IE44858L - HYPOLIPIDEMIC p-AMINOBENZOIC ACIDS - Google Patents

HYPOLIPIDEMIC p-AMINOBENZOIC ACIDS

Info

Publication number
IE44858L
IE44858L IE770104A IE10477A IE44858L IE 44858 L IE44858 L IE 44858L IE 770104 A IE770104 A IE 770104A IE 10477 A IE10477 A IE 10477A IE 44858 L IE44858 L IE 44858L
Authority
IE
Ireland
Prior art keywords
ylmethylamino
benzodioxol
formula
hypolipidemic
aminobenzoic
Prior art date
Application number
IE770104A
Other versions
IE44858B1 (en
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of IE44858L publication Critical patent/IE44858L/en
Publication of IE44858B1 publication Critical patent/IE44858B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Abstract

Schiff's bases of the formula I <IMAGE> in which R is hydrogen or lower alkyl are obtained by reacting piperonal with p-aminobenzoic acid or with a p-aminobenzoic ester. 4-(1,3-Benzodioxol-5-ylmethylamino)benzoic acid and 4-(1,3-benzodioxol-5-ylmethylamino)benzoic esters of the formula II <IMAGE> in which R is hydrogen or lower alkyl are obtained by reducing Schiff's bases of the formula I. The compound 4-(1,3-benzodioxol-5-ylmethylamino)benzoic acid which can be prepared according to the invention can be used, for example, for the reduction of the lipid level in the plasma of animals. [GB1521458A]
IE104/77A 1976-01-19 1977-01-19 Hypolipidemic p-aminobenzoic acids IE44858B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65009076A 1976-01-19 1976-01-19

Publications (2)

Publication Number Publication Date
IE44858L true IE44858L (en) 1977-07-19
IE44858B1 IE44858B1 (en) 1982-04-21

Family

ID=24607411

Family Applications (1)

Application Number Title Priority Date Filing Date
IE104/77A IE44858B1 (en) 1976-01-19 1977-01-19 Hypolipidemic p-aminobenzoic acids

Country Status (14)

Country Link
JP (1) JPS5289660A (en)
AT (1) AT347923B (en)
AU (1) AU500881B2 (en)
BE (1) BE850516A (en)
CA (1) CA1072969A (en)
CH (1) CH628340A5 (en)
DE (1) DE2702058C2 (en)
DK (1) DK153471C (en)
FR (1) FR2338040A1 (en)
GB (2) GB1521458A (en)
IE (1) IE44858B1 (en)
NL (1) NL7700480A (en)
NO (1) NO145839C (en)
SE (1) SE435175B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0424904Y2 (en) * 1987-09-18 1992-06-12

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE716668C (en) * 1938-02-15 1942-01-27 Dr Aladar Skita Process for the preparation of derivatives of substituted aminobenzoic acids
FR2080069A5 (en) * 1970-02-23 1971-11-12 Commissariat Energie Atomique
US3868416A (en) * 1973-10-01 1975-02-25 American Cyanamid Co Hypolipidemic 4-(monoalkylamino)benzoic acid derivatives

Also Published As

Publication number Publication date
IE44858B1 (en) 1982-04-21
NL7700480A (en) 1977-07-21
NO145839C (en) 1982-06-09
SE435175B (en) 1984-09-10
GB1521459A (en) 1978-08-16
NO145839B (en) 1982-03-01
DK153471B (en) 1988-07-18
FR2338040A1 (en) 1977-08-12
AT347923B (en) 1979-01-25
DE2702058A1 (en) 1977-07-28
ATA31277A (en) 1978-06-15
CA1072969A (en) 1980-03-04
FR2338040B1 (en) 1980-04-30
AU2114077A (en) 1978-07-13
NO770151L (en) 1977-07-20
SE7700490L (en) 1977-07-20
DE2702058C2 (en) 1985-09-19
DK153471C (en) 1988-11-21
CH628340A5 (en) 1982-02-26
JPS5289660A (en) 1977-07-27
DK8177A (en) 1977-07-20
JPS6233230B2 (en) 1987-07-20
AU500881B2 (en) 1979-06-07
GB1521458A (en) 1978-08-16
BE850516A (en) 1977-07-19

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Legal Events

Date Code Title Description
MM4A Patent lapsed