetidine derivatives
CA1204746A (en) * 1982-08-19 1986-05-20 Hoffmann-La Roche Limited .beta. LACTAMS
DK36784A (en) * 1983-02-25 1984-08-26 Hoffmann La Roche PROCEDURE FOR PREPARING CHIRAL ALDEHYDES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU572194B2 (en) * 1983-10-03 1988-05-05 F. Hoffmann-La Roche Ag Azetidinone derivatives

Also Published As

Publication number Publication date
EP0116854A2 (en) 1984-08-29
DE3474549D1 (en) 1988-11-17
EP0116854A3 (en) 1984-12-05
DK24084D0 (en) 1984-01-19
ZA84292B (en) 1984-09-26
IE840114L (en) 1984-07-20
CA1251454A (en) 1989-03-21
DK24084A (en) 1984-07-21
KR840007230A (en) 1984-12-06
AU566914B2 (en) 1987-11-05
IL70685A0 (en) 1984-04-30
NZ206831A (en) 1987-04-30
JPS59137479A (en) 1984-08-07
PH19214A (en) 1986-02-04
EP0116854B1 (en) 1988-10-12
ATE37879T1 (en) 1988-10-15
IE56572B1 (en) 1991-09-11
IL70685A (en) 1988-09-30

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