IE38987L - 1,2,4-triazole-3-carboxyamides as antiviral agents - Google Patents
1,2,4-triazole-3-carboxyamides as antiviral agentsInfo
- Publication number
- IE38987L IE38987L IE740506A IE50674A IE38987L IE 38987 L IE38987 L IE 38987L IE 740506 A IE740506 A IE 740506A IE 50674 A IE50674 A IE 50674A IE 38987 L IE38987 L IE 38987L
- Authority
- IE
- Ireland
- Prior art keywords
- triazole
- carboxamide
- yield
- prepared
- march
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
1427304 1,2,4 - Triazole - 3 - carboxamide and derivatives thereof ICN PHARMACEUTICALS Inc 11 March 1974 [12 March 1973] 10783/74 Heading C2C [Also in Division A5] 1 - # - D - Ribofuranosyl - 1,2,4 - triazole - 3- carboxamide is prepared by heating methyl 1,2,4 - triazole carboxylate with aqueous ammonia to yield 1,2,4 - triazole - 3 - carboxamide which is then reacted with the enzyme nucleoside phosphorylase to yield the desired product. The semihydrate of 1,2,4-triazole-3-carboxamide sodium salt is prepared by reacting the 1,2,4- triazole-3-carboxamide with sodium hydroxide. 1,2,4 - Triazole - 3 - thiocarboxamide is prepared by treating a mixture of triethyl orthoformate and 1-cyanoformimidic acid hydrazide with a solution of dioxane saturated with anhydrous hydrogen chloride to yield 3-cyano- 1,2,4-triazole which is then reacted with ethanol, triethylamine and hydrogen sulphide gas to yield the desired product.
[GB1427304A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US340332A US3927216A (en) | 1971-06-01 | 1973-03-12 | 1,2,4-Triazol E-3-carboxamides for inhibiting virus infections |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38987L true IE38987L (en) | 1974-09-12 |
| IE38987B1 IE38987B1 (en) | 1978-07-05 |
Family
ID=23332899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE00506/74A IE38987B1 (en) | 1973-03-12 | 1974-03-11 | 1,2,4-triazole-3-carboxamides as antiviral agents |
Country Status (15)
| Country | Link |
|---|---|
| JP (2) | JPS5836960B2 (en) |
| AR (1) | AR205339A1 (en) |
| BE (2) | BE812191A (en) |
| CH (1) | CH602785A5 (en) |
| DE (1) | DE2411823A1 (en) |
| ES (1) | ES424201A1 (en) |
| FR (2) | FR2221138B1 (en) |
| GB (1) | GB1427304A (en) |
| IE (1) | IE38987B1 (en) |
| IL (2) | IL44394A0 (en) |
| LU (1) | LU69626A1 (en) |
| NL (1) | NL7403289A (en) |
| NO (1) | NO138376C (en) |
| PH (1) | PH12043A (en) |
| ZA (1) | ZA741610B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2940654A1 (en) * | 1979-10-06 | 1981-04-16 | Bayer Ag, 5090 Leverkusen | DIMERES KETEN OF 1,2 ,, - TRIAZOL-3-CARBONIC ACID |
| ATE7694T1 (en) * | 1980-02-14 | 1984-06-15 | Grigg, Ronald Ernest | DERIVATIVES OF 2-METHYL-5-THIAZOLMETHYLAMINE AND CARBOXAMIDE. |
| CA1162155A (en) * | 1980-04-23 | 1984-02-14 | Thomas A. Krenitsky | Synthesis of deazapurine nucleosides |
| JPS57146593A (en) * | 1981-03-09 | 1982-09-10 | Ajinomoto Co Inc | Preparation of ribofuranosyltriazole derivative |
| BE902199A (en) * | 1984-10-29 | 1985-07-31 | Vira Tek Inc | METHOD OF MEDICAL TREATMENT OF VIRAL DISEASES USING 1-BETA-D-RIBOFURANNOSYL-1, 2,4-TRIAZOLE-3-CARBOXAMIDE. |
| JPS62165096A (en) * | 1986-01-14 | 1987-07-21 | Hitachi Ltd | Oil supplying device |
| JPWO2009028573A1 (en) | 2007-08-27 | 2010-12-09 | 国立大学法人名古屋大学 | Use of ribavirin in blood coagulation disorders |
| WO2009028575A1 (en) | 2007-08-27 | 2009-03-05 | National University Corporation Nagoya University | Activator for blood coagulation factor vii promoter and utilization of the same |
-
1974
- 1974-01-01 AR AR252737A patent/AR205339A1/en active
- 1974-03-11 NO NO740841A patent/NO138376C/en unknown
- 1974-03-11 IE IE00506/74A patent/IE38987B1/en unknown
- 1974-03-11 GB GB1078374A patent/GB1427304A/en not_active Expired
- 1974-03-11 FR FR7408233A patent/FR2221138B1/fr not_active Expired
- 1974-03-11 IL IL44394A patent/IL44394A0/en unknown
- 1974-03-12 ES ES424201A patent/ES424201A1/en not_active Expired
- 1974-03-12 LU LU69626A patent/LU69626A1/xx unknown
- 1974-03-12 PH PH15614A patent/PH12043A/en unknown
- 1974-03-12 DE DE2411823A patent/DE2411823A1/en active Pending
- 1974-03-12 NL NL7403289A patent/NL7403289A/xx not_active Application Discontinuation
- 1974-03-12 BE BE141915A patent/BE812191A/en unknown
- 1974-03-12 CH CH343674A patent/CH602785A5/xx not_active IP Right Cessation
- 1974-03-12 JP JP49028432A patent/JPS5836960B2/en not_active Expired
- 1974-03-12 ZA ZA00741610A patent/ZA741610B/en unknown
-
1975
- 1975-12-03 FR FR7537057A patent/FR2289520A1/en active Granted
-
1977
- 1977-08-29 IL IL52848A patent/IL52848A0/en unknown
-
1983
- 1983-04-21 JP JP58069292A patent/JPS5915886B2/en not_active Expired
-
1985
- 1985-11-19 BE BE0/215891A patent/BE903675Q/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58219115A (en) | 1983-12-20 |
| JPS5915886B2 (en) | 1984-04-12 |
| AR205339A1 (en) | 1976-04-30 |
| ZA741610B (en) | 1975-02-26 |
| FR2289520B1 (en) | 1978-05-12 |
| NO138376C (en) | 1978-08-23 |
| FR2289520A1 (en) | 1976-05-28 |
| JPS5029720A (en) | 1975-03-25 |
| IL52848A0 (en) | 1977-10-31 |
| DE2411823A1 (en) | 1974-09-26 |
| NL7403289A (en) | 1974-09-16 |
| IE38987B1 (en) | 1978-07-05 |
| BE812191A (en) | 1974-07-01 |
| IL44394A0 (en) | 1974-06-30 |
| NO138376B (en) | 1978-05-16 |
| NO740841L (en) | 1974-09-13 |
| CH602785A5 (en) | 1978-08-15 |
| FR2221138B1 (en) | 1978-07-28 |
| BE903675Q (en) | 1986-05-20 |
| FR2221138A1 (en) | 1974-10-11 |
| PH12043A (en) | 1978-10-18 |
| JPS5836960B2 (en) | 1983-08-12 |
| AU6670874A (en) | 1975-09-18 |
| LU69626A1 (en) | 1974-08-06 |
| ES424201A1 (en) | 1976-05-01 |
| GB1427304A (en) | 1976-03-10 |
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