IE33186B1 - Quinazoline-thione derivatives - Google Patents
Quinazoline-thione derivativesInfo
- Publication number
- IE33186B1 IE33186B1 IE891/69A IE89169A IE33186B1 IE 33186 B1 IE33186 B1 IE 33186B1 IE 891/69 A IE891/69 A IE 891/69A IE 89169 A IE89169 A IE 89169A IE 33186 B1 IE33186 B1 IE 33186B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- alkoxy
- compounds
- reacting
- prepared
- Prior art date
Links
- MHBPJMUAIOKJNL-UHFFFAOYSA-N 1h-quinazoline-2-thione Chemical class C1=CC=CC2=NC(S)=NC=C21 MHBPJMUAIOKJNL-UHFFFAOYSA-N 0.000 title 1
- 229910052794 bromium Inorganic materials 0.000 abstract 6
- 229910052799 carbon Inorganic materials 0.000 abstract 6
- 229910052801 chlorine Inorganic materials 0.000 abstract 6
- 229910052731 fluorine Inorganic materials 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- -1 dialkylamino compounds Chemical class 0.000 abstract 3
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 abstract 2
- GRHBQAYDJPGGLF-UHFFFAOYSA-N isothiocyanic acid Chemical compound N=C=S GRHBQAYDJPGGLF-UHFFFAOYSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
- IGDKJXXPUDSVMV-UHFFFAOYSA-N 3-methyl-n-propan-2-ylaniline Chemical compound CC(C)NC1=CC=CC(C)=C1 IGDKJXXPUDSVMV-UHFFFAOYSA-N 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- SOIFLUNRINLCBN-UHFFFAOYSA-N ammonium thiocyanate Chemical compound [NH4+].[S-]C#N SOIFLUNRINLCBN-UHFFFAOYSA-N 0.000 abstract 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- CYQAYERJWZKYML-UHFFFAOYSA-N phosphorus pentasulfide Chemical compound S1P(S2)(=S)SP3(=S)SP1(=S)SP2(=S)S3 CYQAYERJWZKYML-UHFFFAOYSA-N 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000007127 saponification reaction Methods 0.000 abstract 1
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 1
- 239000012279 sodium borohydride Substances 0.000 abstract 1
- 150000003585 thioureas Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C07D239/82—Oxygen atoms with an aryl radical attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L13/00—Devices or apparatus for measuring differences of two or more fluid pressure values
- G01L13/02—Devices or apparatus for measuring differences of two or more fluid pressure values using elastically-deformable members or pistons as sensing elements
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Water Treatment By Electricity Or Magnetism (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74180568A | 1968-07-01 | 1968-07-01 | |
| US81638369A | 1969-04-15 | 1969-04-15 | |
| US81947769A | 1969-04-25 | 1969-04-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33186L IE33186L (en) | 1970-01-01 |
| IE33186B1 true IE33186B1 (en) | 1974-04-17 |
Family
ID=27419277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE891/69A IE33186B1 (en) | 1968-07-01 | 1969-06-30 | Quinazoline-thione derivatives |
Country Status (15)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3712892A (en) * | 1969-08-02 | 1973-01-23 | Sumitomo Chemical Co | Quinazolinone derivatives |
| WO2015120059A1 (en) * | 2014-02-04 | 2015-08-13 | Yates Charles Ryan | Inhibitors of paxillin function and related compositions and methods |
-
1969
- 1969-05-26 RO RO62704A patent/RO56665A/ro unknown
- 1969-06-11 CH CH889269A patent/CH514596A/de not_active IP Right Cessation
- 1969-06-13 GB GB1265548D patent/GB1265548A/en not_active Expired
- 1969-06-13 NO NO02447/69A patent/NO128998B/no unknown
- 1969-06-16 DK DK323069AA patent/DK131151B/da unknown
- 1969-06-19 SE SE6908762A patent/SE376421B/xx unknown
- 1969-06-26 DE DE1932401A patent/DE1932401C3/de not_active Expired
- 1969-06-26 NL NL6909804A patent/NL6909804A/xx not_active Application Discontinuation
- 1969-06-27 BE BE735343D patent/BE735343A/xx unknown
- 1969-06-28 BG BG012548A patent/BG16035A3/bg unknown
- 1969-06-29 IL IL32504A patent/IL32504A/en unknown
- 1969-06-30 FR FR6921993A patent/FR2012060A1/fr not_active Withdrawn
- 1969-06-30 IE IE891/69A patent/IE33186B1/xx unknown
- 1969-06-30 CA CA055,705A patent/CA956950A/en not_active Expired
- 1969-06-30 ES ES368945A patent/ES368945A1/es not_active Expired
-
1970
- 1970-05-16 ES ES379709A patent/ES379709A1/es not_active Expired
- 1970-05-16 ES ES379708A patent/ES379708A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES379709A1 (es) | 1973-01-16 |
| DE1932401A1 (de) | 1970-01-08 |
| RO56665A (enrdf_load_stackoverflow) | 1974-06-01 |
| DK131151C (enrdf_load_stackoverflow) | 1975-10-27 |
| GB1265548A (enrdf_load_stackoverflow) | 1972-03-01 |
| FR2012060A1 (enrdf_load_stackoverflow) | 1970-03-13 |
| IE33186L (en) | 1970-01-01 |
| DE1932401B2 (de) | 1979-08-16 |
| NL6909804A (enrdf_load_stackoverflow) | 1970-01-05 |
| ES379708A1 (es) | 1973-02-01 |
| DE1932401C3 (de) | 1980-04-17 |
| DK131151B (da) | 1975-06-02 |
| BG16035A3 (bg) | 1972-05-20 |
| BE735343A (enrdf_load_stackoverflow) | 1969-12-29 |
| IL32504A0 (en) | 1969-08-27 |
| NO128998B (enrdf_load_stackoverflow) | 1974-02-11 |
| ES368945A1 (es) | 1971-07-16 |
| CA956950A (en) | 1974-10-29 |
| CH514596A (de) | 1971-10-31 |
| IL32504A (en) | 1973-06-29 |
| SE376421B (enrdf_load_stackoverflow) | 1975-05-26 |
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