IE36944B1 - 17alpha-ethynylestriols and process for preparing same - Google Patents
17alpha-ethynylestriols and process for preparing sameInfo
- Publication number
- IE36944B1 IE36944B1 IE295/72A IE29572A IE36944B1 IE 36944 B1 IE36944 B1 IE 36944B1 IE 295/72 A IE295/72 A IE 295/72A IE 29572 A IE29572 A IE 29572A IE 36944 B1 IE36944 B1 IE 36944B1
- Authority
- IE
- Ireland
- Prior art keywords
- cycloalkyl
- compound
- mixture
- ether
- ethynylestriols
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- -1 alkali metal alkoxide Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 abstract 1
- DRSHXJFUUPIBHX-UHFFFAOYSA-N COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 Chemical compound COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 DRSHXJFUUPIBHX-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- BOTLEXFFFSMRLQ-UHFFFAOYSA-N cyclopentyloxycyclopentane Chemical compound C1CCCC1OC1CCCC1 BOTLEXFFFSMRLQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 229960003399 estrone Drugs 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- DZFYOYRNBGNPJW-UHFFFAOYSA-N ethoxythallium Chemical compound [Tl+].CC[O-] DZFYOYRNBGNPJW-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12769071A | 1971-03-24 | 1971-03-24 | |
| US127771A US3697558A (en) | 1971-03-24 | Preparation of 17alpha-ethynylestriol | |
| US00134420A US3813419A (en) | 1971-03-24 | 1971-04-15 | Preparation of phenolic ethers |
| US13667171A | 1971-04-23 | 1971-04-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36944L IE36944L (en) | 1972-09-25 |
| IE36944B1 true IE36944B1 (en) | 1977-03-30 |
Family
ID=27494695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE295/72A IE36944B1 (en) | 1971-03-24 | 1972-03-08 | 17alpha-ethynylestriols and process for preparing same |
Country Status (14)
| Country | Link |
|---|---|
| AU (1) | AU461293B2 (OSRAM) |
| BE (1) | BE781099A (OSRAM) |
| CA (1) | CA973871A (OSRAM) |
| CS (1) | CS173592B2 (OSRAM) |
| DD (1) | DD95567A5 (OSRAM) |
| DE (1) | DE2213482A1 (OSRAM) |
| FR (1) | FR2130683B1 (OSRAM) |
| GB (1) | GB1336703A (OSRAM) |
| IE (1) | IE36944B1 (OSRAM) |
| IL (1) | IL38952A (OSRAM) |
| NL (1) | NL7204019A (OSRAM) |
| PL (1) | PL75312B2 (OSRAM) |
| SE (1) | SE378427B (OSRAM) |
| ZA (1) | ZA721523B (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109721634B (zh) * | 2019-01-24 | 2021-08-03 | 上海新华联制药有限公司 | 一种尼尔雌醇的合成工艺 |
| CN109705182B (zh) * | 2019-01-24 | 2021-08-31 | 上海新华联制药有限公司 | 一种尼尔雌醇的制备方法 |
-
1972
- 1972-03-07 ZA ZA721523A patent/ZA721523B/xx unknown
- 1972-03-08 IE IE295/72A patent/IE36944B1/xx unknown
- 1972-03-09 AU AU39827/72A patent/AU461293B2/en not_active Expired
- 1972-03-10 IL IL38952A patent/IL38952A/en unknown
- 1972-03-15 CA CA137,140A patent/CA973871A/en not_active Expired
- 1972-03-20 DE DE19722213482 patent/DE2213482A1/de active Pending
- 1972-03-21 SE SE7203607A patent/SE378427B/xx unknown
- 1972-03-22 PL PL15422772A patent/PL75312B2/pl unknown
- 1972-03-23 GB GB1352372A patent/GB1336703A/en not_active Expired
- 1972-03-23 BE BE781099A patent/BE781099A/xx unknown
- 1972-03-24 FR FR7210470A patent/FR2130683B1/fr not_active Expired
- 1972-03-24 NL NL7204019A patent/NL7204019A/xx unknown
- 1972-03-24 DD DD161848A patent/DD95567A5/xx unknown
- 1972-03-24 CS CS1983A patent/CS173592B2/cs unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2213482A1 (de) | 1972-09-28 |
| IL38952A (en) | 1976-04-30 |
| CS173592B2 (OSRAM) | 1977-02-28 |
| NL7204019A (OSRAM) | 1972-09-26 |
| FR2130683A1 (OSRAM) | 1972-11-03 |
| IL38952A0 (en) | 1972-05-30 |
| AU3982772A (en) | 1973-09-13 |
| GB1336703A (en) | 1973-11-07 |
| IE36944L (en) | 1972-09-25 |
| SE378427B (OSRAM) | 1975-09-01 |
| DD95567A5 (OSRAM) | 1973-02-12 |
| PL75312B2 (en) | 1974-12-31 |
| FR2130683B1 (OSRAM) | 1976-04-16 |
| ZA721523B (en) | 1973-10-31 |
| AU461293B2 (en) | 1975-05-22 |
| BE781099A (fr) | 1972-09-25 |
| CA973871A (en) | 1975-09-02 |
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