IE36698B1 - New phenylimino-3-aza-1-thia-cycloalkanes their preparation and their medicinal use - Google Patents
New phenylimino-3-aza-1-thia-cycloalkanes their preparation and their medicinal useInfo
- Publication number
- IE36698B1 IE36698B1 IE1249/72A IE124972A IE36698B1 IE 36698 B1 IE36698 B1 IE 36698B1 IE 1249/72 A IE1249/72 A IE 1249/72A IE 124972 A IE124972 A IE 124972A IE 36698 B1 IE36698 B1 IE 36698B1
- Authority
- IE
- Ireland
- Prior art keywords
- phenylimino
- cycloalkanes
- thia
- aza
- preparation
- Prior art date
Links
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- CISSMTSOBLGEAJ-UHFFFAOYSA-N 4-[(3-methyl-1,3-thiazolidin-2-ylidene)amino]aniline Chemical compound CN1CCSC1=NC1=CC=C(N)C=C1 CISSMTSOBLGEAJ-UHFFFAOYSA-N 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 229940124339 anthelmintic agent Drugs 0.000 abstract 1
- 239000000921 anthelmintic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 150000003548 thiazolidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/18—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/20—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
2-(4-Aminophenylimino) derivatives of thiazolidine and -4H-5,6-dihydro-1,3-thiazines, the corresponding amide and sulfonamide derivatives, and the salts thereof are anthelmintic agents. The compounds, of which 2-(4-aminophenylimino)-N-methylthiazolidine is a typical embodiment, are prepared through cyclization of a thiourea, optionally with subsequent hydrolysis, alkylation or acetylation.
[US3860590A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2145807A DE2145807A1 (en) | 1971-09-14 | 1971-09-14 | 2- (AMINOPHENYLIMINO) -3-AZA-1-THIACYCLOALKANE, METHOD OF MANUFACTURING AND USE AS A MEDICINAL PRODUCT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36698L IE36698L (en) | 1973-03-14 |
| IE36698B1 true IE36698B1 (en) | 1977-02-02 |
Family
ID=5819465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1249/72A IE36698B1 (en) | 1971-09-14 | 1972-09-13 | New phenylimino-3-aza-1-thia-cycloalkanes their preparation and their medicinal use |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US3860590A (en) |
| JP (2) | JPS4836169A (en) |
| AT (1) | AT322548B (en) |
| AU (1) | AU464649B2 (en) |
| BE (1) | BE788743A (en) |
| CA (1) | CA1007638A (en) |
| CH (2) | CH587258A5 (en) |
| DD (2) | DD105990A5 (en) |
| DE (1) | DE2145807A1 (en) |
| EG (1) | EG11037A (en) |
| ES (4) | ES406622A1 (en) |
| FR (1) | FR2154512B1 (en) |
| GB (1) | GB1377265A (en) |
| HU (1) | HU167410B (en) |
| IE (1) | IE36698B1 (en) |
| IL (1) | IL40338A (en) |
| NL (1) | NL7212419A (en) |
| PL (4) | PL89701B1 (en) |
| RO (4) | RO84247B (en) |
| SE (1) | SE412756B (en) |
| SU (3) | SU505363A3 (en) |
| ZA (1) | ZA726271B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU167761B (en) * | 1973-07-12 | 1975-12-25 | ||
| US4163791A (en) * | 1976-09-17 | 1979-08-07 | Ciba-Geigy Corporation | 2-Phenyliminothiazoline compounds |
| IL52926A (en) * | 1976-09-17 | 1980-06-30 | Ciba Geigy Ag | 2-(n-methylcarbamoyloxyphenylimino)-thiazolidine derivatives,their production and their use as pesticides |
| DE2758005A1 (en) | 1977-12-24 | 1979-06-28 | Bayer Ag | PHOSPHONYLUREIDOBENZOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS |
| DE3632042A1 (en) * | 1986-03-08 | 1987-09-10 | Bayer Ag | DIARYLSULFID DERIVATIVES |
| US6353006B1 (en) | 1999-01-14 | 2002-03-05 | Bayer Corporation | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents |
| KR100509401B1 (en) | 1999-09-14 | 2005-08-22 | 시오노기세이야쿠가부시키가이샤 | 2-imino-1,3-thiazine derivatives |
| DE102008030764A1 (en) | 2008-06-28 | 2009-12-31 | Bayer Animal Health Gmbh | Combination of amidine derivatives with cyclic depsipeptides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US327708A (en) * | 1885-10-06 | Wet-ore concentrator | ||
| US2877232A (en) * | 1957-12-31 | 1959-03-10 | Ciba Pharm Prod Inc | 2-(4-isopentyloxyphenyl)-imino, 3 (4-isopentyloxyphenyl)-thiazolidine and therapeutically useful salts |
| US3297708A (en) * | 1965-10-06 | 1967-01-10 | American Cyanamid Co | Method of preparing thiazolidines |
| FR1516854A (en) * | 1966-12-20 | 1968-02-05 | Aquitaine Petrole | Process for the production of imino-thiazolidines |
-
0
- BE BE788743D patent/BE788743A/en unknown
-
1971
- 1971-09-14 DE DE2145807A patent/DE2145807A1/en active Pending
-
1972
- 1972-08-30 RO RO80696A patent/RO84247B/en unknown
- 1972-08-30 RO RO80697A patent/RO84248B/en unknown
- 1972-08-30 RO RO7280698A patent/RO68389A/en unknown
- 1972-08-30 RO RO7280695A patent/RO68372A/en unknown
- 1972-09-12 DD DD173372*A patent/DD105990A5/xx unknown
- 1972-09-12 IL IL40338A patent/IL40338A/en unknown
- 1972-09-12 EG EG371/72A patent/EG11037A/en active
- 1972-09-12 SU SU1827229A patent/SU505363A3/en active
- 1972-09-12 SU SU1827231A patent/SU455544A3/en active
- 1972-09-12 SU SU1827228A patent/SU556728A3/en active
- 1972-09-12 CH CH1020475A patent/CH587258A5/xx not_active IP Right Cessation
- 1972-09-12 DD DD165616A patent/DD103898A5/xx unknown
- 1972-09-12 CH CH1338372A patent/CH569724A5/xx not_active IP Right Cessation
- 1972-09-13 GB GB4255272A patent/GB1377265A/en not_active Expired
- 1972-09-13 PL PL1972157720A patent/PL89701B1/pl unknown
- 1972-09-13 ZA ZA726271A patent/ZA726271B/en unknown
- 1972-09-13 ES ES406622A patent/ES406622A1/en not_active Expired
- 1972-09-13 PL PL1972182587A patent/PL93690B1/pl unknown
- 1972-09-13 PL PL1972182585A patent/PL93588B1/pl unknown
- 1972-09-13 JP JP47091344A patent/JPS4836169A/ja active Pending
- 1972-09-13 PL PL1972182586A patent/PL93669B1/pl unknown
- 1972-09-13 IE IE1249/72A patent/IE36698B1/en unknown
- 1972-09-13 CA CA151,607A patent/CA1007638A/en not_active Expired
- 1972-09-13 AU AU46604/72A patent/AU464649B2/en not_active Expired
- 1972-09-13 NL NL7212419A patent/NL7212419A/xx not_active Application Discontinuation
- 1972-09-13 HU HU72BA2802A patent/HU167410B/en unknown
- 1972-09-13 SE SE7211813A patent/SE412756B/en unknown
- 1972-09-13 JP JP47091343A patent/JPS4836168A/ja active Pending
- 1972-09-14 FR FR7232634A patent/FR2154512B1/fr not_active Expired
- 1972-09-14 AT AT789772A patent/AT322548B/en not_active IP Right Cessation
- 1972-09-14 US US289092A patent/US3860590A/en not_active Expired - Lifetime
-
1975
- 1975-04-01 ES ES436202A patent/ES436202A1/en not_active Expired
- 1975-04-01 ES ES436201A patent/ES436201A1/en not_active Expired
- 1975-04-01 ES ES436200A patent/ES436200A1/en not_active Expired
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