IE36211B1 - Penicillins - Google Patents

Penicillins

Info

Publication number
IE36211B1
IE36211B1 IE371/72A IE37172A IE36211B1 IE 36211 B1 IE36211 B1 IE 36211B1 IE 371/72 A IE371/72 A IE 371/72A IE 37172 A IE37172 A IE 37172A IE 36211 B1 IE36211 B1 IE 36211B1
Authority
IE
Ireland
Prior art keywords
amino
acid
carbamido
group
formula
Prior art date
Application number
IE371/72A
Other versions
IE36211L (en
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of IE36211L publication Critical patent/IE36211L/en
Publication of IE36211B1 publication Critical patent/IE36211B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

1315630 Penicillins BEECHAM GROUP Ltd 21 March 1972 [31 March 1971] 8754/71 Heading C2A The invention comprises a penicillin of Formula II or a salt or an ester thereof, wherein X represents [-O-], [-S-], a grouping of Formula III or wherein R is hydrogen, alkyl or aralkyl and a and b are each integers such that a + b = 4. Such penicillins include 6-[4-amino-1-thiacyclohexan - 4 - yl - carbamido] - penicillanic acid, 6 - [4 - aminotetrahydropyran - 4 - yl - carbamido]-pencillanic acid, 6-[3-amino-1-thiacyclohexan-3-yl-carbamido penicillanic acid, 6-[4- amino - 1,1 - dioxo - 1 - thiacyclohexan - 4 - ylcarbamido] - penicillanic acid, 6 - [4 - amino - 1- benzylpiperid-4-yl-carbamido]-penicillanic acid and salts and esters thereof. A process for the preparation of compounds of Formula II comprises reacting 6-aminopenicillanic acid or a salt or ester thereof, or silyl 6-amino penicillanic acid with a reactive N-acylating derivative of an acid of Formula IV wherein X, a and b are as previously defined and Y is a nitrogen-containing group which may be converted into a primary amino group, and subsequently converting the group Y into a primary amino group. [GB1315630A]
IE371/72A 1971-03-31 1972-03-22 Penicillins IE36211B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB875471 1971-03-31

Publications (2)

Publication Number Publication Date
IE36211L IE36211L (en) 1972-09-30
IE36211B1 true IE36211B1 (en) 1976-09-15

Family

ID=9858638

Family Applications (1)

Application Number Title Priority Date Filing Date
IE371/72A IE36211B1 (en) 1971-03-31 1972-03-22 Penicillins

Country Status (13)

Country Link
AT (1) AT312804B (en)
BE (1) BE781503A (en)
CA (1) CA985274A (en)
CH (1) CH578005A5 (en)
DE (1) DE2215721A1 (en)
DK (1) DK139583B (en)
ES (1) ES401264A1 (en)
FR (1) FR2132170B1 (en)
GB (1) GB1315630A (en)
IE (1) IE36211B1 (en)
IL (1) IL39071A0 (en)
NL (1) NL7204201A (en)
ZA (1) ZA722023B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320135A (en) 1980-05-19 1982-03-16 Sandoz, Inc. Inhibiting growth hormone secretion with 5,5-substituted hydantoin derivatives
FR2772762B1 (en) * 1997-12-18 2000-05-26 Seranalis PROCESSES FOR THE PREPARATION OF A 5-SUBSTITUTED HYDANTOIN DERIVATIVE, AN ALKALINE SALT OF ALPHA-AMINO ACID FROM THIS HYDANTOIN DERIVATIVE, ESTERIFICATION OF CYCLIC ALPHA-AMINO ACIDS, AND NEW ALPHA ACIDS -AMINES
CN1898229B (en) * 2003-12-19 2012-05-30 宇部兴产株式会社 Processes for producing tetrahydropyran-4-one and pyran-4-one

Also Published As

Publication number Publication date
FR2132170A1 (en) 1972-11-17
DK139583B (en) 1979-03-12
IE36211L (en) 1972-09-30
DK139583C (en) 1979-08-27
GB1315630A (en) 1973-05-02
ZA722023B (en) 1972-12-27
FR2132170B1 (en) 1976-04-16
IL39071A0 (en) 1972-05-30
CH578005A5 (en) 1976-07-30
AT312804B (en) 1974-01-25
DE2215721A1 (en) 1972-10-05
ES401264A1 (en) 1975-02-16
NL7204201A (en) 1972-10-03
CA985274A (en) 1976-03-09
BE781503A (en) 1972-10-02

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