HUP9901338A2 - Eljárás kinolon-karbonsavak vagy naftiridin-karbonsavak előállítására szabad bázis formájú alakban - Google Patents

Eljárás kinolon-karbonsavak vagy naftiridin-karbonsavak előállítására szabad bázis formájú alakban

Info

Publication number
HUP9901338A2
HUP9901338A2 HU9901338A HUP9901338A HUP9901338A2 HU P9901338 A2 HUP9901338 A2 HU P9901338A2 HU 9901338 A HU9901338 A HU 9901338A HU P9901338 A HUP9901338 A HU P9901338A HU P9901338 A2 HUP9901338 A2 HU P9901338A2
Authority
HU
Hungary
Prior art keywords
carboxylic acids
naphthyridine
acid salt
free base
base form
Prior art date
Application number
HU9901338A
Other languages
English (en)
Inventor
Gary Jay Dozeman
Kenneth Thomas Porter
James Norton Wemple
Original Assignee
Warner-Lambert Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Co. filed Critical Warner-Lambert Co.
Publication of HUP9901338A2 publication Critical patent/HUP9901338A2/hu
Publication of HUP9901338A3 publication Critical patent/HUP9901338A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

A találmány tárgya eljárás kinőlőn-karbőnsavak vagy naftiridin-karbőnsavak szabad bázisú főrmájú előállítására. A találmány szerintúgy járnak el, hőgy a) valamely kinőlőn-karbőnsav-sót vagy naftiridin-karbőnsav-sót őldószer-rendszerben őldanak és így őldatőt képeznek, b)a kinőlőn-karbőnsav-sót vagy naftiridin-karbőnsav-sót tartalmazóőldatőt kalciűmsóval elegyítik őlyan mennyiségben, hőgy a kinőlőn-karbőnsav-só vagy a naftiridin-karbőnsav-só tömegére vőnatkőztatva akalciűm mennyisége körülbelül 0,01% - körülbelül 5,0% közötti legyen,majd egy bázissal elegyítik és az elegyítés sőrán csapadék képződik;tővábbá c) a kapőtt csapadékőt elválasztják. A találmány szerintikészítmények parenterális dózis főrmákban aktív hatóanyagkéntalkalmazhatók szisztémás bakteriális fertőzések kezelésére. ŕ
HU9901338A 1995-05-26 1996-04-26 Method for making quinolone carboxylic acids or naphthyridine carboxylic acids in free base form HUP9901338A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/452,208 US5602254A (en) 1995-05-26 1995-05-26 Method for making quinoline carboxylic acids or naphthyridine carboxylic acids in free base form
PCT/US1996/005899 WO1996037475A1 (en) 1995-05-26 1996-04-26 Method for making quinolone carboxylic acids or naphthyridine carboxylic acids in free base form

Publications (2)

Publication Number Publication Date
HUP9901338A2 true HUP9901338A2 (hu) 2000-04-28
HUP9901338A3 HUP9901338A3 (en) 2002-10-28

Family

ID=23795530

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901338A HUP9901338A3 (en) 1995-05-26 1996-04-26 Method for making quinolone carboxylic acids or naphthyridine carboxylic acids in free base form

Country Status (18)

Country Link
US (2) US5602254A (hu)
EP (1) EP0828714B1 (hu)
JP (1) JPH11505835A (hu)
AT (1) ATE199146T1 (hu)
CA (1) CA2220080C (hu)
CZ (1) CZ289107B6 (hu)
DE (1) DE69611782T2 (hu)
DK (1) DK0828714T3 (hu)
EE (1) EE03522B1 (hu)
ES (1) ES2156277T3 (hu)
GR (1) GR3035818T3 (hu)
HU (1) HUP9901338A3 (hu)
MX (1) MX9708562A (hu)
NZ (1) NZ307053A (hu)
PL (1) PL184063B1 (hu)
PT (1) PT828714E (hu)
SK (1) SK282666B6 (hu)
WO (1) WO1996037475A1 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19716684B4 (de) * 1997-04-21 2009-11-26 Deep Blue Technology Ag Anker-/Ankerketten-Überwachungsvorrichtung
CN1343128B (zh) 1999-03-17 2010-04-21 第一制药株式会社 药物组合物
RU2007104026A (ru) * 2004-07-02 2008-08-10 Дайити Фармасьютикал Ко., Лтд. (JP) Содержащая хинолон лекарственная композиция

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
DE3248507A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen Mikrobizide mittel auf chinoloncarbonsaeure basis
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US4771054A (en) * 1985-01-23 1988-09-13 Warner-Lambert Company Antibacterial agents
DE3713672A1 (de) * 1987-04-24 1988-11-17 Bayer Ag Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
RO101477A2 (ro) * 1988-06-01 1991-11-18 Intreprinderea Textila, Timisoara, Judetul Timis, Ro Procedeu de obtinere a 3,3'-imino-bis-propionamidei
US4950787A (en) * 1988-08-24 1990-08-21 Monsanto Company Chemical process
US4867901A (en) * 1988-08-24 1989-09-19 Bosch Richard J Improved process for reacting salts of D,L-tartaric and maleic acid in the production of ether carboxylate mixtures
US5290794A (en) * 1992-10-27 1994-03-01 Warner Lambert Co. Soluble calcium lactate antibacterial complexes as non-irritating parenteral forms

Also Published As

Publication number Publication date
CA2220080A1 (en) 1996-11-28
WO1996037475A1 (en) 1996-11-28
DE69611782T2 (de) 2001-06-21
PL184063B1 (pl) 2002-08-30
CZ366797A3 (cs) 1998-05-13
HUP9901338A3 (en) 2002-10-28
SK156497A3 (en) 1998-03-04
MX9708562A (es) 1997-12-31
EE03522B1 (et) 2001-10-15
EE9700290A (et) 1998-06-15
US5783585A (en) 1998-07-21
GR3035818T3 (en) 2001-07-31
CZ289107B6 (cs) 2001-11-14
CA2220080C (en) 2006-11-21
DE69611782D1 (de) 2001-03-22
AU5630996A (en) 1996-12-11
ATE199146T1 (de) 2001-02-15
AU698104B2 (en) 1998-10-22
NZ307053A (en) 1998-12-23
EP0828714A1 (en) 1998-03-18
JPH11505835A (ja) 1999-05-25
EP0828714B1 (en) 2001-02-14
US5602254A (en) 1997-02-11
PT828714E (pt) 2001-05-31
PL323527A1 (en) 1998-03-30
DK0828714T3 (da) 2001-03-26
ES2156277T3 (es) 2001-06-16
SK282666B6 (sk) 2002-11-06

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees