IE38886B1 - Heterocyclic compounds - Google Patents
Heterocyclic compoundsInfo
- Publication number
- IE38886B1 IE38886B1 IE00249/74A IE24974A IE38886B1 IE 38886 B1 IE38886 B1 IE 38886B1 IE 00249/74 A IE00249/74 A IE 00249/74A IE 24974 A IE24974 A IE 24974A IE 38886 B1 IE38886 B1 IE 38886B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl group
- hydrogen atom
- group
- compounds
- hydroxy
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004423 acyloxy group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- XOQQVKDBGLYPGH-UHFFFAOYSA-N 2-oxo-1h-quinoline-3-carboxylic acid Chemical compound C1=CC=C2NC(=O)C(C(=O)O)=CC2=C1 XOQQVKDBGLYPGH-UHFFFAOYSA-N 0.000 abstract 1
- ULRPISSMEBPJLN-UHFFFAOYSA-N 2h-tetrazol-5-amine Chemical compound NC1=NN=NN1 ULRPISSMEBPJLN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229960003540 oxyquinoline Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB924973A GB1433774A (en) | 1973-02-26 | 1973-02-26 | Heterocyclic compounds apparatus for conveying articles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE38886L IE38886L (en) | 1974-08-26 |
| IE38886B1 true IE38886B1 (en) | 1978-06-21 |
Family
ID=9868317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE00249/74A IE38886B1 (en) | 1973-02-26 | 1974-02-08 | Heterocyclic compounds |
Country Status (14)
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2324304A2 (fr) * | 1975-09-22 | 1977-04-15 | Roussel Uclaf | Nouveaux derives de l'acide 3-quinoleine carboxylique, leur procede de preparation et leur application comme medicament |
| US4186201A (en) | 1977-02-07 | 1980-01-29 | Riker Laboratories, Inc. | Methods of using 8(tetrazol-5-ylcarbamoyl)isoquinoline compounds |
| US4264604A (en) | 1977-07-01 | 1981-04-28 | Ciba-Geigy Corporation | Quinolonecarboxylic acid derivatives as bactericides |
| US4390541A (en) | 1980-12-19 | 1983-06-28 | Lilly Industries Limited | Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease |
| FR2509728A1 (fr) * | 1981-07-17 | 1983-01-21 | Roussel Uclaf | Nouveaux derives de la quinoleine, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant |
| US4377579A (en) | 1981-12-03 | 1983-03-22 | Minnesota Mining And Manufacturing Company | N-(Tetrazol-5-yl)phenazine-1-carboxamides |
| FR2537140B1 (fr) * | 1982-12-07 | 1986-07-18 | Roussel Uclaf | Nouveaux derives de la 4-hydroxy-3-quinoleine carboxamide, leur sels, procede de preparation, application a titre de medicaments, et compositions les renfermant |
| EP0298134B1 (en) * | 1987-01-20 | 1992-11-11 | Dainippon Pharmaceutical Co., Ltd. | Aromatic heterocyclic carboxylic acid amide derivatives, process for their preparation, and pharmaceutical composition containing same |
| US4959363A (en) * | 1989-06-23 | 1990-09-25 | Sterling Drug Inc. | Quinolonecarboxamide compounds, their preparation and use as antivirals. |
| US6034100A (en) * | 1993-03-10 | 2000-03-07 | Otsuka Pharmaceutical Co., Ltd. | Method for inhibiting cytokine secretion |
| CA2301599C (en) * | 1997-08-25 | 2003-03-25 | Neurogen Corporation | Substituted 4-oxo-napthyridine-3-carboxamides as gaba brain receptor ligands |
| US6143760A (en) | 1997-08-25 | 2000-11-07 | Neurogen Corporation | Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands |
| EP1056724B1 (en) * | 1998-02-26 | 2005-05-25 | Neurogen Corporation | Substituted cycloalkyl-4-oxonicotinic carboxamides; gaba brain receptor ligands |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| JP4532263B2 (ja) * | 2002-05-14 | 2010-08-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 置換されたキノロンカルボン酸、その誘導体、作用の部位、およびその使用 |
| CN100471842C (zh) | 2003-07-24 | 2009-03-25 | 安斯泰来制药有限公司 | 喹诺酮衍生物或其盐 |
| DK2489659T3 (en) * | 2004-06-24 | 2018-02-12 | Vertex Pharma | Modulators of ATP binding cassette conveyors |
| RU2525115C2 (ru) * | 2004-06-24 | 2014-08-10 | Вертекс Фармасьютикалз Инкорпорейтед | Способ модуляции транспортеров атф-связывающей кассеты |
| EP2502913A3 (en) * | 2004-06-24 | 2013-11-27 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US8354427B2 (en) | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| PT3219705T (pt) | 2005-12-28 | 2020-05-20 | Vertex Pharma | Composições farmacêuticas da forma amorfa de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida |
| SMT201700593T1 (it) | 2009-03-20 | 2018-03-08 | Vertex Pharma | Procedimento per preparare modulatori di regolatore di conduttanza transmembrana di fibrosi cistica |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| IL311180A (en) | 2012-02-27 | 2024-04-01 | Vertex Pharma | Pharmaceutical preparations containing a solid dispersion of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide and uses thereof |
| JP6211509B2 (ja) | 2012-03-02 | 2017-10-11 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| JP6211530B2 (ja) | 2012-11-19 | 2017-10-11 | 武田薬品工業株式会社 | 含窒素複素環化合物 |
| ES2702288T3 (es) | 2014-10-07 | 2019-02-28 | Vertex Pharma | Co-cristales de moduladores de regulador de conductancia transmembrana de la fibrosis quística |
| CN105330602B (zh) * | 2015-12-07 | 2018-02-09 | 江南大学 | 一种癸氧喹酯类似物及其应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1383088A (en) * | 1972-07-03 | 1975-02-05 | Allen & Hanburys Ltd | Pharmacologically active quinaldamide derivatives |
-
1973
- 1973-02-26 GB GB924973A patent/GB1433774A/en not_active Expired
-
1974
- 1974-02-08 IE IE00249/74A patent/IE38886B1/xx unknown
- 1974-02-11 ZA ZA740883A patent/ZA74883B/xx unknown
- 1974-02-14 SE SE7401984A patent/SE7401984L/xx unknown
- 1974-02-14 AU AU65592/74A patent/AU474797B2/en not_active Expired
- 1974-02-18 CH CH224374A patent/CH602707A5/xx not_active IP Right Cessation
- 1974-02-18 DE DE19742407744 patent/DE2407744A1/de active Pending
- 1974-02-19 BE BE141102A patent/BE811246A/xx unknown
- 1974-02-22 LU LU69479A patent/LU69479A1/xx unknown
- 1974-02-25 JP JP49022232A patent/JPS5029574A/ja active Pending
- 1974-02-25 FR FR7406327A patent/FR2218896B1/fr not_active Expired
- 1974-02-25 AT AT149974A patent/AT329562B/de not_active IP Right Cessation
- 1974-02-26 NL NL7402613A patent/NL7402613A/xx not_active Application Discontinuation
- 1974-02-26 CA CA193,476A patent/CA1025856A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH602707A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-07-31 |
| DE2407744A1 (de) | 1974-08-29 |
| CA1025856A (en) | 1978-02-07 |
| FR2218896A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-09-20 |
| ZA74883B (en) | 1974-12-24 |
| NL7402613A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-08-28 |
| GB1433774A (en) | 1976-04-28 |
| BE811246A (fr) | 1974-08-19 |
| JPS5029574A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-03-25 |
| ATA149974A (de) | 1975-08-15 |
| AU6559274A (en) | 1975-08-14 |
| AU474797B2 (en) | 1976-08-05 |
| IE38886L (en) | 1974-08-26 |
| LU69479A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-05-21 |
| AT329562B (de) | 1976-05-25 |
| SE7401984L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-08-27 |
| FR2218896B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-09-09 |
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