IE36107B1 - Indole derivatives and compositions containing the same - Google Patents
Indole derivatives and compositions containing the sameInfo
- Publication number
- IE36107B1 IE36107B1 IE1465/71A IE146571A IE36107B1 IE 36107 B1 IE36107 B1 IE 36107B1 IE 1465/71 A IE1465/71 A IE 1465/71A IE 146571 A IE146571 A IE 146571A IE 36107 B1 IE36107 B1 IE 36107B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- oxide
- pyridyl
- reacting
- hydrolysing
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000001204 N-oxides Chemical class 0.000 abstract 4
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- 150000002466 imines Chemical class 0.000 abstract 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 2
- TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Natural products OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 2
- BZFGKBQHQJVAHS-UHFFFAOYSA-N 2-(trifluoromethyl)pyridine-4-carboxylic acid Chemical compound OC(=O)C1=CC=NC(C(F)(F)F)=C1 BZFGKBQHQJVAHS-UHFFFAOYSA-N 0.000 abstract 1
- FFNVQNRYTPFDDP-UHFFFAOYSA-N 2-cyanopyridine Chemical compound N#CC1=CC=CC=N1 FFNVQNRYTPFDDP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- GZPHSAQLYPIAIN-UHFFFAOYSA-N 3-pyridinecarbonitrile Chemical compound N#CC1=CC=CN=C1 GZPHSAQLYPIAIN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- -1 4-pyridinecarboxylic acid halide Chemical class 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 150000004658 ketimines Chemical class 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- GPHQHTOMRSGBNZ-UHFFFAOYSA-N pyridine-4-carbonitrile Chemical compound N#CC1=CC=NC=C1 GPHQHTOMRSGBNZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5854370 | 1970-12-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36107L IE36107L (en) | 1972-06-09 |
| IE36107B1 true IE36107B1 (en) | 1976-08-18 |
Family
ID=10481862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1465/71A IE36107B1 (en) | 1970-12-09 | 1971-11-19 | Indole derivatives and compositions containing the same |
Country Status (19)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59145847U (ja) * | 1983-03-18 | 1984-09-29 | 三菱自動車工業株式会社 | リクライニングアジヤスタ取付ブラケツト |
| CN108239083B (zh) * | 2016-12-26 | 2021-08-17 | 阿里根公司 | 芳香烃受体调节剂 |
| EP3713937A2 (en) | 2017-11-20 | 2020-09-30 | Ariagen, Inc. | Indole compounds as aryl hydrocarbon receptor (ahr) modulators |
| WO2020214740A1 (en) | 2019-04-15 | 2020-10-22 | Ariagen, Inc. | Chiral indole compounds and their use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1068259B (enrdf_load_stackoverflow) * | 1954-04-28 | 1959-11-05 | ||
| US3517020A (en) * | 1967-11-01 | 1970-06-23 | Sandoz Ag | Certain 1-(3'-nicotinoyl)-2-loweralkylthio-benzimidazoles |
| US3557142A (en) * | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
-
1970
- 1970-12-09 GB GB5854370A patent/GB1318300A/en not_active Expired
-
1971
- 1971-11-18 BE BE775487A patent/BE775487A/xx not_active IP Right Cessation
- 1971-11-19 IE IE1465/71A patent/IE36107B1/xx unknown
- 1971-11-22 ZA ZA717857A patent/ZA717857B/xx unknown
- 1971-11-24 FR FR7142006A patent/FR2117878B1/fr not_active Expired
- 1971-11-24 SE SE7115067A patent/SE390305B/xx unknown
- 1971-11-25 YU YU2981/71A patent/YU34519B/xx unknown
- 1971-11-26 AU AU36229/71A patent/AU452586B2/en not_active Expired
- 1971-11-29 CH CH1734771A patent/CH532596A/fr not_active IP Right Cessation
- 1971-11-29 NL NL717116360A patent/NL153774B/xx not_active IP Right Cessation
- 1971-12-08 DK DK601371AA patent/DK136367B/da not_active IP Right Cessation
- 1971-12-08 NO NO4526/71A patent/NO137549C/no unknown
- 1971-12-08 CA CA129,677A patent/CA956638A/en not_active Expired
- 1971-12-09 OA OA54437A patent/OA03929A/xx unknown
- 1971-12-09 JP JP46100058A patent/JPS5133910B1/ja active Pending
- 1971-12-09 HU HULA785A patent/HU166730B/hu unknown
- 1971-12-09 ES ES397787A patent/ES397787A1/es not_active Expired
- 1971-12-09 AT AT1061171A patent/AT312594B/de not_active IP Right Cessation
- 1971-12-09 FI FI3512/71A patent/FI55509C/fi active
- 1971-12-09 AT AT173173A patent/AT319229B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2160017B2 (de) | 1976-02-19 |
| YU298171A (en) | 1979-02-28 |
| BE775487A (fr) | 1972-05-18 |
| DE2160017A1 (de) | 1972-06-22 |
| IE36107L (en) | 1972-06-09 |
| AT319229B (de) | 1974-12-10 |
| AT312594B (de) | 1974-01-10 |
| NL7116360A (enrdf_load_stackoverflow) | 1972-06-13 |
| CA956638A (en) | 1974-10-22 |
| CH532596A (fr) | 1973-01-15 |
| ZA717857B (en) | 1972-08-30 |
| SE390305B (sv) | 1976-12-13 |
| FI55509B (fi) | 1979-04-30 |
| FR2117878B1 (enrdf_load_stackoverflow) | 1974-10-18 |
| FR2117878A1 (enrdf_load_stackoverflow) | 1972-07-28 |
| AU452586B2 (en) | 1974-09-05 |
| OA03929A (fr) | 1975-08-14 |
| NO137549C (no) | 1978-03-15 |
| NO137549B (no) | 1977-12-05 |
| DK136367C (enrdf_load_stackoverflow) | 1978-02-27 |
| YU34519B (en) | 1979-09-10 |
| HU166730B (enrdf_load_stackoverflow) | 1975-05-28 |
| FI55509C (fi) | 1979-08-10 |
| GB1318300A (en) | 1973-05-23 |
| JPS5133910B1 (enrdf_load_stackoverflow) | 1976-09-22 |
| AU3622971A (en) | 1973-05-31 |
| NL153774B (nl) | 1977-07-15 |
| ES397787A1 (es) | 1975-04-16 |
| DK136367B (da) | 1977-10-03 |
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