IE40875B1 - A process for preparing 7-acylamino-7-alkoxycephalosporinsor 6-acylamino-6-alkoxypenicillins - Google Patents
A process for preparing 7-acylamino-7-alkoxycephalosporinsor 6-acylamino-6-alkoxypenicillinsInfo
- Publication number
- IE40875B1 IE40875B1 IE641/75A IE64175A IE40875B1 IE 40875 B1 IE40875 B1 IE 40875B1 IE 641/75 A IE641/75 A IE 641/75A IE 64175 A IE64175 A IE 64175A IE 40875 B1 IE40875 B1 IE 40875B1
- Authority
- IE
- Ireland
- Prior art keywords
- alpha
- halogeno
- beta
- acylamino
- reacting
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 229930186147 Cephalosporin Natural products 0.000 abstract 2
- 229930182555 Penicillin Natural products 0.000 abstract 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 abstract 2
- -1 alkali metal alkoxide Chemical class 0.000 abstract 2
- 239000002585 base Substances 0.000 abstract 2
- 229940124587 cephalosporin Drugs 0.000 abstract 2
- 150000001780 cephalosporins Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000002140 halogenating effect Effects 0.000 abstract 2
- 229940049954 penicillin Drugs 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000036571 hydration Effects 0.000 abstract 1
- 238000006703 hydration reaction Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3239274A JPS5512034B2 (https=) | 1974-03-22 | 1974-03-22 | |
| JP3239174A JPS5512036B2 (https=) | 1974-03-22 | 1974-03-22 | |
| JP3973074A JPS5519235B2 (https=) | 1974-04-08 | 1974-04-08 | |
| JP4153074A JPS5720957B2 (https=) | 1974-04-13 | 1974-04-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40875L IE40875L (en) | 1975-09-22 |
| IE40875B1 true IE40875B1 (en) | 1979-08-29 |
Family
ID=27459600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE641/75A IE40875B1 (en) | 1974-03-22 | 1975-03-21 | A process for preparing 7-acylamino-7-alkoxycephalosporinsor 6-acylamino-6-alkoxypenicillins |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3960845A (https=) |
| CA (1) | CA1067486A (https=) |
| CH (1) | CH612973A5 (https=) |
| DE (1) | DE2512670C2 (https=) |
| DK (1) | DK157138C (https=) |
| FR (1) | FR2274299A1 (https=) |
| GB (1) | GB1463468A (https=) |
| HU (1) | HU174378B (https=) |
| IE (1) | IE40875B1 (https=) |
| NL (1) | NL167436C (https=) |
| SE (3) | SE426828B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4059578A (en) * | 1974-09-09 | 1977-11-22 | Smithkline Corporation | 7-Substituted mercaptoacetamido cephamycins |
| JPS5941999B2 (ja) | 1975-07-24 | 1984-10-11 | 武田薬品工業株式会社 | セフエムまたはベナム化合物の製造法 |
| US4162251A (en) * | 1976-04-05 | 1979-07-24 | Sankyo Company Limited | Process for the preparation of β-lactam compounds |
| GB1578748A (en) * | 1976-06-26 | 1980-11-12 | Beecham Group Ltd | 6-keterinimo-penicillins and their use as intermediates |
| GB1583543A (en) * | 1976-06-26 | 1981-01-28 | Beecham Group Ltd | 7-ketenimino-cephalosporins and their use as intermediates |
| US4185014A (en) | 1976-06-26 | 1980-01-22 | Beecham Group Limited | Kentenimine intermediates for 6α-methoxy-α-carboxy penicillins |
| US4121041A (en) * | 1977-02-04 | 1978-10-17 | Merck & Co., Inc. | 7-(Amidinothio)acetamido-7-methoxy cephalosporins |
| JPS6052713B2 (ja) * | 1978-04-11 | 1985-11-20 | 三共株式会社 | ７−メトキシセフアロスポリン化合物、その製法及びその化合物を主成分とする抗菌剤 |
| JPS57169488A (en) * | 1981-04-13 | 1982-10-19 | Meiji Seika Kaisha Ltd | Cephem compound and its preparation |
| EP0095320A1 (en) * | 1982-05-21 | 1983-11-30 | Beecham Group Plc | A process for the preparation of beta-lactam compounds |
| DE3373475D1 (en) * | 1982-12-14 | 1987-10-15 | Beecham Group Plc | Process for the preparation of beta-lactam compounds |
| CN102153567B (zh) * | 2010-05-28 | 2013-08-14 | 重庆天地药业有限责任公司 | 一种制备头孢西丁酸的方法 |
| CN102268021A (zh) * | 2011-06-16 | 2011-12-07 | 哈药集团制药总厂 | 一种头孢米诺钠的制备方法 |
| CN103709179B (zh) * | 2013-12-17 | 2016-03-30 | 福建省福抗药业股份有限公司 | 一种头孢美唑钠的合成及提纯方法 |
| CN105017287B (zh) * | 2015-08-18 | 2018-01-12 | 齐鲁安替（临邑）制药有限公司 | 一种头霉素中间体的制备方法 |
| CN108299471B (zh) * | 2017-01-12 | 2021-03-12 | 重庆常捷医药有限公司 | 一种头孢美唑中间体的改进制备工艺 |
| CN106995453B (zh) * | 2017-04-01 | 2019-05-03 | 齐鲁安替制药有限公司 | 头孢菌素中间体7α-甲氧基头孢噻吩的结晶及其制备方法 |
| CN110590812A (zh) * | 2019-10-29 | 2019-12-20 | 重庆天地药业有限责任公司 | 一种头孢米诺钠的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3843641A (en) * | 1971-11-29 | 1974-10-22 | Merck & Co Inc | Process for preparing penicillin and cephalosporin compounds |
| US3778432A (en) * | 1971-12-13 | 1973-12-11 | Merck & Co Inc | Isocyanates and carbamates of penicillins and 3-cephem-4-carboxylic acids |
-
1975
- 1975-03-04 US US05/555,195 patent/US3960845A/en not_active Expired - Lifetime
- 1975-03-20 SE SE7503200A patent/SE426828B/xx not_active IP Right Cessation
- 1975-03-21 IE IE641/75A patent/IE40875B1/xx unknown
- 1975-03-21 GB GB1195875A patent/GB1463468A/en not_active Expired
- 1975-03-21 DK DK119875A patent/DK157138C/da not_active IP Right Cessation
- 1975-03-21 CA CA222,728A patent/CA1067486A/en not_active Expired
- 1975-03-21 CH CH369275A patent/CH612973A5/xx not_active IP Right Cessation
- 1975-03-21 DE DE2512670A patent/DE2512670C2/de not_active Expired
- 1975-03-21 HU HU75SA2763A patent/HU174378B/hu unknown
- 1975-03-24 NL NL7503513.A patent/NL167436C/xx not_active IP Right Cessation
- 1975-03-24 FR FR7509087A patent/FR2274299A1/fr active Granted
-
1978
- 1978-11-10 SE SE7811635A patent/SE434949B/sv not_active IP Right Cessation
-
1983
- 1983-07-22 SE SE8304108A patent/SE453666B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1067486A (en) | 1979-12-04 |
| SE426828B (sv) | 1983-02-14 |
| SE453666B (sv) | 1988-02-22 |
| FR2274299B1 (https=) | 1978-08-18 |
| SE434949B (sv) | 1984-08-27 |
| US3960845A (en) | 1976-06-01 |
| DE2512670C2 (de) | 1983-02-03 |
| NL167436B (nl) | 1981-07-16 |
| DK119875A (https=) | 1975-09-23 |
| CH612973A5 (https=) | 1979-08-31 |
| SE7503200L (https=) | 1975-09-23 |
| SE7811635L (sv) | 1978-11-10 |
| NL7503513A (nl) | 1975-09-24 |
| SE8304108D0 (sv) | 1983-07-22 |
| DE2512670A1 (de) | 1975-09-25 |
| DK157138B (da) | 1989-11-13 |
| SE8304108L (sv) | 1983-07-22 |
| IE40875L (en) | 1975-09-22 |
| HU174378B (hu) | 1979-12-28 |
| FR2274299A1 (fr) | 1976-01-09 |
| NL167436C (nl) | 1981-12-16 |
| DK157138C (da) | 1990-04-16 |
| GB1463468A (en) | 1977-02-02 |
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