ES424201A1 - 1,2,4-triazole-3-carboxamides as antiviral agents - Google Patents

1,2,4-triazole-3-carboxamides as antiviral agents

Info

Publication number
ES424201A1
ES424201A1 ES424201A ES424201A ES424201A1 ES 424201 A1 ES424201 A1 ES 424201A1 ES 424201 A ES424201 A ES 424201A ES 424201 A ES424201 A ES 424201A ES 424201 A1 ES424201 A1 ES 424201A1
Authority
ES
Spain
Prior art keywords
carboxamides
antiviral agents
triazole
triazol
ribose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES424201A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valeant Pharmaceuticals International Inc USA
Original Assignee
ICN Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US340332A external-priority patent/US3927216A/en
Application filed by ICN Pharmaceuticals Inc filed Critical ICN Pharmaceuticals Inc
Publication of ES424201A1 publication Critical patent/ES424201A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Procedure for obtaining 1,2,4-triazol-3-carboxamides as antiviral agents, characterized in that 1,2,4-triazol-3-carboxamide is reacted with the nucleoside phosphorylase enzyme in the presence of ribose-1- phosphate, at a pH of from about 5 to about 9 and at a temperature from about 0 to about 50ºC. (Machine-translation by Google Translate, not legally binding)
ES424201A 1973-03-12 1974-03-12 1,2,4-triazole-3-carboxamides as antiviral agents Expired ES424201A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US340332A US3927216A (en) 1971-06-01 1973-03-12 1,2,4-Triazol E-3-carboxamides for inhibiting virus infections

Publications (1)

Publication Number Publication Date
ES424201A1 true ES424201A1 (en) 1976-05-01

Family

ID=23332899

Family Applications (1)

Application Number Title Priority Date Filing Date
ES424201A Expired ES424201A1 (en) 1973-03-12 1974-03-12 1,2,4-triazole-3-carboxamides as antiviral agents

Country Status (15)

Country Link
JP (2) JPS5836960B2 (en)
AR (1) AR205339A1 (en)
BE (2) BE812191A (en)
CH (1) CH602785A5 (en)
DE (1) DE2411823A1 (en)
ES (1) ES424201A1 (en)
FR (2) FR2221138B1 (en)
GB (1) GB1427304A (en)
IE (1) IE38987B1 (en)
IL (2) IL44394A0 (en)
LU (1) LU69626A1 (en)
NL (1) NL7403289A (en)
NO (1) NO138376C (en)
PH (1) PH12043A (en)
ZA (1) ZA741610B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2940654A1 (en) * 1979-10-06 1981-04-16 Bayer Ag, 5090 Leverkusen DIMERES KETEN OF 1,2 ,, - TRIAZOL-3-CARBONIC ACID
EP0034481B1 (en) * 1980-02-14 1984-05-30 Grigg, Ronald Ernest 2-methyl-5-thiazole-methylamine and carboxamide derivatives
JPS56164793A (en) * 1980-04-23 1981-12-17 Wellcome Found Pyridine derivative
JPS57146593A (en) * 1981-03-09 1982-09-10 Ajinomoto Co Inc Preparation of ribofuranosyltriazole derivative
BE902199A (en) * 1984-10-29 1985-07-31 Vira Tek Inc METHOD OF MEDICAL TREATMENT OF VIRAL DISEASES USING 1-BETA-D-RIBOFURANNOSYL-1, 2,4-TRIAZOLE-3-CARBOXAMIDE.
JPS62165096A (en) * 1986-01-14 1987-07-21 Hitachi Ltd Oil supplying device
JPWO2009028575A1 (en) 2007-08-27 2010-12-02 国立大学法人名古屋大学 Activator of blood coagulation factor VII promoter and use thereof
JPWO2009028573A1 (en) 2007-08-27 2010-12-09 国立大学法人名古屋大学 Use of ribavirin in blood coagulation disorders

Also Published As

Publication number Publication date
BE903675Q (en) 1986-05-20
IE38987L (en) 1974-09-12
DE2411823A1 (en) 1974-09-26
NO138376B (en) 1978-05-16
IL44394A0 (en) 1974-06-30
FR2221138B1 (en) 1978-07-28
FR2289520B1 (en) 1978-05-12
BE812191A (en) 1974-07-01
GB1427304A (en) 1976-03-10
CH602785A5 (en) 1978-08-15
JPS58219115A (en) 1983-12-20
JPS5915886B2 (en) 1984-04-12
LU69626A1 (en) 1974-08-06
FR2289520A1 (en) 1976-05-28
NO138376C (en) 1978-08-23
AR205339A1 (en) 1976-04-30
PH12043A (en) 1978-10-18
AU6670874A (en) 1975-09-18
JPS5029720A (en) 1975-03-25
IL52848A0 (en) 1977-10-31
NL7403289A (en) 1974-09-16
FR2221138A1 (en) 1974-10-11
NO740841L (en) 1974-09-13
JPS5836960B2 (en) 1983-08-12
IE38987B1 (en) 1978-07-05
ZA741610B (en) 1975-02-26

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