GB1413138A - Alpha-aryl-4-substituted piperidinoalkanol derivatives - Google Patents

Alpha-aryl-4-substituted piperidinoalkanol derivatives

Info

Publication number
GB1413138A
GB1413138A GB5799572A GB5799572A GB1413138A GB 1413138 A GB1413138 A GB 1413138A GB 5799572 A GB5799572 A GB 5799572A GB 5799572 A GB5799572 A GB 5799572A GB 1413138 A GB1413138 A GB 1413138A
Authority
GB
United Kingdom
Prior art keywords
alkyl
aerosol
aryl
alpha
piperidinobutanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5799572A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22829539&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1413138(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of GB1413138A publication Critical patent/GB1413138A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Abstract

1413138 Aerosol pharmaceutical compositions RICHARDSON-MERRELL Inc 15 Dec 1972 [28 Jan 1972] 57995/72 Heading C4X [Also in Division C2] Pharmaceutical compositions in the form of aerosols comprise a compound of Formula I in which R is H or OH; R<SP>1</SP> is H or R and R<SP>1</SP> form a second bond; n is 1-3; and Z is thienyl or phenyl, optionally substituted by halo, 1-4C alkyl, 1-4C alkoxy, di(1-4C alkyl). amino, pyrrolidino, piperidino, morpholino or N-(1-4C alkyl)piperazino; and a gaseous or liquefied propellant such as Cl 2 CF 2 optionally mixed with C 2 H 2 Cl 2 F 2 , together with any cosolvents or wetting agents as may be necessary. Example 16 discloses an aerosol solution consisting of 5% by wt. 4-(α-hydroxy-α-phenylbenzyl) - α - (p - fluorophenyl) - 1 - piperidinobutanol, 35% ethanol and 60% dichlorodifluoromethane, and Example 17 an aerosol suspension consisting of 20% by wt. 4-(α-hydroxy-α- phenylbenzyl) - α - (2 - thienyl) - 1 - piperidinobutanol, 0À5% sorbitan trioleate, and 39À75% each of dichlorodifluoroethane and dichlorodifluoromethane.
GB5799572A 1972-01-28 1972-12-15 Alpha-aryl-4-substituted piperidinoalkanol derivatives Expired GB1413138A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22182172A 1972-01-28 1972-01-28

Publications (1)

Publication Number Publication Date
GB1413138A true GB1413138A (en) 1975-11-05

Family

ID=22829539

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5799572A Expired GB1413138A (en) 1972-01-28 1972-12-15 Alpha-aryl-4-substituted piperidinoalkanol derivatives

Country Status (26)

Country Link
JP (1) JPS5115035B2 (en)
AR (1) AR195314A1 (en)
AT (2) AT321917B (en)
AU (1) AU467361B2 (en)
BE (1) BE794597A (en)
CA (1) CA978946A (en)
CH (2) CH587820A5 (en)
CS (1) CS177834B2 (en)
DD (1) DD103239A5 (en)
DE (1) DE2303306C3 (en)
DK (1) DK136713B (en)
ES (1) ES410731A1 (en)
FR (1) FR2181690B1 (en)
GB (1) GB1413138A (en)
HU (1) HU166477B (en)
IE (1) IE36983B1 (en)
IL (1) IL41060A (en)
LU (1) LU66916A1 (en)
NL (1) NL175410C (en)
NO (1) NO140057C (en)
PH (1) PH10264A (en)
PL (1) PL89095B1 (en)
SE (1) SE382058B (en)
SU (1) SU464997A3 (en)
YU (1) YU36013B (en)
ZA (1) ZA728544B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0385375A1 (en) * 1989-02-28 1990-09-05 Merrell Dow Pharmaceuticals Inc. Preparation of the low melting polymorphic form of terfenadine
US5466691A (en) * 1991-08-09 1995-11-14 Yoshitomi Pharmaceutical Industries, Ltd. Thiophene compound

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941795A (en) 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4254130A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
IT1200123B (en) * 1985-09-27 1989-01-05 Ind Chimica Srl PROCESS FOR ALPHA PREPARATION
US4742175A (en) * 1986-05-07 1988-05-03 Merrell Dow Pharmaceuticals Inc. Preparation of polymorphically pure terfenadine
JPS63101760U (en) * 1986-12-19 1988-07-02
IT1205685B (en) * 1987-05-26 1989-03-31 Erregierre Spa PROCESS FOR THE PREPARATION OF ALPHA- (ALCHYLPHENYL) -4- (HYDROXY DIPHENYLMETHYL) -1-PIPERIDINE BUTANOL
ZA903145B (en) * 1989-05-01 1991-02-27 Merrell Dow Pharma Process for the preparation of the high melting polymorphic form of terfenadine
DE3917241A1 (en) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4- (HYDROXYDIPHENYLMETHYL) -1-PIPERIDYL-PHENYLALKANE DERIVATIVES
JPH11504650A (en) * 1995-05-08 1999-04-27 ヘキスト・マリオン・ルセル・インコーポレイテツド Alpha- (substituted alkylphenyl) -4- (hydroxydiphenylmethyl) -1-piperidinebutanol derivatives, their preparation and their use as antihistamines, antiallergic agents and bronchodilators
ES2216191T3 (en) * 1997-03-11 2004-10-16 Aventis Pharmaceuticals Inc. PROCEDURE FOR PREPARING ACID 4- (4- (HYDROXIDIFENYL) -1-PIPERIDINYL) -1-HYDROXIBUTE) -ALFA, ALPHA-DIMETHYLPHENYLACETIC AND PHOSPHORILE DERIVATIVES.
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US8153385B2 (en) 2004-10-18 2012-04-10 Reverse Proteomics Research Institute Co., Ltd. Target protein and target gene in drug designing and screening method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3081303A (en) * 1961-10-13 1963-03-12 Searle & Co 1-aminoalkyl-alpha, alpha-diphenylpiperidine-methanols
GB1242169A (en) * 1969-04-09 1971-08-11 Ucb Sa Piperidine derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0385375A1 (en) * 1989-02-28 1990-09-05 Merrell Dow Pharmaceuticals Inc. Preparation of the low melting polymorphic form of terfenadine
US5466691A (en) * 1991-08-09 1995-11-14 Yoshitomi Pharmaceutical Industries, Ltd. Thiophene compound

Also Published As

Publication number Publication date
HU166477B (en) 1975-03-28
CS177834B2 (en) 1977-08-31
AT321917B (en) 1975-04-25
NO140057B (en) 1979-03-19
BE794597A (en) 1973-05-16
AT323742B (en) 1975-07-25
PL89095B1 (en) 1976-10-30
JPS4885578A (en) 1973-11-13
NL175410C (en) 1984-11-01
AU4989372A (en) 1974-06-13
NO140057C (en) 1979-07-04
LU66916A1 (en) 1973-07-27
JPS5115035B2 (en) 1976-05-13
DK136713C (en) 1978-05-01
DE2303306C3 (en) 1979-05-31
IE36983B1 (en) 1977-04-13
YU3473A (en) 1981-02-28
IL41060A0 (en) 1973-02-28
NL7300873A (en) 1973-07-31
AU467361B2 (en) 1975-11-27
ZA728544B (en) 1974-02-27
FR2181690B1 (en) 1976-05-14
CH593259A5 (en) 1977-11-30
DK136713B (en) 1977-11-14
FR2181690A1 (en) 1973-12-07
PH10264A (en) 1976-10-20
YU36013B (en) 1981-11-13
SU464997A3 (en) 1975-03-25
DE2303306B2 (en) 1978-09-28
CH587820A5 (en) 1977-05-13
IL41060A (en) 1975-06-25
ES410731A1 (en) 1976-04-01
AR195314A1 (en) 1973-09-28
IE36983L (en) 1973-07-28
DE2303306A1 (en) 1973-08-02
SE382058B (en) 1976-01-12
NL175410B (en) 1984-06-01
CA978946A (en) 1975-12-02
DD103239A5 (en) 1974-01-12

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746D Case decided by the comptroller (sect. 46(3)/1977)
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
746B Proceeding under section 46(3) patents act 1977
771F Application withdrawn (sect. 71/1977) [non-infrigement]
PE20 Patent expired after termination of 20 years

Effective date: 19921214