GB1268710A - N-arallyl-n'-aralkyl piperazines and pharmaceutical compositions thereof - Google Patents
N-arallyl-n'-aralkyl piperazines and pharmaceutical compositions thereofInfo
- Publication number
- GB1268710A GB1268710A GB29382/69A GB2938269A GB1268710A GB 1268710 A GB1268710 A GB 1268710A GB 29382/69 A GB29382/69 A GB 29382/69A GB 2938269 A GB2938269 A GB 2938269A GB 1268710 A GB1268710 A GB 1268710A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fluoro
- piperazine
- compound
- piperazines
- cinnamyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,268,710. Fluoro-substituted N-cinnamyl-N<SP>1</SP>- benzhydryl piperazine. JANSSEN PHARMACEUTICA N.V. 10 June 1969 [2 July, 1968], No. 29382/69. Heading C2C. Novel fluoro-substituted N-cinnamyl-N<SP>1</SP>- benzhydryl piperazines of the formula wherein each Ar may be a phenyl or fluorophenyl group, provided that at least one Ar is a fluorophenyl group, may be obtained by reacting a compound with a compound Y-CH 2 -CH=CH-Ar, where Y and Y<SP>1</SP> are different and represent a halogen atom or a piperazine residue, in the presence of a base and, if desired, forming a therapeutically active acid addition salt. Preparation of the following intermediates is also described: 1-(p-fluoro-α.-phenylbenzyl)-piperazine from p-fluoro-α-phenylbenzylchloride and piperazine; p-fluorocinnamylchloride from pfluoro-α-vinylbenzyl alcohol and HCl; di-(4- fluorophenyl)-chloromethane from α-(4-fluoro-phenyl)-4-fluorobenzyl alcohol and HCl. Pharmaceutical composition having anti-arrhythmic activity comprises a compound of Formula I above, or a therapeutically active acid addition salt thereof, in admixture with a pharmaceutically acceptable carrier, in forms suitable for oral or parenteral administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74199968A | 1968-07-02 | 1968-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1268710A true GB1268710A (en) | 1972-03-29 |
Family
ID=24983099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB29382/69A Expired GB1268710A (en) | 1968-07-02 | 1969-06-10 | N-arallyl-n'-aralkyl piperazines and pharmaceutical compositions thereof |
Country Status (20)
| Country | Link |
|---|---|
| AT (1) | AT289811B (en) |
| BE (1) | BE735452A (en) |
| BR (1) | BR6910304D0 (en) |
| CH (1) | CH510677A (en) |
| DE (1) | DE1929330C3 (en) |
| DK (1) | DK121175B (en) |
| ES (1) | ES368981A1 (en) |
| FI (1) | FI52979C (en) |
| FR (1) | FR2014487A1 (en) |
| GB (1) | GB1268710A (en) |
| IE (1) | IE33283B1 (en) |
| IL (1) | IL32520A (en) |
| LU (1) | LU58970A1 (en) |
| NL (1) | NL162646C (en) |
| NO (1) | NO124776B (en) |
| PL (1) | PL80098B1 (en) |
| SE (1) | SE350972B (en) |
| SU (1) | SU403182A3 (en) |
| YU (1) | YU36715B (en) |
| ZA (1) | ZA694714B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0152799A1 (en) * | 1984-02-02 | 1985-08-28 | PULITZER ITALIANA S.p.A. | Compounds having peripheral calcium antagonist, anticonvulsive and eumetabolic activity, processes for the preparation thereof and pharmaceutical compositions containing them |
-
1969
- 1969-06-09 IE IE783/69A patent/IE33283B1/en unknown
- 1969-06-10 GB GB29382/69A patent/GB1268710A/en not_active Expired
- 1969-06-10 DE DE1929330A patent/DE1929330C3/en not_active Expired
- 1969-06-13 CH CH911169A patent/CH510677A/en not_active IP Right Cessation
- 1969-06-26 AT AT610669A patent/AT289811B/en not_active IP Right Cessation
- 1969-06-26 SU SU1341578A patent/SU403182A3/ru active
- 1969-06-27 LU LU58970D patent/LU58970A1/xx unknown
- 1969-06-27 FR FR6921783A patent/FR2014487A1/fr active Pending
- 1969-06-30 YU YU1662/69A patent/YU36715B/en unknown
- 1969-06-30 NL NL6910007.A patent/NL162646C/en not_active IP Right Cessation
- 1969-06-30 ES ES368981A patent/ES368981A1/en not_active Expired
- 1969-06-30 BR BR210304/69A patent/BR6910304D0/en unknown
- 1969-06-30 SE SE09260/69*A patent/SE350972B/xx unknown
- 1969-07-01 NO NO2753/69A patent/NO124776B/no unknown
- 1969-07-01 BE BE735452D patent/BE735452A/xx not_active IP Right Cessation
- 1969-07-01 PL PL1969134557A patent/PL80098B1/pl unknown
- 1969-07-01 IL IL32520A patent/IL32520A/en unknown
- 1969-07-01 FI FI1956/69A patent/FI52979C/fi active
- 1969-07-02 DK DK357369AA patent/DK121175B/en unknown
- 1969-07-02 ZA ZA694714A patent/ZA694714B/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0152799A1 (en) * | 1984-02-02 | 1985-08-28 | PULITZER ITALIANA S.p.A. | Compounds having peripheral calcium antagonist, anticonvulsive and eumetabolic activity, processes for the preparation thereof and pharmaceutical compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| ES368981A1 (en) | 1971-05-16 |
| FI52979B (en) | 1977-09-30 |
| SU403182A3 (en) | 1973-10-19 |
| YU166269A (en) | 1982-02-25 |
| LU58970A1 (en) | 1969-11-12 |
| DE1929330A1 (en) | 1970-02-12 |
| IL32520A0 (en) | 1969-09-25 |
| NL162646C (en) | 1980-06-16 |
| AT289811B (en) | 1971-05-10 |
| IE33283B1 (en) | 1974-05-15 |
| DE1929330C3 (en) | 1979-09-13 |
| ZA694714B (en) | 1971-02-24 |
| DE1929330B2 (en) | 1979-01-18 |
| IE33283L (en) | 1970-01-02 |
| DK121175B (en) | 1971-09-20 |
| SE350972B (en) | 1972-11-13 |
| FR2014487A1 (en) | 1970-04-17 |
| BE735452A (en) | 1970-01-02 |
| PL80098B1 (en) | 1975-08-30 |
| NO124776B (en) | 1972-06-05 |
| YU36715B (en) | 1984-08-31 |
| FI52979C (en) | 1978-01-10 |
| NL6910007A (en) | 1970-01-06 |
| IL32520A (en) | 1972-09-28 |
| CH510677A (en) | 1971-07-31 |
| BR6910304D0 (en) | 1973-04-19 |
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