JPS55344A - 2-nitrosoiminobenzthiazoline derivative - Google Patents

2-nitrosoiminobenzthiazoline derivative

Info

Publication number
JPS55344A
JPS55344A JP14486178A JP14486178A JPS55344A JP S55344 A JPS55344 A JP S55344A JP 14486178 A JP14486178 A JP 14486178A JP 14486178 A JP14486178 A JP 14486178A JP S55344 A JPS55344 A JP S55344A
Authority
JP
Japan
Prior art keywords
chloro
hydroxyethyl
reacted
formula
carbonylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14486178A
Other languages
Japanese (ja)
Inventor
Tsugio Okada
Kazan Naito
Toshio Kikuchi
Masahiro Sugo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IWAKI SEIYAKU KK
Original Assignee
IWAKI SEIYAKU KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IWAKI SEIYAKU KK filed Critical IWAKI SEIYAKU KK
Priority to JP14486178A priority Critical patent/JPS55344A/en
Publication of JPS55344A publication Critical patent/JPS55344A/en
Pending legal-status Critical Current

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  • Thiazole And Isothizaole Compounds (AREA)

Abstract

NEW MATERIAL:5-chloro-3-[4-(2-hydroxyethyl)-1-piperazinyl]carbonylmethyl- 2-nitrosoiminobenzthiazoline shown by the formula I.
USE: A synthetic intermediate of 5-chloro-3-[4-(2-hydroxyethyl)-1-piperazinyl]carbonylmethyl-2-benzthiazolinone, a medicine having antiinflammatory and pain-killing effect.
PROCESS: m-Chloroaniline shown by the formula II is reacted with a thiocyanate (e.g., sodium salt) to give (3-chlorophenyl) thiourea, which is subjected to ring opening reaction by bromine to prepare 5-chloro-2-aminobenzthiazole (compound III). The compound III is reacted with a monohalogenated acetate to give 5-chloro- 2-iminobenzthiazoline-3-acetate shown by the formula IV (R is lower alkyl), which is reacted with 1-(2-hydroxyethyl) piperazine to prepare 5-chloro-3-[4-(2-hydroxyethyl)-1-piperazinyl]carbonylmethyl-2-iminobenzthiazoline. This compound is reacted with a nitrite (e.g., sodium salt) to give the compound shown by the formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP14486178A 1978-11-22 1978-11-22 2-nitrosoiminobenzthiazoline derivative Pending JPS55344A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14486178A JPS55344A (en) 1978-11-22 1978-11-22 2-nitrosoiminobenzthiazoline derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14486178A JPS55344A (en) 1978-11-22 1978-11-22 2-nitrosoiminobenzthiazoline derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP52101463A Division JPS5811951B2 (en) 1977-08-24 1977-08-24 Method for producing 2-benzothiazolinone derivative

Publications (1)

Publication Number Publication Date
JPS55344A true JPS55344A (en) 1980-01-05

Family

ID=15372096

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14486178A Pending JPS55344A (en) 1978-11-22 1978-11-22 2-nitrosoiminobenzthiazoline derivative

Country Status (1)

Country Link
JP (1) JPS55344A (en)

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