HUT61591A - Process for producing haemoglobin and its analogs - Google Patents

Process for producing haemoglobin and its analogs

Info

Publication number
HUT61591A
HUT61591A HU905111A HU511190A HUT61591A HU T61591 A HUT61591 A HU T61591A HU 905111 A HU905111 A HU 905111A HU 511190 A HU511190 A HU 511190A HU T61591 A HUT61591 A HU T61591A
Authority
HU
Hungary
Prior art keywords
polypeptide
producing
alpha
haemoglobin
analogs
Prior art date
Application number
HU905111A
Other languages
English (en)
Other versions
HU905111D0 (en
Inventor
Stephen J Hoffman
Douglas L Looker
Mary S Rosendal
Gary L Stetler
Michael Wagenbach
Original Assignee
Somatogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Somatogen Inc filed Critical Somatogen Inc
Publication of HU905111D0 publication Critical patent/HU905111D0/hu
Publication of HUT61591A publication Critical patent/HUT61591A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6445—Haemoglobin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
HU905111A 1989-05-10 1990-05-10 Process for producing haemoglobin and its analogs HUT61591A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34962389A 1989-05-10 1989-05-10
US37416189A 1989-06-30 1989-06-30
US37911689A 1989-07-13 1989-07-13

Publications (2)

Publication Number Publication Date
HU905111D0 HU905111D0 (en) 1992-02-28
HUT61591A true HUT61591A (en) 1993-01-28

Family

ID=27407902

Family Applications (1)

Application Number Title Priority Date Filing Date
HU905111A HUT61591A (en) 1989-05-10 1990-05-10 Process for producing haemoglobin and its analogs

Country Status (18)

Country Link
EP (3) EP0700997B1 (hu)
JP (1) JP3013902B2 (hu)
KR (1) KR920701434A (hu)
AT (2) ATE142692T1 (hu)
AU (1) AU635744B2 (hu)
CA (1) CA2050601C (hu)
DE (2) DE69028448T2 (hu)
DK (1) DK0402300T3 (hu)
ES (2) ES2204926T3 (hu)
FI (2) FI105104B (hu)
GR (1) GR3021106T3 (hu)
HU (1) HUT61591A (hu)
IE (1) IE970086A1 (hu)
IL (1) IL94361A (hu)
NO (2) NO304027B1 (hu)
NZ (1) NZ233642A (hu)
SG (1) SG47987A1 (hu)
WO (1) WO1990013645A1 (hu)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022849A (en) * 1987-05-16 2000-02-08 Baxter Biotech Technology Saarl Mutant recombinant hemoglobins containing heme pocket mutations
US6204009B1 (en) 1988-05-16 2001-03-20 BAXTER BIOTECH TECHNOLOGY SàRL Nucleic acids encoding mutant recombinant hemoglobins containing heme pocket mutations
US5545727A (en) * 1989-05-10 1996-08-13 Somatogen, Inc. DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin
US6150506A (en) * 1989-05-10 2000-11-21 Baxter Biotech Technology Sarl Modified hemoglobin-like compounds and methods of purifying same
US5844090A (en) * 1994-05-09 1998-12-01 Somatogen, Inc. Modified hemoglobin-like compounds
US5599907A (en) * 1989-05-10 1997-02-04 Somatogen, Inc. Production and use of multimeric hemoglobins
WO1991013158A1 (en) * 1990-02-28 1991-09-05 Delta Biotechnology Limited Protein production in yeast
NZ237827A (en) * 1990-04-16 1994-03-25 Strohtech Inc Pure globin chain or haem-binding fragment thereof and methods for its production
US6172039B1 (en) 1990-04-16 2001-01-09 Apex Bioscience, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
US5610137A (en) * 1990-12-20 1997-03-11 The Uab Research Foundation Transgenic, cross-linked hemoglobin
WO1992011283A1 (en) * 1990-12-20 1992-07-09 The University Of Alabama Research Foundation Transgenic, cross-linked hemoglobin
US5714345A (en) * 1990-12-24 1998-02-03 Pharmaceutical Proteins Limited Increased expression of a gene by a second transferred mammary gland specific sequence transgenic
GB9028062D0 (en) * 1990-12-24 1991-02-13 Agricultural & Food Res Production of transgenic animals
WO1993008831A1 (en) * 1991-10-30 1993-05-13 Strohtech, Inc. Expression of recombinant hemoglobin and hemoglobin variants in yeast
ATE168014T1 (de) * 1991-11-08 1998-07-15 Somatogen Inc Hämoglobine als arzneimittelabgabesystem
FR2688784B1 (fr) * 1992-03-18 1995-06-30 Pasteur Merieux Serums Vacc Transporteur d'oxygene.
US5939391A (en) * 1993-03-31 1999-08-17 Pro-Neuron, Inc. Hemoglobin alpha chain peptide fragments useful for inhibiting stem cell proliferation
US6610654B2 (en) 1993-03-31 2003-08-26 Wellstat Therapeutics Corporation Inhibitor of stem cell proliferation and uses thereof
JPH08510997A (ja) * 1993-03-31 1996-11-19 プロ−ニューロン，インコーポレイテッド 幹細胞増殖インヒビターおよびその使用
US5554638A (en) * 1993-05-24 1996-09-10 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5612310A (en) * 1993-05-24 1997-03-18 Duke University Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
US5665869A (en) * 1993-11-15 1997-09-09 Somatogen, Inc. Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
US6140071A (en) * 1994-01-27 2000-10-31 Somatogen, Inc. Proteins with mutations to decrease N-terminal methylation
US6242417B1 (en) 1994-03-08 2001-06-05 Somatogen, Inc. Stabilized compositions containing hemoglobin
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin
WO1997004110A1 (en) * 1995-07-14 1997-02-06 Somatogen, Inc. Methods for increasing protein expression
US5824511A (en) * 1995-08-01 1998-10-20 University Technology Corporation Method for enhancing the production of hemoproteins
US6812207B1 (en) 1995-10-23 2004-11-02 William Marsh Rice University Hemoglobin mutants that reduce heme loss
JPH11514237A (ja) * 1995-10-23 1999-12-07 ライス ユニバーシティ ヘム損失を減少させるヘモグロビン変異体
CA2236794A1 (en) * 1995-11-30 1997-06-05 Bruce A. Kerwin Method for control of functionality during cross-linking of hemoglobins
US6218513B1 (en) 1995-12-22 2001-04-17 Baxter Biotech Technology Sarl Globins containing binding domains
WO1997023631A2 (en) * 1995-12-22 1997-07-03 Somatogen, Inc. Globins containing binding domains
US5861483A (en) 1996-04-03 1999-01-19 Pro-Neuron, Inc. Inhibitor of stem cell proliferation and uses thereof
AU4990697A (en) * 1996-10-18 1998-05-15 Eli Lilly And Company Methods of reducing the levels of protoporphyrin ix in recombinant hemoglobin preparations
EP1950298A3 (en) 1997-05-02 2008-12-24 Baxter Biotech Technology S.A.R.L. Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging
DE10036491A1 (de) * 2000-07-25 2002-02-07 Roche Diagnostics Gmbh Expression von Alkalischer Phosphatase in Hefe
IL157378A0 (en) 2001-03-09 2004-02-19 Genentech Inc Process for production of polypeptides
US7494974B2 (en) 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
EP2178551A4 (en) * 2007-07-24 2010-07-21 Sanare Invest As NEW PEPTIDES
EP2058398A1 (en) * 2007-11-09 2009-05-13 Nipro Corporation Production of recombinant human hemoglobin using pichia yeast
KR101584540B1 (ko) * 2014-04-16 2016-01-14 박병용 대형 식품용기 자동 세척장치
US10752672B1 (en) * 2019-02-01 2020-08-25 Cheer Global Limited Recombinant hemoglobins and methods of preparation and use thereof
CN114929736A (zh) * 2020-01-10 2022-08-19 尹特荣生物科技株式会社 一种利用大肠杆菌制备猪肌红蛋白的方法
US20230073947A1 (en) * 2020-01-10 2023-03-09 Intron Biotechnology, Inc. A method for preparing bovine myoglobin using escherichia coli
CN116203144B (zh) * 2022-05-11 2023-10-27 重庆医科大学附属儿童医院 测定血红蛋白中各型珠蛋白链比率的方法及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3924943A (en) 1974-06-11 1975-12-09 Xerox Corp Segmented biased transfer member
US4769326A (en) 1980-02-29 1988-09-06 The Regents Of The University Of California Expression linkers
US4338397A (en) 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
US4551433A (en) 1981-05-18 1985-11-05 Genentech, Inc. Microbial hybrid promoters
US4620948A (en) 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4599197A (en) 1982-12-22 1986-07-08 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
GB8412517D0 (en) 1984-05-16 1984-06-20 Nagai K Recombinant fusion proteins
US4600531A (en) 1984-06-27 1986-07-15 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
US4598064A (en) 1984-06-27 1986-07-01 University Of Iowa Research Foundation Alpha-alpha cross-linked hemoglobins
US4774180A (en) 1986-02-26 1988-09-27 Massachusetts Institute Of Technology Construction and application of polyproteins
US4704692A (en) 1986-09-02 1987-11-03 Ladner Robert C Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
GB8701001D0 (en) 1987-01-19 1987-02-18 Gordon D G Ceiling tiles
WO1988006601A1 (en) 1987-03-02 1988-09-07 Genex Corporation Gene repressors
EP0561245A1 (en) * 1987-05-16 1993-09-22 Somatogenetics International, Inc. Blood substitutes comprising recombinant hemoglobin
GB8711614D0 (en) * 1987-05-16 1987-06-24 Medical Res Council Proteins

Also Published As

Publication number Publication date
CA2050601C (en) 2000-09-19
EP0402300A2 (en) 1990-12-12
GR3021106T3 (en) 1996-12-31
FI107938B (fi) 2001-10-31
IL94361A (en) 1995-07-31
NO973848L (no) 1997-08-21
NO315568B1 (no) 2003-09-22
JP3013902B2 (ja) 2000-02-28
IL94361A0 (en) 1991-03-10
ES2204926T3 (es) 2004-05-01
IE970086A1 (en) 2000-02-23
EP0402300A3 (en) 1991-01-30
EP0700997A1 (en) 1996-03-13
EP0402300B1 (en) 1996-09-11
WO1990013645A1 (en) 1990-11-15
NO914387L (no) 1991-11-08
EP0700997B1 (en) 2003-07-30
NO914387D0 (no) 1991-11-08
DK0402300T3 (da) 1996-09-30
NO304027B1 (no) 1998-10-12
DE69034091T2 (de) 2004-04-22
NZ233642A (en) 1992-12-23
NO973848D0 (no) 1997-08-21
EP1380645A2 (en) 2004-01-14
AU635744B2 (en) 1993-04-01
KR920701434A (ko) 1992-08-11
DE69028448D1 (de) 1996-10-17
FI20000025A (fi) 2000-01-05
CA2050601A1 (en) 1990-11-11
ES2093640T3 (es) 1997-01-01
FI915279A0 (fi) 1991-11-08
FI105104B (fi) 2000-06-15
DE69028448T2 (de) 1997-02-06
SG47987A1 (en) 1998-04-17
AU5675690A (en) 1990-11-29
ATE142692T1 (de) 1996-09-15
DE69034091D1 (de) 2003-09-04
JPH05503627A (ja) 1993-06-17
ATE246246T1 (de) 2003-08-15
HU905111D0 (en) 1992-02-28

Similar Documents

Publication Publication Date Title
HUT61591A (en) Process for producing haemoglobin and its analogs
AU6733487A (en) Mammalian interleukin-4
ATE61407T1 (de) Muteine biologisch aktiver proteine mit verringertem cysteingehalt, ihre herstellung, formulierungen, die solche muteine enthalten sowie strukturgene, vektoren und organismen, die zur herstellung der genannten muteine geeignet sind und deren herstellung.
PL240926A1 (en) Process for preparing animal's interferons
FI102282B1 (fi) Menetelmä O-glykosyloidun IGF-1:n valmistamiseksi
AU4854985A (en) Novel hormones and methods for making, using and assaying same
ES2014613A6 (es) Metodo para la preparacion de un modulo de expresion util en la produccion de polipeptidos.

Legal Events

Date Code Title Description
DGB9 Succession in title of applicant

Owner name: BAXTER BIOTECH TECHNOLOGY S.A.R.L., CH

DFC4 Cancellation of temporary protection due to refusal