IE33283L - N-arallyl-n'aralkyl piperazines - Google Patents

N-arallyl-n'aralkyl piperazines

Info

Publication number
IE33283L
IE33283L IE690783A IE78369A IE33283L IE 33283 L IE33283 L IE 33283L IE 690783 A IE690783 A IE 690783A IE 78369 A IE78369 A IE 78369A IE 33283 L IE33283 L IE 33283L
Authority
IE
Ireland
Prior art keywords
fluoro
piperazine
compound
cinnamyl
hcl
Prior art date
Application number
IE690783A
Other versions
IE33283B1 (en
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IE33283L publication Critical patent/IE33283L/en
Publication of IE33283B1 publication Critical patent/IE33283B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,268,710. Fluoro-substituted N-cinnamyl-N<SP>1</SP>- benzhydryl piperazine. JANSSEN PHARMACEUTICA N.V. 10 June 1969 [2 July, 1968], No. 29382/69. Heading C2C. Novel fluoro-substituted N-cinnamyl-N<SP>1</SP>- benzhydryl piperazines of the formula wherein each Ar may be a phenyl or fluorophenyl group, provided that at least one Ar is a fluorophenyl group, may be obtained by reacting a compound with a compound Y-CH 2 -CH=CH-Ar, where Y and Y<SP>1</SP> are different and represent a halogen atom or a piperazine residue, in the presence of a base and, if desired, forming a therapeutically active acid addition salt. Preparation of the following intermediates is also described: 1-(p-fluoro-α.-phenylbenzyl)-piperazine from p-fluoro-α-phenylbenzylchloride and piperazine; p-fluorocinnamylchloride from pfluoro-α-vinylbenzyl alcohol and HCl; di-(4- fluorophenyl)-chloromethane from α-(4-fluoro-phenyl)-4-fluorobenzyl alcohol and HCl. Pharmaceutical composition having anti-arrhythmic activity comprises a compound of Formula I above, or a therapeutically active acid addition salt thereof, in admixture with a pharmaceutically acceptable carrier, in forms suitable for oral or parenteral administration. [GB1268710A]
IE783/69A 1968-07-02 1969-06-09 N-arallyl-n'-aralkyl piperazines and pharmaceutical compositions thereof IE33283B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74199968A 1968-07-02 1968-07-02

Publications (2)

Publication Number Publication Date
IE33283L true IE33283L (en) 1970-01-02
IE33283B1 IE33283B1 (en) 1974-05-15

Family

ID=24983099

Family Applications (1)

Application Number Title Priority Date Filing Date
IE783/69A IE33283B1 (en) 1968-07-02 1969-06-09 N-arallyl-n'-aralkyl piperazines and pharmaceutical compositions thereof

Country Status (20)

Country Link
AT (1) AT289811B (en)
BE (1) BE735452A (en)
BR (1) BR6910304D0 (en)
CH (1) CH510677A (en)
DE (1) DE1929330C3 (en)
DK (1) DK121175B (en)
ES (1) ES368981A1 (en)
FI (1) FI52979C (en)
FR (1) FR2014487A1 (en)
GB (1) GB1268710A (en)
IE (1) IE33283B1 (en)
IL (1) IL32520A (en)
LU (1) LU58970A1 (en)
NL (1) NL162646C (en)
NO (1) NO124776B (en)
PL (1) PL80098B1 (en)
SE (1) SE350972B (en)
SU (1) SU403182A3 (en)
YU (1) YU36715B (en)
ZA (1) ZA694714B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213131B (en) * 1984-02-02 1989-12-14 Yason Srl COMPOUND FOR PERIPHERAL ANTAGONIST, ANTICONVULSIVE AND EUMETABOLIC BRAIN ACTIVITY, METHOD FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS.

Also Published As

Publication number Publication date
ES368981A1 (en) 1971-05-16
FI52979B (en) 1977-09-30
SU403182A3 (en) 1973-10-19
YU166269A (en) 1982-02-25
LU58970A1 (en) 1969-11-12
DE1929330A1 (en) 1970-02-12
IL32520A0 (en) 1969-09-25
NL162646C (en) 1980-06-16
AT289811B (en) 1971-05-10
IE33283B1 (en) 1974-05-15
DE1929330C3 (en) 1979-09-13
ZA694714B (en) 1971-02-24
DE1929330B2 (en) 1979-01-18
GB1268710A (en) 1972-03-29
DK121175B (en) 1971-09-20
SE350972B (en) 1972-11-13
FR2014487A1 (en) 1970-04-17
BE735452A (en) 1970-01-02
PL80098B1 (en) 1975-08-30
NO124776B (en) 1972-06-05
YU36715B (en) 1984-08-31
FI52979C (en) 1978-01-10
NL6910007A (en) 1970-01-06
IL32520A (en) 1972-09-28
CH510677A (en) 1971-07-31
BR6910304D0 (en) 1973-04-19

Similar Documents

Publication Publication Date Title
GB1457873A (en) Imidazotriazines
GB1181034A (en) Pyrazinamidoguanidines and their preparation
IE33283L (en) N-arallyl-n&#39;aralkyl piperazines
GB1342828A (en) Pyrimidinyl-piperazines and processes for their preparation
GB1322451A (en) 3-amino-5-benzyl-1,2,4-oxadiazoles
MY106235A (en) New 2 - carbonyl substituted n, n&#39;&#39; -di (trimethoxybenzoyl) piperazines, process for preparing the same and therapeutical compounds containing them.
GB1156781A (en) New Heterocyclic Compounds
GB1314899A (en) Thiosemicarbazones processes for their preparations and compositions incorporating them
GB1514225A (en) Paracetamol derivatives
GB1221407A (en) 0,2,3,4-tetrahydro-7-substituted-6-sulfamyl-4-quinazolinones, process for preparing the same and pharmaceutical compositions comprising the same
GR860045B (en) Novel piperazine derivatives processes for production thereof and pharmaceutical compositions comprising said compounds as active ingredient
GB1315355A (en) Benzotriazole derivatives
GB1377610A (en) 5-piperidine-4-spiro- oxazolidinones method for their preparation and applications thereof
GB1384523A (en) Oxime derivatives and their preparation
IE37288B1 (en) Pharmaceutical compositions for use in the treatment of certain respiratory diseases or conditions in prematurely born children
GB1223062A (en) Improvements in or relating to new aminoacid derivatives
GB1193438A (en) Barbituric Acid Derivatives, preparation thereof and Pharmaceutical Compositions containing them
GB1159271A (en) 1,5-Disubstituted Barbituric Acid Derivatives and process for the manufacture thereof
GB1259400A (en)
GB1318643A (en) Syndonimine derivatives the preparation thereof and compositions containing the same
IE34313B1 (en) 2-hydroxy-5-amino-benzamide derivatives
GB1530931A (en) N-(1-(4-phenyl-4-oxobutyl)-4-piperidyl)-2-thiophene carboxamide
GB1110858A (en) Improvements in and relating to new sulphonamides,the process of preparation and theapplications thereof
GB1174874A (en) Derivatives of Quinoxaline-di-N-Oxide
GB1316702A (en) Substituted piperazine derivatives