HUT71400A - Biologically active ureido derivatives useful as antimetastatic agents - Google Patents
Biologically active ureido derivatives useful as antimetastatic agents Download PDFInfo
- Publication number
- HUT71400A HUT71400A HU9403177A HU9403177A HUT71400A HU T71400 A HUT71400 A HU T71400A HU 9403177 A HU9403177 A HU 9403177A HU 9403177 A HU9403177 A HU 9403177A HU T71400 A HUT71400 A HU T71400A
- Authority
- HU
- Hungary
- Prior art keywords
- methyl
- bis
- pyrrole
- carbonyl
- imino
- Prior art date
Links
- 239000002257 antimetastatic agent Substances 0.000 title claims description 4
- 125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 title description 3
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- -1 carbonylimino Chemical group 0.000 claims description 24
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 14
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- 230000003472 neutralizing effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
- SSPQHAKUUKFFBB-UHFFFAOYSA-J tetrasodium naphthalene-1,3-disulfonate Chemical compound [Na+].[Na+].[Na+].[Na+].C1(=CC(=CC2=CC=CC=C12)S(=O)(=O)[O-])S(=O)(=O)[O-].C1(=CC(=CC2=CC=CC=C12)S(=O)(=O)[O-])S(=O)(=O)[O-] SSPQHAKUUKFFBB-UHFFFAOYSA-J 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939304589A GB9304589D0 (en) | 1993-03-05 | 1993-03-05 | Biologically active ureido derivatives useful as antimetastic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUT71400A true HUT71400A (en) | 1995-11-28 |
Family
ID=10731580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9403177A HUT71400A (en) | 1993-03-05 | 1994-01-31 | Biologically active ureido derivatives useful as antimetastatic agents |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5534539A (en, 2012) |
| EP (1) | EP0639073A1 (en, 2012) |
| JP (1) | JPH07506594A (en, 2012) |
| KR (1) | KR950701217A (en, 2012) |
| CN (1) | CN1103533A (en, 2012) |
| AU (1) | AU669269B2 (en, 2012) |
| CA (1) | CA2134098A1 (en, 2012) |
| FI (1) | FI945164A7 (en, 2012) |
| GB (1) | GB9304589D0 (en, 2012) |
| HU (1) | HUT71400A (en, 2012) |
| IL (1) | IL108665A (en, 2012) |
| MY (1) | MY110004A (en, 2012) |
| NZ (1) | NZ261308A (en, 2012) |
| PL (1) | PL305981A1 (en, 2012) |
| TW (1) | TW262465B (en, 2012) |
| WO (1) | WO1994020095A1 (en, 2012) |
| ZA (1) | ZA941126B (en, 2012) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9403909D0 (en) * | 1994-03-01 | 1994-04-20 | Erba Carlo Spa | Ureido derivatives of naphthalenephosphonic acids and process for their preparation |
| GB9504065D0 (en) * | 1995-03-01 | 1995-04-19 | Pharmacia Spa | Poly-pyrrolecarboxamidonaphthalenic acid derivatives |
| GB9602721D0 (en) * | 1996-02-09 | 1996-04-10 | Pharmacia Spa | Biologically active ureido derivatives useful in the treatment of multiple sclerosis |
| WO1999027939A1 (en) | 1997-12-04 | 1999-06-10 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Ureido derivatives of poly-4-amino-2-carboxy-1-methyl pyrrole compounds for inhibition of inflammation |
| GB9727524D0 (en) * | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Synergistic antitumor composition containing a biologically active ureido compound |
| WO1999058126A1 (en) * | 1998-05-11 | 1999-11-18 | The Endowment For Research In Human Biology, Inc. | Use of neomycin for treating angiogenesis-related diseases |
| KR20080035702A (ko) * | 2002-01-11 | 2008-04-23 | 상꾜 가부시키가이샤 | 아미노 알코올 유도체 또는 포스폰산 유도체 및 이들을함유하는 의약 조성물 |
| CN1921847B (zh) | 2004-02-24 | 2010-06-16 | 三共株式会社 | 氨基醇化合物 |
| EP3381897A1 (en) | 2017-03-27 | 2018-10-03 | Leadiant Biosciences SA | Derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1h-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as heparanase inhibitors for the treatment of cancer |
| CN107235866B (zh) | 2017-06-13 | 2019-09-10 | 重庆医科大学 | 一种用于检测次磺酸化蛋白质的荧光探针、制备方法及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986002266A1 (en) * | 1984-10-12 | 1986-04-24 | United States Of America, Represented By The Unite | Use of suramin for clinical treatment of infection with any of the members of the family of human t-cell leukemia (htlv) viruses including lymphadenopathy virus (lav) |
| CA1308516C (en) * | 1987-07-06 | 1992-10-06 | J. William Lown | Oligopeptide anticancer and antiviral agents |
| GB9000644D0 (en) * | 1990-01-11 | 1990-03-14 | Erba Carlo Spa | New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds |
| GB9024738D0 (en) * | 1990-11-14 | 1991-01-02 | Erba Carlo Spa | A new method of treatment of tumor necroisis factor(tnf)-related diseases |
| GB9116896D0 (en) * | 1991-08-06 | 1991-09-18 | Erba Carlo Spa | 3-deoxymannosamine derivatives and process for their preparation |
| GB9216962D0 (en) * | 1992-08-11 | 1992-09-23 | Erba Carlo Spa | Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives |
-
1993
- 1993-03-05 GB GB939304589A patent/GB9304589D0/en active Pending
-
1994
- 1994-01-31 CA CA002134098A patent/CA2134098A1/en not_active Abandoned
- 1994-01-31 WO PCT/EP1994/000268 patent/WO1994020095A1/en not_active Application Discontinuation
- 1994-01-31 NZ NZ261308A patent/NZ261308A/en unknown
- 1994-01-31 PL PL94305981A patent/PL305981A1/xx unknown
- 1994-01-31 AU AU60003/94A patent/AU669269B2/en not_active Ceased
- 1994-01-31 CN CN94190108A patent/CN1103533A/zh active Pending
- 1994-01-31 KR KR1019940703947A patent/KR950701217A/ko not_active Withdrawn
- 1994-01-31 JP JP6519502A patent/JPH07506594A/ja active Pending
- 1994-01-31 HU HU9403177A patent/HUT71400A/hu unknown
- 1994-01-31 EP EP94906181A patent/EP0639073A1/en not_active Ceased
- 1994-02-16 IL IL108665A patent/IL108665A/xx not_active IP Right Cessation
- 1994-02-18 ZA ZA941126A patent/ZA941126B/xx unknown
- 1994-03-03 MY MYPI94000512A patent/MY110004A/en unknown
- 1994-03-04 TW TW083101900A patent/TW262465B/zh active
- 1994-11-02 FI FI945164A patent/FI945164A7/fi unknown
-
1995
- 1995-06-12 US US08/489,621 patent/US5534539A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2134098A1 (en) | 1994-09-15 |
| FI945164A0 (fi) | 1994-11-02 |
| MY110004A (en) | 1997-11-29 |
| ZA941126B (en) | 1994-08-30 |
| JPH07506594A (ja) | 1995-07-20 |
| IL108665A (en) | 1997-03-18 |
| IL108665A0 (en) | 1994-05-30 |
| NZ261308A (en) | 1996-02-27 |
| AU669269B2 (en) | 1996-05-30 |
| KR950701217A (ko) | 1995-03-23 |
| US5534539A (en) | 1996-07-09 |
| WO1994020095A1 (en) | 1994-09-15 |
| CN1103533A (zh) | 1995-06-07 |
| EP0639073A1 (en) | 1995-02-22 |
| GB9304589D0 (en) | 1993-04-21 |
| AU6000394A (en) | 1994-09-26 |
| TW262465B (en, 2012) | 1995-11-11 |
| FI945164A7 (fi) | 1994-11-02 |
| PL305981A1 (en) | 1995-02-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFC4 | Cancellation of temporary protection due to refusal |