IE47489B1 - 4-desacetoxy-4a-hydroxyindole-dihydroindoles,pharmaceutical formulations containing them and their use as antimitotic agents - Google Patents

4-desacetoxy-4a-hydroxyindole-dihydroindoles,pharmaceutical formulations containing them and their use as antimitotic agents

Info

Publication number
IE47489B1
IE47489B1 IE2189/78A IE218978A IE47489B1 IE 47489 B1 IE47489 B1 IE 47489B1 IE 2189/78 A IE2189/78 A IE 2189/78A IE 218978 A IE218978 A IE 218978A IE 47489 B1 IE47489 B1 IE 47489B1
Authority
IE
Ireland
Prior art keywords
desacetoxy
formula
indole
dihydroindole
process according
Prior art date
Application number
IE2189/78A
Other languages
English (en)
Other versions
IE782189L (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/848,837 external-priority patent/US4122082A/en
Priority claimed from US05/890,422 external-priority patent/US4195022A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Priority to IE401/83A priority Critical patent/IE47490B1/en
Publication of IE782189L publication Critical patent/IE782189L/xx
Publication of IE47489B1 publication Critical patent/IE47489B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IE2189/78A 1977-11-07 1978-11-06 4-desacetoxy-4a-hydroxyindole-dihydroindoles,pharmaceutical formulations containing them and their use as antimitotic agents IE47489B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IE401/83A IE47490B1 (en) 1977-11-07 1978-11-06 4-desacetoxy-oxo-indole-dihydroindole intermediates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/848,837 US4122082A (en) 1977-11-07 1977-11-07 4-Desacetoxy-4-oxovinblastine
US05/890,422 US4195022A (en) 1978-03-27 1978-03-27 4-Desacetoxy-4α-hydroxyvinblastine and related compounds

Publications (2)

Publication Number Publication Date
IE782189L IE782189L (en) 1979-05-07
IE47489B1 true IE47489B1 (en) 1984-04-04

Family

ID=27126805

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2189/78A IE47489B1 (en) 1977-11-07 1978-11-06 4-desacetoxy-4a-hydroxyindole-dihydroindoles,pharmaceutical formulations containing them and their use as antimitotic agents

Country Status (11)

Country Link
JP (1) JPS5473796A (da)
AR (1) AR227620A1 (da)
CH (1) CH638814A5 (da)
DK (1) DK147302C (da)
FR (1) FR2407935A1 (da)
GB (2) GB2012260B (da)
HU (1) HU184623B (da)
IE (1) IE47489B1 (da)
IL (1) IL55865A (da)
IT (1) IT1100920B (da)
LU (1) LU80474A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU185691B (en) * 1982-02-09 1985-03-28 Richter Gedeon Vegyeszet Process for preparing a new analgetic pharmaceutical composition
FR2894966B1 (fr) * 2005-12-20 2008-03-14 Pierre Fabre Medicament Sa Nouvelle forme cristalline de la vinflunine
USD973040S1 (en) * 2020-11-06 2022-12-20 Lite-On Electronics (Guangzhou) Limited Antenna monitoring tool box

Also Published As

Publication number Publication date
AR227620A1 (es) 1982-11-30
DK147302B (da) 1984-06-12
IL55865A (en) 1982-11-30
IT7829435A0 (it) 1978-11-03
DK494178A (da) 1979-05-08
HU184623B (en) 1984-09-28
GB2089806A (en) 1982-06-30
GB2012260A (en) 1979-07-25
FR2407935A1 (fr) 1979-06-01
IL55865A0 (en) 1979-01-31
GB2012260B (en) 1982-11-03
CH638814A5 (fr) 1983-10-14
IE782189L (en) 1979-05-07
IT1100920B (it) 1985-09-28
GB2089806B (en) 1982-11-24
JPS5473796A (en) 1979-06-13
LU80474A1 (fr) 1979-03-19
DK147302C (da) 1985-01-02
FR2407935B1 (da) 1981-06-26

Similar Documents

Publication Publication Date Title
EP0005051B1 (en) 4-desacetyl vlb c-3 carboxhydrazides, their preparation and formulations containing them
EP0001920B1 (en) Vincaleukoblastine derivatives, a process for their preparation, pharmaceutical formulations containing them and the derivatives for use as antimitotic agents
EP1200444B1 (en) Novel xanthone compounds, their preparation and use as medicament
IE47489B1 (en) 4-desacetoxy-4a-hydroxyindole-dihydroindoles,pharmaceutical formulations containing them and their use as antimitotic agents
IE42385B1 (en) Novel amide derivatives of dimeric alkaloids
US4096148A (en) Oxazolidinedione derivatives of Vinca alkaloids
US4143041A (en) 4'-Deoxyvincristine and related compounds
US4195022A (en) 4-Desacetoxy-4α-hydroxyvinblastine and related compounds
US3954773A (en) 4-Desacetoxyvinblastine
US3887565A (en) Vincadioline
US4189432A (en) N-formyl and N-desmethyl leurosine derivatives
US4122081A (en) 5'-Hydroxyleurosine and related compounds
IE46692B1 (en) 4'-deoxy-vinca alkaloids
US4160767A (en) Vinca alkaloid intermediates
USRE30560E (en) Oxazolidinedione derivatives of Vinca alkaloids
US4110330A (en) 5'-Acetonylvincristine and related compounds
US4175080A (en) Process of producing 5'-hydroxyleurosine and related compounds
US4357334A (en) Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
US4320058A (en) 20'-Hydroxyvinblastine and related compounds
KR810000494B1 (ko) 빈카 알카로이드의 옥사졸리딘 디온 유도체의 제조방법
IE47490B1 (en) 4-desacetoxy-oxo-indole-dihydroindole intermediates
CA1088527A (en) 4'-deoxyvincristine and related compounds
KR810001489B1 (ko) 빈카 알카로이드의 옥사졸리딘 디온 유도체의 제조방법
KR810001982B1 (ko) 4-데스아세틸인돌-디하이드로인돌 이량체의 제조방법
KR810001983B1 (ko) 1-포르밀 인돌-디하이드로인돌 이량체의 제조방법