IE33283L - N-arallyl-n'aralkyl piperazines - Google Patents
N-arallyl-n'aralkyl piperazinesInfo
- Publication number
- IE33283L IE33283L IE690783A IE78369A IE33283L IE 33283 L IE33283 L IE 33283L IE 690783 A IE690783 A IE 690783A IE 78369 A IE78369 A IE 78369A IE 33283 L IE33283 L IE 33283L
- Authority
- IE
- Ireland
- Prior art keywords
- fluoro
- piperazine
- compound
- cinnamyl
- hcl
- Prior art date
Links
- -1 aralkyl piperazines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000001207 fluorophenyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- AVLSENGQODSCBK-UHFFFAOYSA-N 1-(3-chloroprop-1-enyl)-4-fluorobenzene Chemical compound FC1=CC=C(C=CCCl)C=C1 AVLSENGQODSCBK-UHFFFAOYSA-N 0.000 abstract 1
- GNFODANOHXAUPE-UHFFFAOYSA-N 1-[chloro(phenyl)methyl]-4-fluorobenzene Chemical compound C1=CC(F)=CC=C1C(Cl)C1=CC=CC=C1 GNFODANOHXAUPE-UHFFFAOYSA-N 0.000 abstract 1
- FHPNLCLHMNPLEW-UHFFFAOYSA-N 1-[chloro-(4-fluorophenyl)methyl]-4-fluorobenzene Chemical compound C1=CC(F)=CC=C1C(Cl)C1=CC=C(F)C=C1 FHPNLCLHMNPLEW-UHFFFAOYSA-N 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,268,710. Fluoro-substituted N-cinnamyl-N<SP>1</SP>- benzhydryl piperazine. JANSSEN PHARMACEUTICA N.V. 10 June 1969 [2 July, 1968], No. 29382/69. Heading C2C. Novel fluoro-substituted N-cinnamyl-N<SP>1</SP>- benzhydryl piperazines of the formula wherein each Ar may be a phenyl or fluorophenyl group, provided that at least one Ar is a fluorophenyl group, may be obtained by reacting a compound with a compound Y-CH 2 -CH=CH-Ar, where Y and Y<SP>1</SP> are different and represent a halogen atom or a piperazine residue, in the presence of a base and, if desired, forming a therapeutically active acid addition salt. Preparation of the following intermediates is also described: 1-(p-fluoro-α.-phenylbenzyl)-piperazine from p-fluoro-α-phenylbenzylchloride and piperazine; p-fluorocinnamylchloride from pfluoro-α-vinylbenzyl alcohol and HCl; di-(4- fluorophenyl)-chloromethane from α-(4-fluoro-phenyl)-4-fluorobenzyl alcohol and HCl. Pharmaceutical composition having anti-arrhythmic activity comprises a compound of Formula I above, or a therapeutically active acid addition salt thereof, in admixture with a pharmaceutically acceptable carrier, in forms suitable for oral or parenteral administration.
[GB1268710A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74199968A | 1968-07-02 | 1968-07-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33283L true IE33283L (en) | 1970-01-02 |
| IE33283B1 IE33283B1 (en) | 1974-05-15 |
Family
ID=24983099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE783/69A IE33283B1 (en) | 1968-07-02 | 1969-06-09 | N-arallyl-n'-aralkyl piperazines and pharmaceutical compositions thereof |
Country Status (20)
| Country | Link |
|---|---|
| AT (1) | AT289811B (en) |
| BE (1) | BE735452A (en) |
| BR (1) | BR6910304D0 (en) |
| CH (1) | CH510677A (en) |
| DE (1) | DE1929330C3 (en) |
| DK (1) | DK121175B (en) |
| ES (1) | ES368981A1 (en) |
| FI (1) | FI52979C (en) |
| FR (1) | FR2014487A1 (en) |
| GB (1) | GB1268710A (en) |
| IE (1) | IE33283B1 (en) |
| IL (1) | IL32520A (en) |
| LU (1) | LU58970A1 (en) |
| NL (1) | NL162646C (en) |
| NO (1) | NO124776B (en) |
| PL (1) | PL80098B1 (en) |
| SE (1) | SE350972B (en) |
| SU (1) | SU403182A3 (en) |
| YU (1) | YU36715B (en) |
| ZA (1) | ZA694714B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1213131B (en) * | 1984-02-02 | 1989-12-14 | Yason Srl | COMPOUND FOR PERIPHERAL ANTAGONIST, ANTICONVULSIVE AND EUMETABOLIC BRAIN ACTIVITY, METHOD FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS. |
-
1969
- 1969-06-09 IE IE783/69A patent/IE33283B1/en unknown
- 1969-06-10 DE DE1929330A patent/DE1929330C3/en not_active Expired
- 1969-06-10 GB GB29382/69A patent/GB1268710A/en not_active Expired
- 1969-06-13 CH CH911169A patent/CH510677A/en not_active IP Right Cessation
- 1969-06-26 AT AT610669A patent/AT289811B/en not_active IP Right Cessation
- 1969-06-26 SU SU1341578A patent/SU403182A3/ru active
- 1969-06-27 FR FR6921783A patent/FR2014487A1/fr active Pending
- 1969-06-27 LU LU58970D patent/LU58970A1/xx unknown
- 1969-06-30 NL NL6910007.A patent/NL162646C/en not_active IP Right Cessation
- 1969-06-30 BR BR210304/69A patent/BR6910304D0/en unknown
- 1969-06-30 ES ES368981A patent/ES368981A1/en not_active Expired
- 1969-06-30 SE SE09260/69*A patent/SE350972B/xx unknown
- 1969-06-30 YU YU1662/69A patent/YU36715B/en unknown
- 1969-07-01 NO NO2753/69A patent/NO124776B/no unknown
- 1969-07-01 PL PL1969134557A patent/PL80098B1/pl unknown
- 1969-07-01 BE BE735452D patent/BE735452A/xx not_active IP Right Cessation
- 1969-07-01 IL IL32520A patent/IL32520A/en unknown
- 1969-07-01 FI FI1956/69A patent/FI52979C/fi active
- 1969-07-02 ZA ZA694714A patent/ZA694714B/en unknown
- 1969-07-02 DK DK357369AA patent/DK121175B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SU403182A3 (en) | 1973-10-19 |
| IL32520A (en) | 1972-09-28 |
| NL6910007A (en) | 1970-01-06 |
| FI52979C (en) | 1978-01-10 |
| SE350972B (en) | 1972-11-13 |
| DE1929330C3 (en) | 1979-09-13 |
| NL162646C (en) | 1980-06-16 |
| BE735452A (en) | 1970-01-02 |
| DK121175B (en) | 1971-09-20 |
| PL80098B1 (en) | 1975-08-30 |
| NO124776B (en) | 1972-06-05 |
| DE1929330B2 (en) | 1979-01-18 |
| ES368981A1 (en) | 1971-05-16 |
| FI52979B (en) | 1977-09-30 |
| ZA694714B (en) | 1971-02-24 |
| DE1929330A1 (en) | 1970-02-12 |
| FR2014487A1 (en) | 1970-04-17 |
| AT289811B (en) | 1971-05-10 |
| YU166269A (en) | 1982-02-25 |
| LU58970A1 (en) | 1969-11-12 |
| BR6910304D0 (en) | 1973-04-19 |
| GB1268710A (en) | 1972-03-29 |
| YU36715B (en) | 1984-08-31 |
| CH510677A (en) | 1971-07-31 |
| IL32520A0 (en) | 1969-09-25 |
| IE33283B1 (en) | 1974-05-15 |
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