HUP9901560A2 - Kombinációs kémiai könyvtárak tömeg alapján történő kódolása és minőségi elemzése - Google Patents

Kombinációs kémiai könyvtárak tömeg alapján történő kódolása és minőségi elemzése

Info

Publication number
HUP9901560A2
HUP9901560A2 HU9901560A HUP9901560A HUP9901560A2 HU P9901560 A2 HUP9901560 A2 HU P9901560A2 HU 9901560 A HU9901560 A HU 9901560A HU P9901560 A HUP9901560 A HU P9901560A HU P9901560 A2 HUP9901560 A2 HU P9901560A2
Authority
HU
Hungary
Prior art keywords
mass
combinatorial libraries
qualitative analysis
based encoding
stone
Prior art date
Application number
HU9901560A
Other languages
English (en)
Inventor
Hendrik Mario Geysen
Daniel Stuart Kinder
Craig Daniel Wagner
Original Assignee
Glaxo Group Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd. filed Critical Glaxo Group Ltd.
Publication of HUP9901560A2 publication Critical patent/HUP9901560A2/hu
Publication of HUP9901560A3 publication Critical patent/HUP9901560A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B01J2219/00581—Mass
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

A találmány szerinti módszerrel szilárd fázisú kőmbinációs szintetikűskőnstrűkciókat izőtópősan jelzett részek bevitelével nem kémiai kóddallátják el, majd tömegspektrőmetriásan, tömegalapú magmágnesesrezőnancia spektrőszkópiával vagy tömegalapú infravörösspektrőszkópiával végzett elemzéssel fizikailag azőnősítják anagyszámú kőmbinációs szintézisterméket, illetve a reakció történetét. ŕ
HU9901560A 1996-04-08 1997-04-08 Mass-based encoding and qualitative analysis of combinatorial libraries HUP9901560A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1497096P 1996-04-08 1996-04-08

Publications (2)

Publication Number Publication Date
HUP9901560A2 true HUP9901560A2 (hu) 1999-08-30
HUP9901560A3 HUP9901560A3 (en) 2000-09-28

Family

ID=21768844

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901560A HUP9901560A3 (en) 1996-04-08 1997-04-08 Mass-based encoding and qualitative analysis of combinatorial libraries

Country Status (10)

Country Link
US (1) US6475807B1 (hu)
EP (1) EP0863858B1 (hu)
AT (1) ATE258904T1 (hu)
AU (1) AU739256B2 (hu)
CA (1) CA2242171A1 (hu)
CZ (1) CZ217698A3 (hu)
DE (1) DE69727466T2 (hu)
ES (1) ES2213823T3 (hu)
HU (1) HUP9901560A3 (hu)
WO (1) WO1997037953A1 (hu)

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AU1591301A (en) 1999-11-09 2001-06-06 Sri International Workstation, apparatus, and methods for the high-throughput synthesis, screeningand characterization of combinatorial libraries
AU2001234779A1 (en) 2000-02-03 2001-08-14 Nanoscale Combinatorial Synthesis, Inc. Structure identification methods using mass measurements
US20010031475A1 (en) * 2000-02-23 2001-10-18 Gallop Mark A. Self-encoded combinatorial synthesis of compound multiplets
MXPA02008253A (es) * 2000-02-25 2002-11-29 Wyeth Corp Metodos de diseno de farmacos basados en la estructura usando em/rmn.
GB0006141D0 (en) 2000-03-14 2000-05-03 Brax Group Ltd Mass labels
US6582726B1 (en) 2000-06-21 2003-06-24 Smithkline Beecham Corporation Cross linked solid supports for solid phase synthesis
US6584411B1 (en) 2000-07-26 2003-06-24 Smithkline Beecham Corporation Methods to facilitate the calculation of yields of reaction products
US6576472B1 (en) 2000-07-26 2003-06-10 Smithkline Beecham Corporation Chemical constructs for solution phase chemistry
CA2420330A1 (en) * 2000-08-25 2002-02-28 Donald Naki Detecting polymers and polymer fragments
AU2002367839A1 (en) * 2001-07-16 2003-11-17 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US20050003430A1 (en) * 2001-08-17 2005-01-06 Naki Donald P. Detecting polymers and polymer fragments
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CA2393726A1 (en) * 2002-07-16 2004-01-16 Steven J. Locke Quantitative proteomics via isotopically differentiated derivatization
US7820378B2 (en) 2002-11-27 2010-10-26 Sequenom, Inc. Fragmentation-based methods and systems for sequence variation detection and discovery
DK2259068T3 (en) 2003-01-16 2013-11-11 Caprotec Bioanalytics Gmbh Capture compounds and methods for analyzing the proteome
WO2004070352A2 (en) * 2003-01-30 2004-08-19 Applera Corporation Methods, mixtures, kits and compositions pertaining to analyte determination
DE112004001212B4 (de) * 2003-07-03 2014-07-24 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Verfahren für die Analyse von Isotopensignaturen und die Massenanalyse
US9394565B2 (en) 2003-09-05 2016-07-19 Agena Bioscience, Inc. Allele-specific sequence variation analysis
JP4838725B2 (ja) * 2003-11-26 2011-12-14 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド クワイエットゾーン中の質量スペクトルデータの分析
US7355045B2 (en) * 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
US20050148087A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US20050148771A1 (en) * 2004-01-05 2005-07-07 Applera Corporation. Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof
CA2557997C (en) * 2004-03-01 2012-01-31 Applera Corporation Determination of analyte characteristics based upon binding properties
WO2005098050A2 (en) 2004-03-26 2005-10-20 Sequenom, Inc. Base specific cleavage of methylation-specific amplification products in combination with mass analysis
US20070054345A1 (en) * 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
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US20060183238A1 (en) * 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
US20070037286A1 (en) * 2005-02-09 2007-02-15 Subhasish Purkayastha Thyroxine-containing compound analysis methods
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CN101454488A (zh) * 2006-05-26 2009-06-10 阿普里拉股份有限公司 用于羟基化化合物的标签试剂和方法
US7906341B2 (en) * 2006-06-30 2011-03-15 Dh Technologies Development Pte, Ltd. Methods, mixtures, kits and compositions pertaining to analyte determination
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Also Published As

Publication number Publication date
EP0863858A1 (en) 1998-09-16
HUP9901560A3 (en) 2000-09-28
DE69727466T2 (de) 2004-12-16
CZ217698A3 (cs) 1998-12-16
DE69727466D1 (de) 2004-03-11
ATE258904T1 (de) 2004-02-15
ES2213823T3 (es) 2004-09-01
CA2242171A1 (en) 1997-10-16
AU739256B2 (en) 2001-10-04
WO1997037953A1 (en) 1997-10-16
US6475807B1 (en) 2002-11-05
EP0863858B1 (en) 2004-02-04
AU2723797A (en) 1997-10-29

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Legal Events

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