IE38987B1 - 1,2,4-triazole-3-carboxamides as antiviral agents - Google Patents
1,2,4-triazole-3-carboxamides as antiviral agentsInfo
- Publication number
- IE38987B1 IE38987B1 IE00506/74A IE50674A IE38987B1 IE 38987 B1 IE38987 B1 IE 38987B1 IE 00506/74 A IE00506/74 A IE 00506/74A IE 50674 A IE50674 A IE 50674A IE 38987 B1 IE38987 B1 IE 38987B1
- Authority
- IE
- Ireland
- Prior art keywords
- triazole
- carboxamide
- yield
- prepared
- march
- Prior art date
Links
- ZEWJFUNFEABPGL-UHFFFAOYSA-N 1,2,4-triazole-3-carboxamide Chemical class NC(=O)C=1N=CNN=1 ZEWJFUNFEABPGL-UHFFFAOYSA-N 0.000 title abstract 4
- 239000003443 antiviral agent Substances 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- GUQHFZFTGHNVDG-UHFFFAOYSA-N 1h-1,2,4-triazole-5-carbonitrile Chemical compound N#CC1=NC=NN1 GUQHFZFTGHNVDG-UHFFFAOYSA-N 0.000 abstract 1
- VYJPYFZLFQUVFZ-UHFFFAOYSA-N 1h-1,2,4-triazole-5-carbothioamide Chemical compound NC(=S)C1=NC=NN1 VYJPYFZLFQUVFZ-UHFFFAOYSA-N 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 102100036286 Purine nucleoside phosphorylase Human genes 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- QMPFMODFBNEYJH-UHFFFAOYSA-N methyl 1h-1,2,4-triazole-5-carboxylate Chemical compound COC(=O)C1=NC=NN1 QMPFMODFBNEYJH-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- RPMBQFASZSFPQD-UHFFFAOYSA-N n'-amino-1-cyanomethanimidamide Chemical compound NNC(=N)C#N RPMBQFASZSFPQD-UHFFFAOYSA-N 0.000 abstract 1
- 108010009099 nucleoside phosphorylase Proteins 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- CGHGUMDRADFZLN-UHFFFAOYSA-M sodium 1H-1,2,4-triazole-5-carbonylazanide Chemical compound [Na+].N1N=C(N=C1)C(=O)[NH-] CGHGUMDRADFZLN-UHFFFAOYSA-M 0.000 abstract 1
- GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US340332A US3927216A (en) | 1971-06-01 | 1973-03-12 | 1,2,4-Triazol E-3-carboxamides for inhibiting virus infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38987L IE38987L (en) | 1974-09-12 |
| IE38987B1 true IE38987B1 (en) | 1978-07-05 |
Family
ID=23332899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE00506/74A IE38987B1 (en) | 1973-03-12 | 1974-03-11 | 1,2,4-triazole-3-carboxamides as antiviral agents |
Country Status (15)
| Country | Link |
|---|---|
| JP (2) | JPS5836960B2 (enExample) |
| AR (1) | AR205339A1 (enExample) |
| BE (2) | BE812191A (enExample) |
| CH (1) | CH602785A5 (enExample) |
| DE (1) | DE2411823A1 (enExample) |
| ES (1) | ES424201A1 (enExample) |
| FR (2) | FR2221138B1 (enExample) |
| GB (1) | GB1427304A (enExample) |
| IE (1) | IE38987B1 (enExample) |
| IL (2) | IL44394A0 (enExample) |
| LU (1) | LU69626A1 (enExample) |
| NL (1) | NL7403289A (enExample) |
| NO (1) | NO138376C (enExample) |
| PH (1) | PH12043A (enExample) |
| ZA (1) | ZA741610B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2940654A1 (de) * | 1979-10-06 | 1981-04-16 | Bayer Ag, 5090 Leverkusen | Dimeres keten der 1,2,,-triazol-3-carbonsaeure |
| EP0034481B1 (en) * | 1980-02-14 | 1984-05-30 | Grigg, Ronald Ernest | 2-methyl-5-thiazole-methylamine and carboxamide derivatives |
| IL62695A (en) * | 1980-04-23 | 1984-03-30 | Wellcome Found | Synthesis of 4-substituted-1beta-d-ribofuranosyl-1h-imidazo(4,5-c)pyridines |
| JPS57146593A (en) * | 1981-03-09 | 1982-09-10 | Ajinomoto Co Inc | Preparation of ribofuranosyltriazole derivative |
| BE902199A (fr) * | 1984-10-29 | 1985-07-31 | Vira Tek Inc | Procede de traitement medical de maladies virales utilisant le 1-beta-d-ribofurannosyl-1, 2,4-triazole-3-carboxamide. |
| JPS62165096A (ja) * | 1986-01-14 | 1987-07-21 | Hitachi Ltd | 給油装置 |
| WO2009028575A1 (ja) | 2007-08-27 | 2009-03-05 | National University Corporation Nagoya University | 血液凝固第vii因子プロモーターの活性化剤及びその利用 |
| EP2201953A4 (en) | 2007-08-27 | 2011-08-03 | Univ Nagoya Nat Univ Corp | USE OF RIBAVIRIN IN BLOOD CLEANING DISORDERS |
-
1974
- 1974-01-01 AR AR252737A patent/AR205339A1/es active
- 1974-03-11 FR FR7408233A patent/FR2221138B1/fr not_active Expired
- 1974-03-11 NO NO740841A patent/NO138376C/no unknown
- 1974-03-11 IL IL44394A patent/IL44394A0/xx unknown
- 1974-03-11 GB GB1078374A patent/GB1427304A/en not_active Expired
- 1974-03-11 IE IE00506/74A patent/IE38987B1/xx unknown
- 1974-03-12 ES ES424201A patent/ES424201A1/es not_active Expired
- 1974-03-12 LU LU69626A patent/LU69626A1/xx unknown
- 1974-03-12 DE DE2411823A patent/DE2411823A1/de active Pending
- 1974-03-12 PH PH15614A patent/PH12043A/en unknown
- 1974-03-12 ZA ZA00741610A patent/ZA741610B/xx unknown
- 1974-03-12 CH CH343674A patent/CH602785A5/xx not_active IP Right Cessation
- 1974-03-12 BE BE141915A patent/BE812191A/xx unknown
- 1974-03-12 NL NL7403289A patent/NL7403289A/xx not_active Application Discontinuation
- 1974-03-12 JP JP49028432A patent/JPS5836960B2/ja not_active Expired
-
1975
- 1975-12-03 FR FR7537057A patent/FR2289520A1/fr active Granted
-
1977
- 1977-08-29 IL IL52848A patent/IL52848A0/xx unknown
-
1983
- 1983-04-21 JP JP58069292A patent/JPS5915886B2/ja not_active Expired
-
1985
- 1985-11-19 BE BE0/215891A patent/BE903675Q/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO138376C (no) | 1978-08-23 |
| ZA741610B (en) | 1975-02-26 |
| BE903675Q (fr) | 1986-05-20 |
| JPS5915886B2 (ja) | 1984-04-12 |
| IL44394A0 (en) | 1974-06-30 |
| LU69626A1 (enExample) | 1974-08-06 |
| GB1427304A (en) | 1976-03-10 |
| IE38987L (en) | 1974-09-12 |
| BE812191A (fr) | 1974-07-01 |
| FR2221138A1 (enExample) | 1974-10-11 |
| PH12043A (en) | 1978-10-18 |
| AR205339A1 (es) | 1976-04-30 |
| AU6670874A (en) | 1975-09-18 |
| JPS58219115A (ja) | 1983-12-20 |
| FR2289520A1 (fr) | 1976-05-28 |
| JPS5029720A (enExample) | 1975-03-25 |
| FR2221138B1 (enExample) | 1978-07-28 |
| NL7403289A (enExample) | 1974-09-16 |
| NO138376B (no) | 1978-05-16 |
| JPS5836960B2 (ja) | 1983-08-12 |
| IL52848A0 (en) | 1977-10-31 |
| DE2411823A1 (de) | 1974-09-26 |
| CH602785A5 (enExample) | 1978-08-15 |
| NO740841L (no) | 1974-09-13 |
| ES424201A1 (es) | 1976-05-01 |
| FR2289520B1 (enExample) | 1978-05-12 |
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