IE37773B1 - New 1,4-dihydropyridines their production and their medicinal use - Google Patents
New 1,4-dihydropyridines their production and their medicinal useInfo
- Publication number
- IE37773B1 IE37773B1 IE932/73A IE93273A IE37773B1 IE 37773 B1 IE37773 B1 IE 37773B1 IE 932/73 A IE932/73 A IE 932/73A IE 93273 A IE93273 A IE 93273A IE 37773 B1 IE37773 B1 IE 37773B1
- Authority
- IE
- Ireland
- Prior art keywords
- beta
- dihydropyridines
- new
- production
- phenyl
- Prior art date
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000001412 amines Chemical class 0.000 abstract 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
- -1 4-substituted phenyl 1,4-dihydropyridine 3,5-dicarboxylic acids Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940125692 cardiovascular agent Drugs 0.000 abstract 1
- 239000002327 cardiovascular agent Substances 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- WULHJCJLAQZNNJ-UHFFFAOYSA-N diethyl 4-[2-[2-(diethylamino)ethoxy]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1C1=CC=CC=C1OCCN(CC)CC WULHJCJLAQZNNJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000002081 enamines Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2228363A DE2228363A1 (de) | 1972-06-10 | 1972-06-10 | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37773L IE37773L (en) | 1973-12-10 |
| IE37773B1 true IE37773B1 (en) | 1977-10-12 |
Family
ID=5847399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE932/73A IE37773B1 (en) | 1972-06-10 | 1973-06-08 | New 1,4-dihydropyridines their production and their medicinal use |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US3923818A (OSRAM) |
| JP (1) | JPS4948680A (OSRAM) |
| AT (2) | AT328447B (OSRAM) |
| AU (1) | AU473996B2 (OSRAM) |
| BE (1) | BE800679A (OSRAM) |
| CA (1) | CA999592A (OSRAM) |
| CH (7) | CH591444A5 (OSRAM) |
| CS (5) | CS178899B2 (OSRAM) |
| DD (1) | DD109383A5 (OSRAM) |
| DE (1) | DE2228363A1 (OSRAM) |
| ES (5) | ES415749A1 (OSRAM) |
| FR (1) | FR2187347B1 (OSRAM) |
| GB (1) | GB1425059A (OSRAM) |
| HU (1) | HU166354B (OSRAM) |
| IE (1) | IE37773B1 (OSRAM) |
| IL (1) | IL42458A (OSRAM) |
| NL (1) | NL7308059A (OSRAM) |
| SU (5) | SU511856A3 (OSRAM) |
| ZA (1) | ZA733880B (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3981882A (en) * | 1972-08-31 | 1976-09-21 | Bayer Aktiengesellschaft | Process for preparing 4-aryl of hetero-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid ester |
| US3971796A (en) * | 1973-07-12 | 1976-07-27 | Bayer Aktiengesellschaft | 1,4-Dihydropyridine esters |
| US4466972A (en) * | 1977-06-20 | 1984-08-21 | Sandoz Ltd. | Benzoxadiazoles and benzothiadiazoles, their preparation and pharmaceutical compositions containing them |
| DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4252956A (en) * | 1979-03-19 | 1981-02-24 | Vigante Brigita A | Derivatives of 1,4-dihydropyridine-3-carbothiol acids |
| GB2111978B (en) * | 1981-10-19 | 1985-05-01 | Maruko Pharmaceutical Co | 1 4-dihydropyridine compounds |
| DE3207982A1 (de) * | 1982-03-05 | 1983-09-08 | Bayer Ag, 5090 Leverkusen | Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln |
| IE57810B1 (en) * | 1984-03-27 | 1993-04-21 | Delagrange Lab | 1,4-dihydropyridine derivatives,their preparation and their use |
| NZ212895A (en) * | 1984-08-22 | 1988-07-28 | Glaxo Spa | 1,4-dihydropyridine derivatives and pharmaceutical compositions |
| JPS60210640A (ja) * | 1984-10-05 | 1985-10-23 | Hitachi Chem Co Ltd | 積層板の製造法 |
| GB8503429D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Chemical compounds |
| GB8503425D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Alkanolamine derivatives |
| GB8503427D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Basic compounds |
| GB8503428D0 (en) * | 1985-02-11 | 1985-03-13 | Ici Plc | Nitrogen-containing compounds |
| US4593033A (en) * | 1985-04-24 | 1986-06-03 | Merck & Co., Inc. | Substituted indeno[2,1-c] pyridines useful as calcium channel blockers |
| US4605660A (en) * | 1985-06-03 | 1986-08-12 | Merck & Co., Inc. | Indeno[2,1-c]pyridine compounds, and their use as calcium channel blockers |
| US4670443A (en) * | 1985-07-02 | 1987-06-02 | Merck & Co., Inc. | Benzo(f)isoquinoline compounds useful as calcium entry blockers |
| DK397686A (da) * | 1985-08-21 | 1987-02-22 | Glaxo Spa | Heterocycliske forbindelser |
| DE3675747D1 (de) * | 1985-08-21 | 1991-01-03 | Glaxo Spa | 1,4-dihydropyridinverbindungen und ihre herstellung und pharmazeutische formulierung. |
| US4735956A (en) * | 1985-09-13 | 1988-04-05 | Merck & Co., Inc. | Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers |
| US4788203A (en) * | 1985-11-26 | 1988-11-29 | Merck & Co., Inc. | Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders |
| US4721708A (en) * | 1985-11-26 | 1988-01-26 | Merck & Co., Inc. | Cyclized N-substituted-tetrahydropyridine compounds and cardiovascular use |
| IT1204460B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
| IT1204462B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
| EP0330470A3 (en) * | 1988-02-24 | 1992-01-02 | Ajinomoto Co., Inc. | 1,4-dihydropyridine derivatives useful against tumour cells |
| US5216172A (en) * | 1988-02-24 | 1993-06-01 | Ajinomoto Co., Inc. | 1,4-dihydropyridine-4-aryl-2,6-dimethyl-3,5-dicarboxylates useful as agents against drug resistant tumor cells |
| FR2672890A1 (fr) * | 1991-02-20 | 1992-08-21 | Inst Investigacion Desarrol | Derives de 2,6-dimethyl-4-(4'-hydroxy-3',5'-di-t-butylphenyl)-1,4-dihydropyridine, leur procede de preparation et leur utilisation comme capteurs de radicaux libres. |
| EP1108710A4 (en) * | 1998-07-23 | 2001-11-21 | Chen Ing Jun | GUAIACOXYPROPANOLAMINE WITH ALPHA / BETA ADRENERGIC INHIBIT ACTIVITY |
| US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| US20030153773A1 (en) * | 2002-02-14 | 2003-08-14 | Wayne Gregory S. | Process for the production of dihydropyridines |
| WO2005016885A2 (en) * | 2003-08-14 | 2005-02-24 | Artesian Therapeutics, Inc. | COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE |
| CN101287411B (zh) | 2005-04-28 | 2013-03-06 | 普罗秋斯生物医学公司 | 药物信息系统及其用途 |
| CN101594878A (zh) | 2006-09-18 | 2009-12-02 | 雷普特药品公司 | 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗 |
| ES2728225T3 (es) | 2009-02-20 | 2019-10-23 | 2 Bbb Medicines B V | Sistema de administración de fármacos a base de glutatión |
| KR101909711B1 (ko) | 2009-05-06 | 2018-12-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1923990C3 (de) * | 1969-05-10 | 1978-11-23 | Bayer Ag | Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern |
| DE2003146A1 (de) * | 1970-01-24 | 1971-07-29 | Bayer Ag | Neue 1,4-Dihydropyridinderivate |
-
1972
- 1972-06-10 DE DE2228363A patent/DE2228363A1/de active Pending
-
1973
- 1973-05-31 SU SU1926944A patent/SU511856A3/ru active
- 1973-06-04 US US366578A patent/US3923818A/en not_active Expired - Lifetime
- 1973-06-07 IL IL7342458A patent/IL42458A/en unknown
- 1973-06-07 HU HUBA2938A patent/HU166354B/hu unknown
- 1973-06-07 JP JP48063442A patent/JPS4948680A/ja active Pending
- 1973-06-07 CA CA173,419A patent/CA999592A/en not_active Expired
- 1973-06-08 NL NL7308059A patent/NL7308059A/xx not_active Application Discontinuation
- 1973-06-08 CH CH250377A patent/CH591444A5/xx not_active IP Right Cessation
- 1973-06-08 CS CS7600001304A patent/CS178899B2/cs unknown
- 1973-06-08 CS CS7600001302A patent/CS178897B2/cs unknown
- 1973-06-08 CH CH836973A patent/CH591443A5/xx not_active IP Right Cessation
- 1973-06-08 AU AU56725/73A patent/AU473996B2/en not_active Expired
- 1973-06-08 CH CH725676A patent/CH588462A5/xx not_active IP Right Cessation
- 1973-06-08 FR FR7320978A patent/FR2187347B1/fr not_active Expired
- 1973-06-08 BE BE132064A patent/BE800679A/xx unknown
- 1973-06-08 CH CH725976A patent/CH589629A5/xx not_active IP Right Cessation
- 1973-06-08 IE IE932/73A patent/IE37773B1/xx unknown
- 1973-06-08 CS CS7300004161A patent/CS178888B2/cs unknown
- 1973-06-08 DD DD171438A patent/DD109383A5/xx unknown
- 1973-06-08 ZA ZA733880A patent/ZA733880B/xx unknown
- 1973-06-08 CH CH250477A patent/CH589058A5/xx not_active IP Right Cessation
- 1973-06-08 CH CH725876A patent/CH589628A5/xx not_active IP Right Cessation
- 1973-06-08 AT AT507473A patent/AT328447B/de not_active IP Right Cessation
- 1973-06-08 CS CS7600001303A patent/CS178898B2/cs unknown
- 1973-06-08 CH CH725776A patent/CH593260A5/xx not_active IP Right Cessation
- 1973-06-08 AT AT177075*7A patent/AT329561B/de not_active IP Right Cessation
- 1973-06-08 GB GB2746373A patent/GB1425059A/en not_active Expired
- 1973-06-08 CS CS7600001305A patent/CS178900B2/cs unknown
- 1973-06-09 ES ES415749A patent/ES415749A1/es not_active Expired
-
1974
- 1974-06-27 SU SU2038435A patent/SU507234A3/ru active
- 1974-06-27 SU SU2038430A patent/SU510997A3/ru active
- 1974-07-23 SU SU2050564A patent/SU512708A3/ru active
- 1974-07-23 SU SU2050563A patent/SU509221A3/ru active
-
1975
- 1975-09-01 ES ES440622A patent/ES440622A1/es not_active Expired
- 1975-09-01 ES ES440621A patent/ES440621A1/es not_active Expired
- 1975-09-01 ES ES440619A patent/ES440619A1/es not_active Expired
- 1975-09-01 ES ES440620A patent/ES440620A1/es not_active Expired
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