IE36841B1 - 10-piperazinyl - dibenzo - (b,f.) thiepins, methods for their preparation and compositions containing them - Google Patents
10-piperazinyl - dibenzo - (b,f.) thiepins, methods for their preparation and compositions containing themInfo
- Publication number
- IE36841B1 IE36841B1 IE1579/72A IE157972A IE36841B1 IE 36841 B1 IE36841 B1 IE 36841B1 IE 1579/72 A IE1579/72 A IE 1579/72A IE 157972 A IE157972 A IE 157972A IE 36841 B1 IE36841 B1 IE 36841B1
- Authority
- IE
- Ireland
- Prior art keywords
- nitro
- hydrogen
- alkyl
- dibenzo
- prepared
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- ZPIKDLQSPNLHNQ-UHFFFAOYSA-N 2-(3-chlorophenyl)sulfanyl-5-nitrobenzaldehyde Chemical compound O=CC1=CC([N+](=O)[O-])=CC=C1SC1=CC=CC(Cl)=C1 ZPIKDLQSPNLHNQ-UHFFFAOYSA-N 0.000 abstract 1
- VFVHWCKUHAEDMY-UHFFFAOYSA-N 2-chloro-5-nitrobenzaldehyde Chemical compound [O-][N+](=O)C1=CC=C(Cl)C(C=O)=C1 VFVHWCKUHAEDMY-UHFFFAOYSA-N 0.000 abstract 1
- NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 abstract 1
- IEIUIKHMVGQHBH-UHFFFAOYSA-N 6h-benzo[b][1]benzothiepin-5-one Chemical compound O=C1CC2=CC=CC=C2SC2=CC=CC=C12 IEIUIKHMVGQHBH-UHFFFAOYSA-N 0.000 abstract 1
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- OKJIRPAQVSHGFK-UHFFFAOYSA-N N-acetylglycine Chemical compound CC(=O)NCC(O)=O OKJIRPAQVSHGFK-UHFFFAOYSA-N 0.000 abstract 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 cyano, carboxy Chemical group 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960003424 phenylacetic acid Drugs 0.000 abstract 1
- 239000003279 phenylacetic acid Substances 0.000 abstract 1
- 229920000137 polyphosphoric acid Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000004728 pyruvic acid derivatives Chemical class 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19933371A | 1971-11-16 | 1971-11-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36841L IE36841L (en) | 1973-05-16 |
| IE36841B1 true IE36841B1 (en) | 1977-03-02 |
Family
ID=22737104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1579/72A IE36841B1 (en) | 1971-11-16 | 1972-11-16 | 10-piperazinyl - dibenzo - (b,f.) thiepins, methods for their preparation and compositions containing them |
Country Status (12)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL62705A (en) * | 1980-04-25 | 1986-04-29 | Sparamedica Ag | Topical anti-inflammatory pharmaceutical compositions containing piperazine derivatives |
| DE3367211D1 (en) * | 1982-08-06 | 1986-12-04 | Boots Co Plc | Therapeutic agent |
| JPH0655714B2 (ja) * | 1985-05-09 | 1994-07-27 | 藤沢薬品工業株式会社 | ジフエニルチオエ−テル誘導体の製造法 |
| US6423708B1 (en) * | 1996-09-30 | 2002-07-23 | Pfizer Inc | Aralkyl and aralkylidene heterocyclic lactams and imides |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH539044A (de) * | 1967-10-06 | 1973-08-31 | Gnii Orch Poluproduktov I Kras | Verfahren zur Herstellung quaternärer Ammoniumsalze von 1,3-Bis-(aminomethyl)-imidazolidonen |
-
0
- BE BE791348D patent/BE791348A/xx unknown
-
1972
- 1972-09-25 ZA ZA726537A patent/ZA726537B/xx unknown
- 1972-10-12 NL NL7213809A patent/NL7213809A/xx unknown
- 1972-10-27 DE DE2252806A patent/DE2252806A1/de active Pending
- 1972-11-14 IL IL40828A patent/IL40828A0/xx unknown
- 1972-11-15 ES ES408603A patent/ES408603A1/es not_active Expired
- 1972-11-15 AU AU48914/72A patent/AU4891472A/en not_active Expired
- 1972-11-15 JP JP47113977A patent/JPS4861490A/ja active Pending
- 1972-11-15 HU HUHO1525A patent/HU166241B/hu unknown
- 1972-11-16 FR FR7240727A patent/FR2160541B1/fr not_active Expired
- 1972-11-16 GB GB5297372A patent/GB1369525A/en not_active Expired
- 1972-11-16 IE IE1579/72A patent/IE36841B1/xx unknown
-
1973
- 1973-09-17 ES ES418811A patent/ES418811A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES418811A1 (es) | 1976-03-16 |
| IE36841L (en) | 1973-05-16 |
| IL40828A0 (en) | 1973-01-30 |
| DE2252806A1 (de) | 1973-05-24 |
| GB1369525A (en) | 1974-10-09 |
| ZA726537B (en) | 1973-06-27 |
| AU4891472A (en) | 1974-05-16 |
| BE791348A (fr) | 1973-05-14 |
| FR2160541A1 (enrdf_load_stackoverflow) | 1973-06-29 |
| JPS4861490A (enrdf_load_stackoverflow) | 1973-08-28 |
| FR2160541B1 (enrdf_load_stackoverflow) | 1975-10-31 |
| NL7213809A (enrdf_load_stackoverflow) | 1973-05-18 |
| ES408603A1 (es) | 1975-10-01 |
| HU166241B (enrdf_load_stackoverflow) | 1975-02-28 |
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