AR040711A1 - Un metodo para verificacion de calidad/control de calidad para proceso de bioensayo de alto rendimiento - Google Patents

Un metodo para verificacion de calidad/control de calidad para proceso de bioensayo de alto rendimiento

Info

Publication number
AR040711A1
AR040711A1 AR20030102704A ARP030102704A AR040711A1 AR 040711 A1 AR040711 A1 AR 040711A1 AR 20030102704 A AR20030102704 A AR 20030102704A AR P030102704 A ARP030102704 A AR P030102704A AR 040711 A1 AR040711 A1 AR 040711A1
Authority
AR
Argentina
Prior art keywords
biochip
bioassay
model
sera
quality
Prior art date
Application number
AR20030102704A
Other languages
English (en)
Inventor
Ben Hitt
Peter J Levine
Emmanuel F Petricoin Iii
Original Assignee
Us Agriculture
Correlogic Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Agriculture, Correlogic Systems Inc filed Critical Us Agriculture
Publication of AR040711A1 publication Critical patent/AR040711A1/es

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Evolutionary Biology (AREA)
  • Data Mining & Analysis (AREA)
  • Bioethics (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Evolutionary Computation (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Microbiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Software Systems (AREA)
  • Food Science & Technology (AREA)
  • Artificial Intelligence (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Signal Processing (AREA)
  • Chemical Kinetics & Catalysis (AREA)

Abstract

La presente se refiere a un método de verificación de calidad/control de calidad para procesos de bioensayo de alto rendimiento. El método incluye generar un modelo de proceso de bioensayo, y luego comparar los datos espectrales en base a una combinación de un biochip y un suero de prueba con el modelo de proceso de bioensayo para determinar si la muestra y el proceso de bioensayo están produciendo datos aceptables. Alternativamente, el método puede incluir comparar datos espectrales en base a una combinación de suero y diluyentes usados en un proceso de electropulverización con el modelo de proceso de bioensayo. Si el proceso de bioensayo y la muestra de prueba coinciden con el moldeo, el espectro producido puede ser analizado. Reivindicación 1: Un método de verificación de calidad/control de calidad para un proceso de bioensayo de alto rendimiento caracterizado porque comprende: seleccionar un grupo diverso de sueros, el grupo diverso de sueros tiene características distintas; aplicar cada uno de los sueros de grupo diverso a por lo menos un punto en una pluralidad de distintos biochip; realizar una espectrometría de masa en cada uno de la pluralidad de biochips; generar un modelo de biochip basado por lo menos parcialmente en los espectros obtenidos de la pluralidad de distintos sueros o biochips; aplicar un suero de prueba a un punto de un biochip; realizar una espectrometría de masa a un suero de prueba para obtener un espectro asociado con el suero de prueba; hacer coincidir el espectro obtenida de dicha espectrometría con el modelo de biochip; y determinar si el espectro coincide con el modelo de biochip.
AR20030102704A 2002-07-29 2003-07-28 Un metodo para verificacion de calidad/control de calidad para proceso de bioensayo de alto rendimiento AR040711A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39883102P 2002-07-29 2002-07-29

Publications (1)

Publication Number Publication Date
AR040711A1 true AR040711A1 (es) 2005-04-13

Family

ID=32312442

Family Applications (3)

Application Number Title Priority Date Filing Date
AR20030102705A AR040712A1 (es) 2002-07-29 2003-07-28 Un metodo para inicialar un modelo de control para proceso de bioensayo
AR20030102704A AR040711A1 (es) 2002-07-29 2003-07-28 Un metodo para verificacion de calidad/control de calidad para proceso de bioensayo de alto rendimiento
AR20030102706A AR040713A1 (es) 2002-07-29 2003-07-28 Un metodo para verificacion de calidad/control de calidad para procesos de ionizacion por electro-pulverizacion

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AR20030102705A AR040712A1 (es) 2002-07-29 2003-07-28 Un metodo para inicialar un modelo de control para proceso de bioensayo

Family Applications After (1)

Application Number Title Priority Date Filing Date
AR20030102706A AR040713A1 (es) 2002-07-29 2003-07-28 Un metodo para verificacion de calidad/control de calidad para procesos de ionizacion por electro-pulverizacion

Country Status (5)

Country Link
US (5) US7333896B2 (es)
AR (3) AR040712A1 (es)
AU (3) AU2003268031A1 (es)
TW (3) TW200407540A (es)
WO (3) WO2004011905A2 (es)

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WO2004011904A3 (en) 2004-07-08
AU2003268031A1 (en) 2004-02-16
TW200403434A (en) 2004-03-01
US7333896B2 (en) 2008-02-19
US7395160B2 (en) 2008-07-01
US20040053333A1 (en) 2004-03-18
TW200407540A (en) 2004-05-16
WO2004011905A2 (en) 2004-02-05
AU2003261273A1 (en) 2004-02-16
AU2003304161A1 (en) 2005-01-21
AU2003304161A8 (en) 2005-01-21
US20040058372A1 (en) 2004-03-25
US20080195323A1 (en) 2008-08-14
TW200407543A (en) 2004-05-16
US7333895B2 (en) 2008-02-19
US20040058388A1 (en) 2004-03-25
AR040712A1 (es) 2005-04-20
WO2004106887A3 (en) 2005-05-12
AR040713A1 (es) 2005-04-20
US20080103063A1 (en) 2008-05-01
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AU2003268031A8 (en) 2004-02-16
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