HUT48278A - Process for production of rhenin-hindering dipeptides and medical preparatives containing them - Google Patents

Process for production of rhenin-hindering dipeptides and medical preparatives containing them

Info

Publication number
HUT48278A
HUT48278A HU885066A HU506688A HUT48278A HU T48278 A HUT48278 A HU T48278A HU 885066 A HU885066 A HU 885066A HU 506688 A HU506688 A HU 506688A HU T48278 A HUT48278 A HU T48278A
Authority
HU
Hungary
Prior art keywords
rhenin
dipeptides
hindering
production
preparatives containing
Prior art date
Application number
HU885066A
Other languages
English (en)
Other versions
HU203118B (en
Inventor
Adalbert Wagner
Heinz-Werner Kleemann
Dieter Ruppert
Bernward Schoelkens
Hans-Joerg Urbach
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of HUT48278A publication Critical patent/HUT48278A/hu
Publication of HU203118B publication Critical patent/HU203118B/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06008Dipeptides with the first amino acid being neutral
    • C07K5/06078Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HU885066A 1987-09-30 1988-09-29 Process for producing renin inhibiting dipeptides and pharmaceutical compositions comprising same HU203118B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873732971 DE3732971A1 (de) 1987-09-30 1987-09-30 Renin-hemmende dipeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung

Publications (2)

Publication Number Publication Date
HUT48278A true HUT48278A (en) 1989-05-29
HU203118B HU203118B (en) 1991-05-28

Family

ID=6337246

Family Applications (1)

Application Number Title Priority Date Filing Date
HU885066A HU203118B (en) 1987-09-30 1988-09-29 Process for producing renin inhibiting dipeptides and pharmaceutical compositions comprising same

Country Status (13)

Country Link
EP (1) EP0310015A3 (hu)
JP (1) JPH01121258A (hu)
KR (1) KR890005146A (hu)
AU (1) AU624579B2 (hu)
DE (1) DE3732971A1 (hu)
DK (1) DK543788A (hu)
FI (1) FI884455A (hu)
HU (1) HU203118B (hu)
IL (1) IL87912A0 (hu)
NO (1) NO884324L (hu)
NZ (1) NZ226361A (hu)
PT (1) PT88622B (hu)
ZA (1) ZA887264B (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL87614A0 (en) * 1987-09-16 1989-01-31 Abbott Lab Peptidylheterocycles
DE3804793A1 (de) * 1988-02-16 1989-08-24 Hoechst Ag Renin-hemmende aminosaeurederivate
DE3814325A1 (de) * 1988-04-28 1989-11-09 Merck Patent Gmbh Aminosaeurederivate
DE3841520A1 (de) * 1988-12-09 1990-06-13 Hoechst Ag Enzymhemmende harnstoffderivate von dipeptiden, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3913290A1 (de) * 1989-04-22 1990-10-25 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
TW225540B (hu) * 1990-06-28 1994-06-21 Shionogi & Co
US5554641A (en) * 1995-03-20 1996-09-10 Horwell; David C. Nonpeptides as tachykinin antagonists
JP4696352B2 (ja) * 2000-11-30 2011-06-08 トヨタ自動車株式会社 車両用電源装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
DE3601248A1 (de) * 1986-01-17 1987-07-23 Hoechst Ag Substituierte 4-amino-3-hydroxybuttersaeure-derivate, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
ZA87563B (en) * 1986-02-03 1987-09-30 Squibb & Sons Inc N-heterocyclic alcohol renin inhibitors
DE3627877A1 (de) * 1986-07-30 1988-02-04 Hoechst Ag Renin-hemmende di- und tripeptide, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung
HU204285B (en) * 1986-10-31 1991-12-30 Pfizer Process for producing renin-inhibiting polypeptides of small molecule mass and pharmaceutical compositions containing them
NL8800100A (nl) * 1987-01-21 1988-08-16 Sandoz Ag Nieuwe peptidederivaten en werkwijzen voor het bereiden en toepassen van deze derivaten.

Also Published As

Publication number Publication date
DK543788A (da) 1989-03-31
NZ226361A (en) 1991-12-23
ZA887264B (en) 1989-06-28
DE3732971A1 (de) 1989-04-20
KR890005146A (ko) 1989-05-13
NO884324L (no) 1989-03-31
PT88622B (pt) 1993-07-30
HU203118B (en) 1991-05-28
FI884455A0 (fi) 1988-09-28
NO884324D0 (no) 1988-09-29
PT88622A (pt) 1989-07-31
AU2295988A (en) 1989-06-29
EP0310015A2 (de) 1989-04-05
EP0310015A3 (de) 1992-05-20
JPH01121258A (ja) 1989-05-12
DK543788D0 (da) 1988-09-29
IL87912A0 (en) 1989-03-31
AU624579B2 (en) 1992-06-18
FI884455A (fi) 1989-03-31

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee