HUT64231A - Process for the production of medical preparatives containing heparing and rapamycin for the preventing and treatment of blood-vessel diseases caused by hyper proliferation - Google Patents
Process for the production of medical preparatives containing heparing and rapamycin for the preventing and treatment of blood-vessel diseases caused by hyper proliferationInfo
- Publication number
- HUT64231A HUT64231A HU9301216A HU9301216A HUT64231A HU T64231 A HUT64231 A HU T64231A HU 9301216 A HU9301216 A HU 9301216A HU 9301216 A HU9301216 A HU 9301216A HU T64231 A HUT64231 A HU T64231A
- Authority
- HU
- Hungary
- Prior art keywords
- rapamycin
- preventing
- heparing
- blood
- treatment
- Prior art date
Links
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002930 sirolimus Drugs 0.000 title abstract 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 2
- 210000004204 blood vessel Anatomy 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000035755 proliferation Effects 0.000 title 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/874,895 US5288711A (en) | 1992-04-28 | 1992-04-28 | Method of treating hyperproliferative vascular disease |
| GB929217630A GB9217630D0 (en) | 1992-08-19 | 1992-08-19 | Method of treating hyperproliferative vascular disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9301216D0 HU9301216D0 (en) | 1993-07-28 |
| HUT64231A true HUT64231A (en) | 1993-12-28 |
| HU215388B HU215388B (hu) | 1998-12-28 |
Family
ID=26301459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9301216A HU215388B (hu) | 1992-04-28 | 1993-04-27 | Eljárás heparint és rapamicint tartalmazó, túlburjánzással járó érmegbetegedések kezelésére és megelőzésére alkalmazható szinergetikus gyógyászati készítmény előállítására |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0568310B1 (hu) |
| JP (1) | JP2550277B2 (hu) |
| KR (1) | KR100284210B1 (hu) |
| AT (1) | ATE135226T1 (hu) |
| AU (1) | AU670937B2 (hu) |
| BR (1) | BR9301667A (hu) |
| CA (1) | CA2094858C (hu) |
| DE (1) | DE69301754T2 (hu) |
| DK (1) | DK0568310T3 (hu) |
| ES (1) | ES2085720T3 (hu) |
| GR (1) | GR3019380T3 (hu) |
| HK (1) | HK109097A (hu) |
| HU (1) | HU215388B (hu) |
| SG (1) | SG43030A1 (hu) |
| TW (1) | TW224051B (hu) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| EP1447098A3 (en) | 1993-01-28 | 2005-06-29 | Boston Scientific Limited | Therapeutic inhibitor of vascular smooth muscle cells |
| US5620687A (en) * | 1993-02-25 | 1997-04-15 | Zymogenetics, Inc. | Inhibition of intimal hyperplasia using antibodies to PDGF beta receptors |
| US5976534A (en) * | 1993-02-25 | 1999-11-02 | Zymogenetics, Inc. | Inhibition of intimal hyperplasia using antibodies to PDGF receptors and heparin |
| KR20090090403A (ko) | 1993-07-19 | 2009-08-25 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 항맥관형성 조성물, 당해 조성물로 피복된 스텐트 및 당해 스텐트의 제조방법 |
| US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
| JP4105761B2 (ja) * | 1993-11-19 | 2008-06-25 | アボット・ラボラトリーズ | ラパミシン（マクロライド）の半合成類似体免疫調節剤 |
| US6558798B2 (en) | 1995-02-22 | 2003-05-06 | Scimed Life Systems, Inc. | Hydrophilic coating and substrates coated therewith having enhanced durability and lubricity |
| US5618837A (en) * | 1995-06-07 | 1997-04-08 | Zymogenetics, Inc. | PDGF antagonists III |
| CZ292233B6 (cs) | 1995-06-09 | 2003-08-13 | Novartis Ag | Deriváty rapamycinu a jejich použití jako léčiv |
| DK0835115T3 (da) * | 1995-06-30 | 2004-08-02 | Zymogenetics Inc | 4-(2-(N-2-carboxamidoindo)aminoethyl)-benzensulfonamider eller -sulfonylurinstoffer som PDGF-antagonister |
| BE1009856A5 (fr) | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
| GB9606452D0 (en) * | 1996-03-27 | 1996-06-05 | Sandoz Ltd | Organic compounds |
| US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
| US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| IT1289815B1 (it) | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | Stent per angioplastica e relativo procedimento di produzione |
| US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
| US7399480B2 (en) | 1997-09-26 | 2008-07-15 | Abbott Laboratories | Methods of administering tetrazole-containing rapamycin analogs with other therapeutic substances using medical devices |
| US6890546B2 (en) | 1998-09-24 | 2005-05-10 | Abbott Laboratories | Medical devices containing rapamycin analogs |
| US7445792B2 (en) | 2003-03-10 | 2008-11-04 | Abbott Laboratories | Medical device having a hydration inhibitor |
| US20030129215A1 (en) * | 1998-09-24 | 2003-07-10 | T-Ram, Inc. | Medical devices containing rapamycin analogs |
| US6241762B1 (en) | 1998-03-30 | 2001-06-05 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
| US7208010B2 (en) | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
| US7208011B2 (en) | 2001-08-20 | 2007-04-24 | Conor Medsystems, Inc. | Implantable medical device with drug filled holes |
| RU2152217C1 (ru) * | 1998-04-15 | 2000-07-10 | Институт нефтехимии и катализа АН РБ и УНЦ РАН | Способ формирования антикоагулянтной поверхности |
| US8029561B1 (en) * | 2000-05-12 | 2011-10-04 | Cordis Corporation | Drug combination useful for prevention of restenosis |
| US6214901B1 (en) | 1998-04-27 | 2001-04-10 | Surmodics, Inc. | Bioactive agent release coating |
| US6120847A (en) * | 1999-01-08 | 2000-09-19 | Scimed Life Systems, Inc. | Surface treatment method for stent coating |
| US6419692B1 (en) | 1999-02-03 | 2002-07-16 | Scimed Life Systems, Inc. | Surface protection method for stents and balloon catheters for drug delivery |
| US6156373A (en) | 1999-05-03 | 2000-12-05 | Scimed Life Systems, Inc. | Medical device coating methods and devices |
| DE60026513T2 (de) * | 1999-05-27 | 2006-10-05 | Biocompatibles Uk Ltd., Farnham | Lokale arzneistoffabgabe |
| US6258121B1 (en) | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
| US8236048B2 (en) | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| US7300662B2 (en) | 2000-05-12 | 2007-11-27 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| AU2005202474B2 (en) * | 2000-05-12 | 2007-09-06 | Cardinal Health 529, Llc | Delivery devices for treatment of vascular disease |
| ES2250408T3 (es) * | 2000-05-12 | 2006-04-16 | Cordis Corporation | Dispositivos de administracion para el tratamiento de enfermedades vasculares. |
| WO2002026281A1 (en) * | 2000-09-29 | 2002-04-04 | Cordis Corporation | Coated medical devices |
| ATE343969T1 (de) * | 2000-09-29 | 2006-11-15 | Cordis Corp | Beschichtete medizinische geräte |
| US20020111590A1 (en) | 2000-09-29 | 2002-08-15 | Davila Luis A. | Medical devices, drug coatings and methods for maintaining the drug coatings thereon |
| US6746773B2 (en) | 2000-09-29 | 2004-06-08 | Ethicon, Inc. | Coatings for medical devices |
| US7261735B2 (en) * | 2001-05-07 | 2007-08-28 | Cordis Corporation | Local drug delivery devices and methods for maintaining the drug coatings thereon |
| KR100819895B1 (ko) | 2000-10-16 | 2008-04-07 | 코너 메드시스템즈 인코포레이티드 | 약제 전달용 팽창 가능한 의료 장치 |
| US8182527B2 (en) | 2001-05-07 | 2012-05-22 | Cordis Corporation | Heparin barrier coating for controlled drug release |
| US7247313B2 (en) | 2001-06-27 | 2007-07-24 | Advanced Cardiovascular Systems, Inc. | Polyacrylates coatings for implantable medical devices |
| US7842083B2 (en) | 2001-08-20 | 2010-11-30 | Innovational Holdings, Llc. | Expandable medical device with improved spatial distribution |
| US7056338B2 (en) | 2003-03-28 | 2006-06-06 | Conor Medsystems, Inc. | Therapeutic agent delivery device with controlled therapeutic agent release rates |
| US7108701B2 (en) | 2001-09-28 | 2006-09-19 | Ethicon, Inc. | Drug releasing anastomosis devices and methods for treating anastomotic sites |
| US7097850B2 (en) | 2002-06-18 | 2006-08-29 | Surmodics, Inc. | Bioactive agent release coating and controlled humidity method |
| US7005137B1 (en) | 2002-06-21 | 2006-02-28 | Advanceed Cardiovascular Systems, Inc. | Coating for implantable medical devices |
| US7396539B1 (en) | 2002-06-21 | 2008-07-08 | Advanced Cardiovascular Systems, Inc. | Stent coatings with engineered drug release rate |
| US7217426B1 (en) | 2002-06-21 | 2007-05-15 | Advanced Cardiovascular Systems, Inc. | Coatings containing polycationic peptides for cardiovascular therapy |
| US7491233B1 (en) | 2002-07-19 | 2009-02-17 | Advanced Cardiovascular Systems Inc. | Purified polymers for coatings of implantable medical devices |
| AU2003261100A1 (en) * | 2002-07-25 | 2004-02-16 | Avantec Vascular Corporation | Devices delivering therapeutic agents and methods regarding the same |
| US7438925B2 (en) * | 2002-08-26 | 2008-10-21 | Biovention Holdings Ltd. | Drug eluting coatings for medical implants |
| US7563454B1 (en) | 2003-05-01 | 2009-07-21 | Advanced Cardiovascular Systems, Inc. | Coatings for implantable medical devices |
| US8791171B2 (en) | 2003-05-01 | 2014-07-29 | Abbott Cardiovascular Systems Inc. | Biodegradable coatings for implantable medical devices |
| WO2005097222A1 (en) | 2004-03-26 | 2005-10-20 | Surmodics, Inc. | Process and systems for biocompatible surfaces |
| CA2560507C (en) | 2004-03-26 | 2011-08-16 | Surmodics, Inc. | Composition and method for preparing biocompatible surfaces |
| US8003122B2 (en) * | 2004-03-31 | 2011-08-23 | Cordis Corporation | Device for local and/or regional delivery employing liquid formulations of therapeutic agents |
| US7541048B2 (en) | 2004-04-06 | 2009-06-02 | Surmodics, Inc. | Coating compositions for bioactive agents |
| USD516723S1 (en) | 2004-07-06 | 2006-03-07 | Conor Medsystems, Inc. | Stent wall structure |
| US7244443B2 (en) | 2004-08-31 | 2007-07-17 | Advanced Cardiovascular Systems, Inc. | Polymers of fluorinated monomers and hydrophilic monomers |
| DE112007002054A5 (de) | 2006-07-03 | 2009-06-04 | Hemoteq Ag | Herstellung, Verfahren und Verwendung von wirkstofffreisetzenden Medizinprodukten zur permanenten Offenhaltung von Blutgefässen |
| US9028859B2 (en) | 2006-07-07 | 2015-05-12 | Advanced Cardiovascular Systems, Inc. | Phase-separated block copolymer coatings for implantable medical devices |
| EP2491962A1 (de) | 2007-01-21 | 2012-08-29 | Hemoteq AG | Medizinprodukt zur Behandlung von Verschlüssen von Körperdurchgängen und zur Prävention drohender Wiederverschlüsse |
| US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
| CA2711765A1 (en) | 2008-01-11 | 2009-07-16 | Massachusetts Eye & Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
| JP2012532670A (ja) | 2009-07-10 | 2012-12-20 | ボストン サイエンティフィック サイムド，インコーポレイテッド | 薬剤搬送バルーンのためのナノ結晶の使用 |
| WO2011008393A2 (en) | 2009-07-17 | 2011-01-20 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
| US8889211B2 (en) | 2010-09-02 | 2014-11-18 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
| US8669360B2 (en) | 2011-08-05 | 2014-03-11 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
| US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
-
1993
- 1993-04-26 KR KR1019930006958A patent/KR100284210B1/ko not_active Expired - Lifetime
- 1993-04-26 AU AU37136/93A patent/AU670937B2/en not_active Expired
- 1993-04-26 CA CA002094858A patent/CA2094858C/en not_active Expired - Lifetime
- 1993-04-27 DE DE69301754T patent/DE69301754T2/de not_active Expired - Lifetime
- 1993-04-27 TW TW082103256A patent/TW224051B/zh not_active IP Right Cessation
- 1993-04-27 SG SG1996002641A patent/SG43030A1/en unknown
- 1993-04-27 AT AT93303269T patent/ATE135226T1/de active
- 1993-04-27 DK DK93303269.0T patent/DK0568310T3/da active
- 1993-04-27 ES ES93303269T patent/ES2085720T3/es not_active Expired - Lifetime
- 1993-04-27 HU HU9301216A patent/HU215388B/hu unknown
- 1993-04-27 JP JP5100742A patent/JP2550277B2/ja not_active Expired - Lifetime
- 1993-04-27 EP EP93303269A patent/EP0568310B1/en not_active Expired - Lifetime
- 1993-04-27 BR BR9301667A patent/BR9301667A/pt not_active Application Discontinuation
-
1996
- 1996-03-20 GR GR960400780T patent/GR3019380T3/el unknown
-
1997
- 1997-06-26 HK HK109097A patent/HK109097A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU9301216D0 (en) | 1993-07-28 |
| ATE135226T1 (de) | 1996-03-15 |
| CA2094858C (en) | 2004-06-15 |
| KR940005280A (ko) | 1994-03-21 |
| AU670937B2 (en) | 1996-08-08 |
| DE69301754D1 (de) | 1996-04-18 |
| JPH0680573A (ja) | 1994-03-22 |
| HK109097A (en) | 1997-08-22 |
| TW224051B (hu) | 1994-05-21 |
| HU215388B (hu) | 1998-12-28 |
| SG43030A1 (en) | 1997-10-17 |
| ES2085720T3 (es) | 1996-06-01 |
| AU3713693A (en) | 1993-11-04 |
| BR9301667A (pt) | 1993-11-03 |
| DE69301754T2 (de) | 1996-08-08 |
| CA2094858A1 (en) | 1993-10-29 |
| KR100284210B1 (ko) | 2001-03-02 |
| EP0568310A1 (en) | 1993-11-03 |
| GR3019380T3 (en) | 1996-06-30 |
| EP0568310B1 (en) | 1996-03-13 |
| DK0568310T3 (da) | 1996-07-29 |
| JP2550277B2 (ja) | 1996-11-06 |
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Owner name: WYETH (DELAWARE ALLAMBAN BEJEGYZETT CEG), US |