JPS55344A - 2-nitrosoiminobenzthiazoline derivative - Google Patents
2-nitrosoiminobenzthiazoline derivativeInfo
- Publication number
- JPS55344A JPS55344A JP14486178A JP14486178A JPS55344A JP S55344 A JPS55344 A JP S55344A JP 14486178 A JP14486178 A JP 14486178A JP 14486178 A JP14486178 A JP 14486178A JP S55344 A JPS55344 A JP S55344A
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- hydroxyethyl
- reacted
- formula
- carbonylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
Abstract
NEW MATERIAL:5-chloro-3-[4-(2-hydroxyethyl)-1-piperazinyl]carbonylmethyl- 2-nitrosoiminobenzthiazoline shown by the formula I.
USE: A synthetic intermediate of 5-chloro-3-[4-(2-hydroxyethyl)-1-piperazinyl]carbonylmethyl-2-benzthiazolinone, a medicine having antiinflammatory and pain-killing effect.
PROCESS: m-Chloroaniline shown by the formula II is reacted with a thiocyanate (e.g., sodium salt) to give (3-chlorophenyl) thiourea, which is subjected to ring opening reaction by bromine to prepare 5-chloro-2-aminobenzthiazole (compound III). The compound III is reacted with a monohalogenated acetate to give 5-chloro- 2-iminobenzthiazoline-3-acetate shown by the formula IV (R is lower alkyl), which is reacted with 1-(2-hydroxyethyl) piperazine to prepare 5-chloro-3-[4-(2-hydroxyethyl)-1-piperazinyl]carbonylmethyl-2-iminobenzthiazoline. This compound is reacted with a nitrite (e.g., sodium salt) to give the compound shown by the formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14486178A JPS55344A (en) | 1978-11-22 | 1978-11-22 | 2-nitrosoiminobenzthiazoline derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14486178A JPS55344A (en) | 1978-11-22 | 1978-11-22 | 2-nitrosoiminobenzthiazoline derivative |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52101463A Division JPS5811951B2 (en) | 1977-08-24 | 1977-08-24 | Method for producing 2-benzothiazolinone derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55344A true JPS55344A (en) | 1980-01-05 |
Family
ID=15372096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14486178A Pending JPS55344A (en) | 1978-11-22 | 1978-11-22 | 2-nitrosoiminobenzthiazoline derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55344A (en) |
-
1978
- 1978-11-22 JP JP14486178A patent/JPS55344A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8202546A1 (en) | Thiazolidine derivatives and their production and use. | |
JPS5681578A (en) | Novel thioalkyl amide derivative | |
JPS56103168A (en) | Thiazole derivative, its preparation, and antihistaminic agent containing the same | |
ES482675A1 (en) | New intermediates and their use for the preparation of new oxadiazolo-pyrimidine derivatives. | |
ES478485A1 (en) | 1-Oxo-1H-pyrimido (6,1-b) benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing them. | |
ES8401926A1 (en) | Hydroxybenzylamino-aryl compounds, process for preparing and pharmaceutical compositions containing the same. | |
JPS5562064A (en) | Isatin derivative | |
GB884760A (en) | Trifluoromethyl phenothiazines | |
JPS55344A (en) | 2-nitrosoiminobenzthiazoline derivative | |
JPS5651465A (en) | Benzothiazine derivative | |
JPS55345A (en) | 2-iminobenzthiazoline derivative | |
JPS5681574A (en) | Preparation of 2,2-disubstituted thiazolidine | |
JPS5756425A (en) | Hypotensor | |
JPS5576872A (en) | Imidazolidinone derivative | |
JPS5653658A (en) | Pharmaceutical composition having diuretic and hypotensive activity | |
JPS5690067A (en) | Novel heterocyclic ring substituted phenylacetic acid derivative | |
US4027030A (en) | Certain thiazole-carboxamides and their pharmaceutical utility | |
JPS54106495A (en) | Cephem derivative | |
JPS57123175A (en) | Preparation of thiazolidine derivative | |
JPS54109969A (en) | Novel method of preparing thiazole derivative | |
ZA816741B (en) | Acyl derivatives | |
JPS55124781A (en) | 1,4-benzdioxanesulfonamide derivative | |
JPS5692279A (en) | Thiazolidine derivative | |
JPS56115780A (en) | Phenoxyalkaneacid derivative substituted by heterocyclic ring containing nitrogen and sulfur, and its preparation | |
JPS57169480A (en) | Production of indole derivative |