HUT47552A - Process for producing 10-dihydro-10-deoxo-11-aza-erythronolid a derivatives and pharmaceutical compositions containing them as active components - Google Patents

Process for producing 10-dihydro-10-deoxo-11-aza-erythronolid a derivatives and pharmaceutical compositions containing them as active components

Info

Publication number
HUT47552A
HUT47552A HU881778A HU177888A HUT47552A HU T47552 A HUT47552 A HU T47552A HU 881778 A HU881778 A HU 881778A HU 177888 A HU177888 A HU 177888A HU T47552 A HUT47552 A HU T47552A
Authority
HU
Hungary
Prior art keywords
erythronolid
deoxo
aza
dihydro
derivatives
Prior art date
Application number
HU881778A
Other languages
English (en)
Other versions
HU198913B (en
Inventor
Slobodan Djokic
Hrvoje Krnjevic
Nevenka Lopotar
Olga Carevic
Gabrijela Kobrehel
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from YU163187A external-priority patent/YU44641B/xx
Priority claimed from YU8588A external-priority patent/YU45054B/xx
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Publication of HUT47552A publication Critical patent/HUT47552A/hu
Publication of HU198913B publication Critical patent/HU198913B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HU881778A 1987-09-03 1988-04-08 Process for producing 10-dihydro-10-deoxo-11-aza-erythronolide a-derivatives and pharmaceutical compositions containing them as active components HU198913B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
YU163187A YU44641B (en) 1987-09-03 1987-09-03 Process for preparing derivatives of 10-dihydro-10-deoxo-11-azaeritronolides
YU8588A YU45054B (en) 1988-01-18 1988-01-18 Process for preparing derivative of 10-dihydro-10-deoxo-11-azaerithronolide a

Publications (2)

Publication Number Publication Date
HUT47552A true HUT47552A (en) 1989-03-28
HU198913B HU198913B (en) 1989-12-28

Family

ID=27130708

Family Applications (1)

Application Number Title Priority Date Filing Date
HU881778A HU198913B (en) 1987-09-03 1988-04-08 Process for producing 10-dihydro-10-deoxo-11-aza-erythronolide a-derivatives and pharmaceutical compositions containing them as active components

Country Status (12)

Country Link
US (1) US4886792A (hu)
EP (1) EP0283055B1 (hu)
JP (1) JPH01287076A (hu)
CN (1) CN1020452C (hu)
BG (2) BG49825A3 (hu)
CA (1) CA1296000C (hu)
CS (1) CS274462B2 (hu)
DE (1) DE3860503D1 (hu)
HU (1) HU198913B (hu)
PL (1) PL155159B1 (hu)
RO (1) RO105811B1 (hu)
RU (1) RU2007398C1 (hu)

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US5049557A (en) * 1986-05-13 1991-09-17 Chai-Tech Corporation Metallo-organic salt compounds and pharmaceutical uses thereof
EP0432975A1 (en) * 1989-12-08 1991-06-19 Merck & Co. Inc. Cyclic renin inhibitors
US5194605A (en) * 1989-12-08 1993-03-16 Merck & Co., Inc. Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3S,4S)-5-cyclohexyl-3,4-di-hydroxy pentanoic acid or 2-substituted (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhexanoic acid or its analogs
US5254682A (en) * 1989-12-08 1993-10-19 Merck & Co., Inc. Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs
YU45590A (sh) * 1990-03-07 1992-07-20 PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o. Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
FR2691464B1 (fr) * 1992-05-21 1995-06-02 Roussel Uclaf Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
US5185365A (en) * 1992-06-24 1993-02-09 Cornell Research Foundation, Inc. Insect deterrent azamcrolides
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
AU7961498A (en) * 1997-06-26 1999-01-19 Merck & Co., Inc. 9a-azalides, compositions containing such compounds and methods of treatment
WO1999000125A1 (en) * 1997-06-27 1999-01-07 Merck & Co., Inc. 9a-aza-3-ketolides, compositions containing such compounds and methods of treatment
EP1036083B9 (en) * 1997-10-16 2005-01-12 Pliva - Istrazivacki Institut d.o.o. Novel 9a-azalides
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
HUP0201516A3 (en) * 1999-05-24 2003-03-28 Pfizer Prod Inc 13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
AU2003237150A1 (en) * 2002-05-02 2003-11-17 University Hospitals Of Cleveland Compositions and methods for treating inflammatory connective tissue diseases
CA2489402A1 (en) 2002-07-08 2004-01-15 Pliva-Istrazivacki Institut D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
PL374646A1 (en) * 2002-07-08 2005-10-31 Pliva-Istrazivacki Institutt D.O.O. Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
EP1551865B1 (en) 2002-07-08 2009-04-22 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Hybrid molecules of macrolides with steroidal/non-steroidal anti-inflammatory molecules
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
HRP20030324A2 (en) * 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
ES2337915T3 (es) 2004-10-27 2010-04-30 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugados con adtividad antiinflamatoria.
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
JP2008526945A (ja) * 2005-01-14 2008-07-24 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗炎症活性を有する９ａ−カルバモイルおよびチオカルバモイルアザライド
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
US20100031410A1 (en) * 2008-08-08 2010-02-11 Linda Clark Multi-Positionable Face Shield
US8796232B2 (en) 2008-10-24 2014-08-05 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN101619085B (zh) * 2009-08-11 2015-04-22 沈阳药科大学 红霉素衍生物及其作为肿瘤细胞增殖抑制剂的用途
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
CN104470527B (zh) 2012-03-27 2019-05-28 森普拉制药公司 用于施用大环内酯抗生素的肠胃外制剂
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CA2908620A1 (en) * 2013-04-10 2014-10-16 Probiotic Pharmaceuticals Aps Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
GB201608236D0 (en) * 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
CN106478542A (zh) * 2016-10-17 2017-03-08 南开大学 一种大环内脂类衍生物盐、其制备方法及用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives

Also Published As

Publication number Publication date
RO105811B1 (ro) 1992-12-30
CN1031703A (zh) 1989-03-15
JPH01287076A (ja) 1989-11-17
PL155159B1 (en) 1991-10-31
HU198913B (en) 1989-12-28
CN1020452C (zh) 1993-05-05
EP0283055A2 (en) 1988-09-21
DE3860503D1 (de) 1990-10-04
US4886792A (en) 1989-12-12
RU2007398C1 (ru) 1994-02-15
BG49825A3 (en) 1992-02-14
CS274462B2 (en) 1991-04-11
CA1296000C (en) 1992-02-18
CS253388A2 (en) 1990-09-12
EP0283055A3 (en) 1989-03-15
BG60586B1 (bg) 1995-09-29
PL272025A1 (en) 1989-03-06
EP0283055B1 (en) 1990-08-29

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee