IE36983B1 - Alpha-aryl-4-substituted 1-piperidinealkanol derivatives - Google Patents

Alpha-aryl-4-substituted 1-piperidinealkanol derivatives

Info

Publication number
IE36983B1
IE36983B1 IE1689/72A IE168972A IE36983B1 IE 36983 B1 IE36983 B1 IE 36983B1 IE 1689/72 A IE1689/72 A IE 1689/72A IE 168972 A IE168972 A IE 168972A IE 36983 B1 IE36983 B1 IE 36983B1
Authority
IE
Ireland
Prior art keywords
alkyl
aerosol
piperidinobutanol
phenylbenzyl
dichlorodifluoromethane
Prior art date
Application number
IE1689/72A
Other versions
IE36983L (en
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22829539&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IE36983(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of IE36983L publication Critical patent/IE36983L/en
Publication of IE36983B1 publication Critical patent/IE36983B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Abstract

1413138 Aerosol pharmaceutical compositions RICHARDSON-MERRELL Inc 15 Dec 1972 [28 Jan 1972] 57995/72 Heading C4X [Also in Division C2] Pharmaceutical compositions in the form of aerosols comprise a compound of Formula I in which R is H or OH; R<SP>1</SP> is H or R and R<SP>1</SP> form a second bond; n is 1-3; and Z is thienyl or phenyl, optionally substituted by halo, 1-4C alkyl, 1-4C alkoxy, di(1-4C alkyl). amino, pyrrolidino, piperidino, morpholino or N-(1-4C alkyl)piperazino; and a gaseous or liquefied propellant such as Cl 2 CF 2 optionally mixed with C 2 H 2 Cl 2 F 2 , together with any cosolvents or wetting agents as may be necessary. Example 16 discloses an aerosol solution consisting of 5% by wt. 4-(α-hydroxy-α-phenylbenzyl) - α - (p - fluorophenyl) - 1 - piperidinobutanol, 35% ethanol and 60% dichlorodifluoromethane, and Example 17 an aerosol suspension consisting of 20% by wt. 4-(α-hydroxy-α- phenylbenzyl) - α - (2 - thienyl) - 1 - piperidinobutanol, 0À5% sorbitan trioleate, and 39À75% each of dichlorodifluoroethane and dichlorodifluoromethane. [GB1413138A]
IE1689/72A 1972-01-28 1972-12-05 Alpha-aryl-4-substituted 1-piperidinealkanol derivatives IE36983B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22182172A 1972-01-28 1972-01-28

Publications (2)

Publication Number Publication Date
IE36983L IE36983L (en) 1973-07-28
IE36983B1 true IE36983B1 (en) 1977-04-13

Family

ID=22829539

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1689/72A IE36983B1 (en) 1972-01-28 1972-12-05 Alpha-aryl-4-substituted 1-piperidinealkanol derivatives

Country Status (26)

Country Link
JP (1) JPS5115035B2 (en)
AR (1) AR195314A1 (en)
AT (2) AT321917B (en)
AU (1) AU467361B2 (en)
BE (1) BE794597A (en)
CA (1) CA978946A (en)
CH (2) CH587820A5 (en)
CS (1) CS177834B2 (en)
DD (1) DD103239A5 (en)
DE (1) DE2303306C3 (en)
DK (1) DK136713B (en)
ES (1) ES410731A1 (en)
FR (1) FR2181690B1 (en)
GB (1) GB1413138A (en)
HU (1) HU166477B (en)
IE (1) IE36983B1 (en)
IL (1) IL41060A (en)
LU (1) LU66916A1 (en)
NL (1) NL175410C (en)
NO (1) NO140057C (en)
PH (1) PH10264A (en)
PL (1) PL89095B1 (en)
SE (1) SE382058B (en)
SU (1) SU464997A3 (en)
YU (1) YU36013B (en)
ZA (1) ZA728544B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941795A (en) 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4254130A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
IT1200123B (en) * 1985-09-27 1989-01-05 Ind Chimica Srl PROCESS FOR ALPHA PREPARATION
US4742175A (en) * 1986-05-07 1988-05-03 Merrell Dow Pharmaceuticals Inc. Preparation of polymorphically pure terfenadine
JPS63101760U (en) * 1986-12-19 1988-07-02
IT1205685B (en) * 1987-05-26 1989-03-31 Erregierre Spa PROCESS FOR THE PREPARATION OF ALPHA- (ALCHYLPHENYL) -4- (HYDROXY DIPHENYLMETHYL) -1-PIPERIDINE BUTANOL
IL93499A0 (en) * 1989-02-28 1990-11-29 Merrell Dow Pharma Preparation of the low melting polymorphic form of terfenadine
ZA903145B (en) * 1989-05-01 1991-02-27 Merrell Dow Pharma Process for the preparation of the high melting polymorphic form of terfenadine
DE3917241A1 (en) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4- (HYDROXYDIPHENYLMETHYL) -1-PIPERIDYL-PHENYLALKANE DERIVATIVES
US5466691A (en) * 1991-08-09 1995-11-14 Yoshitomi Pharmaceutical Industries, Ltd. Thiophene compound
JPH11504650A (en) * 1995-05-08 1999-04-27 ヘキスト・マリオン・ルセル・インコーポレイテツド Alpha- (substituted alkylphenyl) -4- (hydroxydiphenylmethyl) -1-piperidinebutanol derivatives, their preparation and their use as antihistamines, antiallergic agents and bronchodilators
ES2216191T3 (en) * 1997-03-11 2004-10-16 Aventis Pharmaceuticals Inc. PROCEDURE FOR PREPARING ACID 4- (4- (HYDROXIDIFENYL) -1-PIPERIDINYL) -1-HYDROXIBUTE) -ALFA, ALPHA-DIMETHYLPHENYLACETIC AND PHOSPHORILE DERIVATIVES.
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US8153385B2 (en) 2004-10-18 2012-04-10 Reverse Proteomics Research Institute Co., Ltd. Target protein and target gene in drug designing and screening method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3081303A (en) * 1961-10-13 1963-03-12 Searle & Co 1-aminoalkyl-alpha, alpha-diphenylpiperidine-methanols
GB1242169A (en) * 1969-04-09 1971-08-11 Ucb Sa Piperidine derivatives

Also Published As

Publication number Publication date
HU166477B (en) 1975-03-28
CS177834B2 (en) 1977-08-31
AT321917B (en) 1975-04-25
NO140057B (en) 1979-03-19
BE794597A (en) 1973-05-16
AT323742B (en) 1975-07-25
PL89095B1 (en) 1976-10-30
JPS4885578A (en) 1973-11-13
NL175410C (en) 1984-11-01
AU4989372A (en) 1974-06-13
NO140057C (en) 1979-07-04
LU66916A1 (en) 1973-07-27
JPS5115035B2 (en) 1976-05-13
DK136713C (en) 1978-05-01
DE2303306C3 (en) 1979-05-31
YU3473A (en) 1981-02-28
IL41060A0 (en) 1973-02-28
NL7300873A (en) 1973-07-31
AU467361B2 (en) 1975-11-27
ZA728544B (en) 1974-02-27
FR2181690B1 (en) 1976-05-14
CH593259A5 (en) 1977-11-30
DK136713B (en) 1977-11-14
FR2181690A1 (en) 1973-12-07
PH10264A (en) 1976-10-20
YU36013B (en) 1981-11-13
SU464997A3 (en) 1975-03-25
DE2303306B2 (en) 1978-09-28
CH587820A5 (en) 1977-05-13
IL41060A (en) 1975-06-25
ES410731A1 (en) 1976-04-01
AR195314A1 (en) 1973-09-28
IE36983L (en) 1973-07-28
DE2303306A1 (en) 1973-08-02
SE382058B (en) 1976-01-12
NL175410B (en) 1984-06-01
GB1413138A (en) 1975-11-05
CA978946A (en) 1975-12-02
DD103239A5 (en) 1974-01-12

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