HUT65623A - Process for preparing polycyclic guanine derivatives and pharmaceutical preparations containing them - Google Patents

Process for preparing polycyclic guanine derivatives and pharmaceutical preparations containing them Download PDF

Info

Publication number
HUT65623A
HUT65623A HU9204032A HU403292A HUT65623A HU T65623 A HUT65623 A HU T65623A HU 9204032 A HU9204032 A HU 9204032A HU 403292 A HU403292 A HU 403292A HU T65623 A HUT65623 A HU T65623A
Authority
HU
Hungary
Prior art keywords
benzyl
imidazo
purin
dimethyl
methyl
Prior art date
Application number
HU9204032A
Other languages
English (en)
Hungarian (hu)
Other versions
HU9204032D0 (en
Inventor
Bernard R Neustadt
Neil A Lindo
Brian A Mckittrick
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HU9204032D0 publication Critical patent/HU9204032D0/hu
Publication of HUT65623A publication Critical patent/HUT65623A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Filtering Materials (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
HU9204032A 1990-06-21 1991-06-20 Process for preparing polycyclic guanine derivatives and pharmaceutical preparations containing them HUT65623A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54156890A 1990-06-21 1990-06-21

Publications (2)

Publication Number Publication Date
HU9204032D0 HU9204032D0 (en) 1993-03-29
HUT65623A true HUT65623A (en) 1994-07-28

Family

ID=24160139

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9204032A HUT65623A (en) 1990-06-21 1991-06-20 Process for preparing polycyclic guanine derivatives and pharmaceutical preparations containing them

Country Status (21)

Country Link
US (1) US5393755A (2)
EP (1) EP0538332B1 (2)
JP (1) JPH0747589B2 (2)
KR (1) KR960004532B1 (2)
AT (1) ATE155786T1 (2)
AU (1) AU651607B2 (2)
CA (1) CA2085733C (2)
CZ (1) CZ281920B6 (2)
DE (1) DE69126980T2 (2)
FI (1) FI925731A7 (2)
HU (1) HUT65623A (2)
IE (1) IE912126A1 (2)
IL (1) IL98559A0 (2)
NO (1) NO924940L (2)
NZ (1) NZ238609A (2)
OA (1) OA09723A (2)
PL (1) PL169481B1 (2)
RU (1) RU2080322C1 (2)
TW (1) TW197441B (2)
WO (1) WO1991019717A1 (2)
ZA (1) ZA914727B (2)

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US5661153A (en) * 1994-07-19 1997-08-26 Japan Energy Corporation 1-arylpyrimidine derivatives and pharmaceutical use thereof
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US5858694A (en) * 1997-05-30 1999-01-12 Cell Pathways, Inc. Method for identifying compounds for inhibition of cancerous lesions
US6410584B1 (en) * 1998-01-14 2002-06-25 Cell Pathways, Inc. Method for inhibiting neoplastic cells with indole derivatives
US6130053A (en) * 1999-08-03 2000-10-10 Cell Pathways, Inc. Method for selecting compounds for inhibition of neoplastic lesions
US6200771B1 (en) 1998-10-15 2001-03-13 Cell Pathways, Inc. Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
US6133271A (en) * 1998-11-19 2000-10-17 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
US6187779B1 (en) 1998-11-20 2001-02-13 Cell Pathways, Inc. Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
US6369092B1 (en) 1998-11-23 2002-04-09 Cell Pathways, Inc. Method for treating neoplasia by exposure to substituted benzimidazole derivatives
US6077842A (en) * 1998-11-24 2000-06-20 Cell Pathways, Inc. Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives
US6486155B1 (en) 1998-11-24 2002-11-26 Cell Pathways Inc Method of inhibiting neoplastic cells with isoquinoline derivatives
US6034099A (en) * 1998-11-24 2000-03-07 Cell Pathways, Inc. Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones
US6025394A (en) 1999-01-29 2000-02-15 Cell Pathways, Inc. Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols
US6020379A (en) * 1999-02-19 2000-02-01 Cell Pathways, Inc. Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia
ES2166270B1 (es) * 1999-07-27 2003-04-01 Almirall Prodesfarma Sa Derivados de 8-fenil-6,9-dihidro-(1,2,4,)triazolo(3,4-i)purin-5-ona.
US6555547B1 (en) 2000-02-28 2003-04-29 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative
US6569638B1 (en) 2000-03-03 2003-05-27 Cell Pathways, Inc Method for screening compounds for the treatment of neoplasia
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
ATE395349T1 (de) * 2001-08-28 2008-05-15 Schering Corp Polycyclische guanin phosphodiesterase inhibitoren
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CA2465893A1 (en) * 2001-11-09 2003-05-22 Schering Corporation Polycyclic guanine derivative phosphodiesterase v inhibitors
US7342884B2 (en) * 2002-03-13 2008-03-11 Harmonic, Inc. Method and apparatus for one directional communications in bidirectional communications channel
SI1509525T1 (sl) 2002-05-31 2006-12-31 Schering Corp Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
DE60307628T2 (de) * 2002-05-31 2007-08-09 Schering Corporation Verfahren zur herstellung von xanthin phosphodiesterase v inhibitoren und deren vorstufen
WO2005012303A1 (en) * 2003-07-31 2005-02-10 Schering Corporation Metabolite of xanthine phosphodiesterase 5 inhibitor and derivatives thereof useful for treatment of erectile dysfunction
WO2005012293A1 (ja) * 2003-08-01 2005-02-10 Nippon Soda Co., Ltd. フェニルアゾール化合物、製造法および抗酸化薬
KR20060101762A (ko) * 2003-11-21 2006-09-26 쉐링 코포레이션 포스포디에스테라제 ｖ 억제제 제형
US20070004745A1 (en) * 2005-03-25 2007-01-04 Schering-Plough Corporation Methods of treating benign prostatic hyperplasia or lower urinary tract symptoms by using PDE 5 inhibitors
AU2006255028B2 (en) * 2005-06-06 2012-04-19 Intra-Cellular Therapies, Inc. Organic compounds
US20080194592A1 (en) * 2005-08-23 2008-08-14 Intra-Cellular Therapies, Inc. Organic Compounds
US7884202B2 (en) 2005-11-09 2011-02-08 Tosoh Corporation Nucleobase having perfluoroalkyl group and process for producing the same
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
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BRPI0922809A2 (pt) 2008-12-06 2018-05-29 Intracellular Therapies Inc compostos orgânicos
WO2010098839A1 (en) 2009-02-25 2010-09-02 Intra-Cellular Therapies, Inc. Pde 1 inhibitors for ophthalmic disorders
AU2010222289B2 (en) 2009-03-13 2013-07-11 Advinus Therapeutics Private Limited Substituted fused pyrimidine compounds
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JP6166534B2 (ja) 2009-08-05 2017-07-19 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規調節タンパク質および阻害剤
WO2011081915A2 (en) * 2009-12-15 2011-07-07 Cebix Inc. Methods for treating erectile dysfunction in patients with insulin-dependent diabetes
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Also Published As

Publication number Publication date
US5393755A (en) 1995-02-28
HU9204032D0 (en) 1993-03-29
FI925731A0 (fi) 1992-12-17
ATE155786T1 (de) 1997-08-15
FI925731A7 (fi) 1992-12-17
IE912126A1 (en) 1992-01-01
EP0538332B1 (en) 1997-07-23
CA2085733C (en) 1996-03-05
CA2085733A1 (en) 1991-12-22
AU651607B2 (en) 1994-07-28
TW197441B (2) 1993-01-01
NO924940D0 (no) 1992-12-18
WO1991019717A1 (en) 1991-12-26
CZ281920B6 (cs) 1997-04-16
NO924940L (no) 1992-12-18
EP0538332A1 (en) 1993-04-28
RU2080322C1 (ru) 1997-05-27
NZ238609A (en) 1993-12-23
JPH0747589B2 (ja) 1995-05-24
JPH05508647A (ja) 1993-12-02
PL169481B1 (pl) 1996-07-31
DE69126980D1 (de) 1997-09-04
DE69126980T2 (de) 1998-01-08
AU8199291A (en) 1992-01-07
IL98559A0 (en) 1992-07-15
ZA914727B (en) 1992-03-25
CZ374992A3 (en) 1993-10-13
OA09723A (en) 1993-08-30
PL297299A1 (2) 1992-07-13
KR960004532B1 (ko) 1996-04-06

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DFA9 Temporary protection cancelled due to abandonment