BG49825A3 - Method for preparing of 10- dihydro- 10- deoxo- 11- asaeritronolides a - Google Patents

Method for preparing of 10- dihydro- 10- deoxo- 11- asaeritronolides a

Info

Publication number
BG49825A3
BG49825A3 BG83878A BG8387888A BG49825A3 BG 49825 A3 BG49825 A3 BG 49825A3 BG 83878 A BG83878 A BG 83878A BG 8387888 A BG8387888 A BG 8387888A BG 49825 A3 BG49825 A3 BG 49825A3
Authority
BG
Bulgaria
Prior art keywords
asaeritronolides
deoxo
dihydro
preparing
Prior art date
Application number
BG83878A
Other languages
English (en)
Inventor
Slobodan Djokic
Nevenka Lopotar
Gabrijela Kobrehel
Hrvoje Krnjevic
Olga Carevic
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from YU163187A external-priority patent/YU44641B/xx
Priority claimed from YU85/88A external-priority patent/YU45054B/xx
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Publication of BG49825A3 publication Critical patent/BG49825A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
BG83878A 1987-09-03 1988-04-26 Method for preparing of 10- dihydro- 10- deoxo- 11- asaeritronolides a BG49825A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
YU163187A YU44641B (en) 1987-09-03 1987-09-03 Process for preparing derivatives of 10-dihydro-10-deoxo-11-azaeritronolides
YU85/88A YU45054B (en) 1988-01-18 1988-01-18 Process for preparing derivative of 10-dihydro-10-deoxo-11-azaerithronolide a

Publications (1)

Publication Number Publication Date
BG49825A3 true BG49825A3 (en) 1992-02-14

Family

ID=27130708

Family Applications (1)

Application Number Title Priority Date Filing Date
BG83878A BG49825A3 (en) 1987-09-03 1988-04-26 Method for preparing of 10- dihydro- 10- deoxo- 11- asaeritronolides a

Country Status (12)

Country Link
US (1) US4886792A (xx)
EP (1) EP0283055B1 (xx)
JP (1) JPH01287076A (xx)
CN (1) CN1020452C (xx)
BG (1) BG49825A3 (xx)
CA (1) CA1296000C (xx)
CS (1) CS274462B2 (xx)
DE (1) DE3860503D1 (xx)
HU (1) HU198913B (xx)
PL (1) PL155159B1 (xx)
RO (1) RO105811B1 (xx)
RU (1) RU2007398C1 (xx)

Families Citing this family (44)

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US5049557A (en) * 1986-05-13 1991-09-17 Chai-Tech Corporation Metallo-organic salt compounds and pharmaceutical uses thereof
US5254682A (en) * 1989-12-08 1993-10-19 Merck & Co., Inc. Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs
US5194605A (en) * 1989-12-08 1993-03-16 Merck & Co., Inc. Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3S,4S)-5-cyclohexyl-3,4-di-hydroxy pentanoic acid or 2-substituted (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhexanoic acid or its analogs
CA2031745A1 (en) * 1989-12-08 1991-06-09 William J. Greenlee Cyclic renin inhibitors containing 2-substituted(3s, 4s)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3s, 4s)-5-cyclohexyl-3,4-dihydroxy-pentanoic acid or 2 -substituted (4s, 5s)-5-amino-6- yclohexyl-4-hydroxyhexanoic acid or its analogs
YU45590A (sh) * 1990-03-07 1992-07-20 PLIVA FARMACEVTSKA, KEMIJSKA, PREHRAMBENA I KOZMETIČKA INDUSTRIJA s.p.o. Novi kompleksi odnosno helati antibiotika s dvovalentnim i/ili trovalentnim metalima i postupci za njihovo dobijanje
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
FR2691464B1 (fr) * 1992-05-21 1995-06-02 Roussel Uclaf Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
US5185365A (en) * 1992-06-24 1993-02-09 Cornell Research Foundation, Inc. Insect deterrent azamcrolides
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
WO1999000124A1 (en) * 1997-06-26 1999-01-07 Merck & Co., Inc. 9a-azalides, compositions containing such compounds and methods of treatment
AU7986098A (en) * 1997-06-27 1999-01-19 Merck & Co., Inc. 9a-aza-3-ketolides, compositions containing such compounds and methods of treatment
DE69836697T2 (de) * 1997-10-16 2007-10-04 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Neue 3,6-Hemiketale der 9a-Azalidklasse
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
WO2000071557A1 (en) * 1999-05-24 2000-11-30 Pfizer Products Inc. 13-methyl-erythromycin derivatives
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
US20030207819A1 (en) * 2002-05-02 2003-11-06 Moskowitz Roland W. Compositions and methods for treating inflammatory connective tissue diseases
CN1665831A (zh) 2002-07-08 2005-09-07 普利瓦研究院有限公司 作为甾类/非甾类抗炎、抗肿瘤和抗病毒活性分子载体的新化合物、组合物
RS20050008A (xx) * 2002-07-08 2007-06-04 Pliva-Istraživački Institut D.O.O., Nova jedinjenja,kompozicije i metode za lečenje inflamatornih oboljenja i stanja
NZ537716A (en) * 2002-07-08 2007-05-31 Glaxosmithkline Zagreb Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
EP1805202B1 (en) 2004-10-27 2009-12-30 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Conjugates with anti-inflammatory activity
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
EP1846003A1 (en) * 2005-01-14 2007-10-24 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl and thiocarbamoyl azalides with anti-inflammatory activity
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US20100031410A1 (en) * 2008-08-08 2010-02-11 Linda Clark Multi-Positionable Face Shield
DK2358379T3 (en) 2008-10-24 2016-03-07 Cempra Pharmaceuticals Inc BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN101619085B (zh) * 2009-08-11 2015-04-22 沈阳药科大学 红霉素衍生物及其作为肿瘤细胞增殖抑制剂的用途
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh) 2013-03-15 2015-12-23 森普拉制药公司 用于制备大环内酯抗菌剂的收敛方法
WO2014166503A1 (en) 2013-04-10 2014-10-16 Probiotic Pharmaceuticals Aps Azithromycin antimicrobial derivatives with non-antibiotic pharmaceutical effect
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds
CN106478542A (zh) * 2016-10-17 2017-03-08 南开大学 一种大环内脂类衍生物盐、其制备方法及用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives

Also Published As

Publication number Publication date
DE3860503D1 (de) 1990-10-04
PL272025A1 (en) 1989-03-06
RO105811B1 (ro) 1992-12-30
CN1031703A (zh) 1989-03-15
HUT47552A (en) 1989-03-28
EP0283055A3 (en) 1989-03-15
EP0283055A2 (en) 1988-09-21
EP0283055B1 (en) 1990-08-29
US4886792A (en) 1989-12-12
CS253388A2 (en) 1990-09-12
JPH01287076A (ja) 1989-11-17
PL155159B1 (en) 1991-10-31
CN1020452C (zh) 1993-05-05
CA1296000C (en) 1992-02-18
CS274462B2 (en) 1991-04-11
HU198913B (en) 1989-12-28
RU2007398C1 (ru) 1994-02-15

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