IE35794B1 - Ergolene derivatives - Google Patents
Ergolene derivativesInfo
- Publication number
- IE35794B1 IE35794B1 IE1406/71A IE140671A IE35794B1 IE 35794 B1 IE35794 B1 IE 35794B1 IE 1406/71 A IE1406/71 A IE 1406/71A IE 140671 A IE140671 A IE 140671A IE 35794 B1 IE35794 B1 IE 35794B1
- Authority
- IE
- Ireland
- Prior art keywords
- nov
- alkyl
- ergolene derivatives
- ergolene
- derivatives
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- AWFDCTXCTHGORH-HGHGUNKESA-N 6-[4-[(6ar,9r,10ar)-5-bromo-7-methyl-6,6a,8,9,10,10a-hexahydro-4h-indolo[4,3-fg]quinoline-9-carbonyl]piperazin-1-yl]-1-methylpyridin-2-one Chemical class O=C([C@H]1CN([C@H]2[C@@H](C=3C=CC=C4NC(Br)=C(C=34)C2)C1)C)N(CC1)CCN1C1=CC=CC(=O)N1C AWFDCTXCTHGORH-HGHGUNKESA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/02—Ergot alkaloids of the cyclic peptide type
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT5466070 | 1970-11-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35794L IE35794L (en) | 1972-05-12 |
| IE35794B1 true IE35794B1 (en) | 1976-05-26 |
Family
ID=11287460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1406/71A IE35794B1 (en) | 1970-11-12 | 1971-11-08 | Ergolene derivatives |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US3814765A (h) |
| JP (1) | JPS5344478B1 (h) |
| AT (1) | AT310953B (h) |
| AU (1) | AU466630B2 (h) |
| BE (1) | BE775145A (h) |
| CA (1) | CA926864A (h) |
| CH (1) | CH561721A5 (h) |
| CS (1) | CS165363B2 (h) |
| DE (1) | DE2155578C3 (h) |
| DK (1) | DK140842B (h) |
| FR (1) | FR2114476A5 (h) |
| GB (1) | GB1315439A (h) |
| HU (1) | HU164041B (h) |
| IE (1) | IE35794B1 (h) |
| IL (1) | IL38096A (h) |
| NL (1) | NL155016B (h) |
| NO (1) | NO128533B (h) |
| SE (1) | SE385707B (h) |
| SU (1) | SU406355A3 (h) |
| ZA (1) | ZA717541B (h) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001242A (en) * | 1974-08-02 | 1977-01-04 | Eli Lilly And Company | D-6-methyl-8-formyl-10α-alkoxy-8-ergolene |
| US3929796A (en) * | 1974-08-02 | 1975-12-30 | Lilly Co Eli | Synthesis of penniclavine and elymoclavine |
| US3923812A (en) * | 1974-08-02 | 1975-12-02 | Lilly Co Eli | Synthesis of elymoclavine |
| US4054567A (en) * | 1975-08-11 | 1977-10-18 | Eli Lilly And Company | 6-Methyl-8β-hydroxymethyl-8-γ-substituted-9-ergolene compounds |
| US4082753A (en) * | 1976-02-17 | 1978-04-04 | Eli Lilly And Company | Penniclavine acetonide |
| US8710092B2 (en) * | 2009-12-23 | 2014-04-29 | Map Pharmaceuticals, Inc. | Substituted indolo 4,3 FG quinolines useful for treating migraine |
| CN103827113A (zh) | 2011-06-23 | 2014-05-28 | Map药物公司 | 新型氟麦角碱类似物 |
| SG11201403434YA (en) | 2011-12-19 | 2014-09-26 | Map Pharmaceuticals Inc | Novel iso-ergoline derivatives |
| SG11201403433PA (en) | 2011-12-21 | 2014-07-30 | Map Pharmaceuticals Inc | Novel neuromodulatory compounds |
| US9012640B2 (en) | 2012-06-22 | 2015-04-21 | Map Pharmaceuticals, Inc. | Cabergoline derivatives |
-
1971
- 1971-10-04 US US00186385A patent/US3814765A/en not_active Expired - Lifetime
- 1971-11-01 AU AU35198/71A patent/AU466630B2/en not_active Expired
- 1971-11-01 NL NL717115017A patent/NL155016B/xx unknown
- 1971-11-08 FR FR7139938A patent/FR2114476A5/fr not_active Expired
- 1971-11-08 GB GB5177271A patent/GB1315439A/en not_active Expired
- 1971-11-08 CA CA127063A patent/CA926864A/en not_active Expired
- 1971-11-08 IL IL38096A patent/IL38096A/en unknown
- 1971-11-08 CS CS7815A patent/CS165363B2/cs unknown
- 1971-11-08 NO NO04110/71*[A patent/NO128533B/no unknown
- 1971-11-08 IE IE1406/71A patent/IE35794B1/xx unknown
- 1971-11-09 JP JP8876871A patent/JPS5344478B1/ja active Pending
- 1971-11-09 SU SU1711760A patent/SU406355A3/ru active
- 1971-11-09 SE SE7114282A patent/SE385707B/xx unknown
- 1971-11-09 ZA ZA717541A patent/ZA717541B/xx unknown
- 1971-11-09 DE DE2155578A patent/DE2155578C3/de not_active Expired
- 1971-11-09 DK DK547271AA patent/DK140842B/da unknown
- 1971-11-10 AT AT971071A patent/AT310953B/de not_active IP Right Cessation
- 1971-11-10 BE BE775145A patent/BE775145A/xx unknown
- 1971-11-11 HU HUFA898A patent/HU164041B/hu unknown
- 1971-11-11 CH CH1641871A patent/CH561721A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL155016B (nl) | 1977-11-15 |
| DK140842B (da) | 1979-11-26 |
| CH561721A5 (h) | 1975-05-15 |
| IE35794L (en) | 1972-05-12 |
| NL7115017A (h) | 1972-05-16 |
| IL38096A (en) | 1976-02-29 |
| CA926864A (en) | 1973-05-22 |
| IL38096A0 (en) | 1972-01-27 |
| ZA717541B (en) | 1972-08-30 |
| AU466630B2 (en) | 1975-11-06 |
| AU3519871A (en) | 1973-05-10 |
| BE775145A (fr) | 1972-05-10 |
| CS165363B2 (h) | 1975-12-22 |
| FR2114476A5 (h) | 1972-06-30 |
| NO128533B (h) | 1973-12-03 |
| SE385707B (sv) | 1976-07-19 |
| DE2155578A1 (de) | 1972-05-18 |
| DE2155578C3 (de) | 1979-01-04 |
| DK140842C (h) | 1980-05-05 |
| JPS5344478B1 (h) | 1978-11-29 |
| GB1315439A (en) | 1973-05-02 |
| DE2155578B2 (de) | 1978-05-03 |
| US3814765A (en) | 1974-06-04 |
| AT310953B (de) | 1973-10-25 |
| HU164041B (h) | 1973-12-28 |
| SU406355A3 (h) | 1973-11-05 |
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