AU566914B2 - Manufacture of beta-lactams - Google Patents

Manufacture of beta-lactams

Info

Publication number
AU566914B2
AU566914B2 AU23288/84A AU2328884A AU566914B2 AU 566914 B2 AU566914 B2 AU 566914B2 AU 23288/84 A AU23288/84 A AU 23288/84A AU 2328884 A AU2328884 A AU 2328884A AU 566914 B2 AU566914 B2 AU 566914B2
Authority
AU
Australia
Prior art keywords
signifies
general formula
formula see
see diagramm
lactams
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU23288/84A
Other versions
AU2328884A (en
Inventor
Gerard Schmid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU2328884A publication Critical patent/AU2328884A/en
Application granted granted Critical
Publication of AU566914B2 publication Critical patent/AU566914B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

1. A process for the manufacture of optically uniform beta -lactams of the general formula see diagramm : EP0116854,P10,F1 wherein R**1 signifies lower alkanoyl, lower alkoxycarbonyl or benzoyl, R**2 signifies hydrogen, lower alkyl, lower alkanoyl, lower alkoxycarbonyl or cyano, R**3 signifies hydrogen or lower alkyl, B signifies lower alkylidene, lower cycloalkylidene or carbonyl and Z signifies lower 2-alkenyl or 2,4-di(lower alkoxy)benzyl, whereby the residues denoted as lower have a maximum of 7 carbon atoms, and their corresponding optical antipodes, characterized by reacting a salt of a carboxylic acid of the general formula see diagramm : EP0116854,P10,F2 wherein R**1, R**3 have the above significance, in the presence of a reactive derivative of an organic sulphonic acid and a base with an optically uniform compound of the general formula see diagramm : EP0116854,P11,F3 wherein B and Z have the above significance, or the optical antipode thereof.
AU23288/84A 1983-01-20 1984-01-16 Manufacture of beta-lactams Ceased AU566914B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH32083 1983-01-20
CH320/83 1983-01-20

Publications (2)

Publication Number Publication Date
AU2328884A AU2328884A (en) 1984-07-26
AU566914B2 true AU566914B2 (en) 1987-11-05

Family

ID=4184333

Family Applications (1)

Application Number Title Priority Date Filing Date
AU23288/84A Ceased AU566914B2 (en) 1983-01-20 1984-01-16 Manufacture of beta-lactams

Country Status (13)

Country Link
EP (1) EP0116854B1 (en)
JP (1) JPS59137479A (en)
KR (1) KR840007230A (en)
AT (1) ATE37879T1 (en)
AU (1) AU566914B2 (en)
CA (1) CA1251454A (en)
DE (1) DE3474549D1 (en)
DK (1) DK24084A (en)
IE (1) IE56572B1 (en)
IL (1) IL70685A (en)
NZ (1) NZ206831A (en)
PH (1) PH19214A (en)
ZA (1) ZA84292B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK36784A (en) * 1983-02-25 1984-08-26 Hoffmann La Roche PROCEDURE FOR PREPARING CHIRAL ALDEHYDES
DK411384A (en) * 1983-10-03 1985-04-04 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF AZETIDINE UNDIVERIVES
US5138050A (en) * 1988-06-30 1992-08-11 Merck & Co., Inc. 6-amido-1-methyl carbapenems
US5395931A (en) * 1988-06-30 1995-03-07 Merck & Co., Inc. 6-amido-1-methyl-2-(substituted-thio)carbapenems

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8752382A (en) * 1981-08-27 1983-03-03 F. Hoffmann-La Roche Ag Azetidin-2-ones
AU1797983A (en) * 1982-08-19 1984-02-23 F. Hoffmann-La Roche Ag Beta-lactams
AU2474584A (en) * 1983-02-25 1984-08-30 F. Hoffmann-La Roche & Co. Process for the manufacture of chiral beta-lactams

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3372768D1 (en) * 1982-06-03 1987-09-03 Hoffmann La Roche 1-SULFO-2-OXOAZETIDINE DERIVATIVES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8752382A (en) * 1981-08-27 1983-03-03 F. Hoffmann-La Roche Ag Azetidin-2-ones
AU1797983A (en) * 1982-08-19 1984-02-23 F. Hoffmann-La Roche Ag Beta-lactams
AU2474584A (en) * 1983-02-25 1984-08-30 F. Hoffmann-La Roche & Co. Process for the manufacture of chiral beta-lactams

Also Published As

Publication number Publication date
DK24084A (en) 1984-07-21
AU2328884A (en) 1984-07-26
IE840114L (en) 1984-07-20
JPS59137479A (en) 1984-08-07
EP0116854A3 (en) 1984-12-05
DE3474549D1 (en) 1988-11-17
KR840007230A (en) 1984-12-06
IL70685A0 (en) 1984-04-30
EP0116854B1 (en) 1988-10-12
EP0116854A2 (en) 1984-08-29
NZ206831A (en) 1987-04-30
IL70685A (en) 1988-09-30
DK24084D0 (en) 1984-01-19
IE56572B1 (en) 1991-09-11
ZA84292B (en) 1984-09-26
ATE37879T1 (en) 1988-10-15
PH19214A (en) 1986-02-04
CA1251454A (en) 1989-03-21

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