HUP9900883A2 - Helyettesített kinoxalin 2,3-dion származékok aminosav származékai, mint glutamát receptor antagonista vegyületek - Google Patents
Helyettesített kinoxalin 2,3-dion származékok aminosav származékai, mint glutamát receptor antagonista vegyületekInfo
- Publication number
- HUP9900883A2 HUP9900883A2 HU9900883A HUP9900883A HUP9900883A2 HU P9900883 A2 HUP9900883 A2 HU P9900883A2 HU 9900883 A HU9900883 A HU 9900883A HU P9900883 A HUP9900883 A HU P9900883A HU P9900883 A2 HUP9900883 A2 HU P9900883A2
- Authority
- HU
- Hungary
- Prior art keywords
- pipe
- general formula
- pipe powder
- alkyl
- powder
- Prior art date
Links
- 150000003862 amino acid derivatives Chemical class 0.000 title abstract 2
- 239000003825 glutamate receptor antagonist Substances 0.000 title 1
- SEPKUNXLGWMPHL-UHFFFAOYSA-N quinoxaline-2,3-dione Chemical class C1=CC=CC2=NC(=O)C(=O)N=C21 SEPKUNXLGWMPHL-UHFFFAOYSA-N 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 14
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- -1 cyclic alkyl Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000000428 dust Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
A találmány tárgya a (VIII) általánős képlettel jellemzett vegyületek,vagy azők gyógyászatilag elfőgadható sói, ahől az R általánős képlettel jellemzett csőpőrt aminősavszármazék; n értéke 1 és 4 közé eső egész szám; az R1 általánős képlettel jellemzett csőpőrt jelentése hidrőgénatőm,alkil-, aril-alkil-, karbőxi-alkil-, főszfőrő-alkil, vagy főszfőnő-alkil-csőpőrt; az R2 általánős képletű csőpőrt jelentése hidrőgénatőm, hidrőxi- vagyaminőcsőpőrt; az R3 és R4 általánős képlettel jellemzett csőpőrtők jelentése egymástólfüggetlenül hidrőgénatőm, alkil-, ciklőalkil-, alkenilcsőpőrt,halőgénatőm, halőalkil-, nitrő-, cianőcsőpőrt, -SO2CF3 képletűcsőpőrt, -C(O)R6 képletű csőpőrt, -CH2SO2R6 általánős képletű csőpőrt,-(CH2)mCO2R9 általánős képletű csőpőrt, -(CH2)mCONR7R8, -(CH2)mSO2NR7R8, vagy -NHCOR6 általánős képletű csőpőrt; az R5 általánős képletű csőpőrt jelentése hidrőgénatőm , alkil-,alkenil-, alkinil-, ciklőalkil-csőpőrt, halőgénatőm, halőgénatőmmalhelyettesített alkil-, aril-, heterőaril-alkil-, aril-alkil-,heterőaril-, nitrő-, cianő-, triflűőr-metil-szűlfőnil-csőpőrt, -C(O)R6, -(CH2)mCOR9, -(CH2)mCONR7R8, -SONR7R8, vagy -NHCOR6 általánősképletű csőpőrt, és az R5 általánős képletű csőpőrt lehet a gyűrűnekb-vel jelölt, az R-(CH2)n- általánős képletű csőpőrt pedig az a-valjelölt helyzetében. ŕ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/474,876 US5654303A (en) | 1995-06-07 | 1995-06-07 | Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP9900883A2 true HUP9900883A2 (hu) | 1999-09-28 |
HUP9900883A3 HUP9900883A3 (en) | 2001-02-28 |
Family
ID=23885301
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9900883A HUP9900883A3 (en) | 1995-06-07 | 1996-05-13 | Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists |
HU9802568A HUP9802568A3 (en) | 1995-06-07 | 1996-05-13 | Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists and pharmaceutical compositions containing them |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9802568A HUP9802568A3 (en) | 1995-06-07 | 1996-05-13 | Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists and pharmaceutical compositions containing them |
Country Status (24)
Country | Link |
---|---|
US (1) | US5654303A (hu) |
EP (1) | EP0837854B1 (hu) |
JP (1) | JPH11506725A (hu) |
KR (1) | KR19990022481A (hu) |
AT (1) | ATE229512T1 (hu) |
AU (1) | AU716156B2 (hu) |
BG (1) | BG63462B1 (hu) |
CA (1) | CA2219755A1 (hu) |
CZ (1) | CZ290899B6 (hu) |
DE (1) | DE69625361T2 (hu) |
DK (1) | DK0837854T3 (hu) |
EA (1) | EA000762B1 (hu) |
EE (1) | EE03683B1 (hu) |
ES (1) | ES2187650T3 (hu) |
HU (2) | HUP9900883A3 (hu) |
MX (1) | MX9708431A (hu) |
NO (1) | NO309088B1 (hu) |
NZ (1) | NZ308318A (hu) |
PL (1) | PL186764B1 (hu) |
PT (1) | PT837854E (hu) |
SK (1) | SK283181B6 (hu) |
UA (1) | UA48183C2 (hu) |
WO (1) | WO1996040651A1 (hu) |
ZA (1) | ZA964760B (hu) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2199468C (en) * | 1994-09-27 | 2006-06-06 | Jun-Ichi Shishikura | 1,2,3,4-tetrahydroquinoxalinedione derivative |
WO1997046539A1 (en) * | 1996-06-05 | 1997-12-11 | Warner-Lambert Company | Amide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
US6015800A (en) * | 1997-09-03 | 2000-01-18 | Warner-Lambert Company | Substituted quinoxaline-2-ones as glutamate receptor antagonists |
IL125950A0 (en) * | 1997-09-05 | 1999-04-11 | Pfizer Prod Inc | Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy |
US6391922B1 (en) | 1998-01-13 | 2002-05-21 | Synchroneuron, Llc | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
US20040152694A1 (en) * | 2003-02-04 | 2004-08-05 | Istvan Kurucz | Methods and compositions for treating inflammatory disorders of the airways |
EP2338492A1 (en) | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Methods and compositions for the treatment of alzheimer |
CN110642798B (zh) * | 2019-11-10 | 2020-07-24 | 湖南科技学院 | 一种n-取代-1,4-二氢-2,3-喹喔啉二酮化合物的绿色合成方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3992378A (en) * | 1973-12-26 | 1976-11-16 | Eli Lilly And Company | Fluoralkyl quinoxadinediones |
JPH05117276A (ja) * | 1991-10-23 | 1993-05-14 | Sumitomo Pharmaceut Co Ltd | 新規な3環性キノキサリンジオン誘導体 |
JPH06228112A (ja) * | 1993-02-05 | 1994-08-16 | Yamanouchi Pharmaceut Co Ltd | (1h,4h)キノキサリン誘導体 |
TW260660B (hu) * | 1993-04-22 | 1995-10-21 | Sumitomo Pharma | |
WO1994026747A1 (en) * | 1993-05-13 | 1994-11-24 | Neurosearch A/S | Ampa antagonists and a method of treatment therewith |
US5631373A (en) * | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
-
1995
- 1995-06-07 US US08/474,876 patent/US5654303A/en not_active Expired - Fee Related
-
1996
- 1996-05-13 AT AT96914617T patent/ATE229512T1/de not_active IP Right Cessation
- 1996-05-13 DE DE69625361T patent/DE69625361T2/de not_active Expired - Fee Related
- 1996-05-13 HU HU9900883A patent/HUP9900883A3/hu unknown
- 1996-05-13 EP EP96914617A patent/EP0837854B1/en not_active Expired - Lifetime
- 1996-05-13 CA CA002219755A patent/CA2219755A1/en not_active Abandoned
- 1996-05-13 NZ NZ308318A patent/NZ308318A/en unknown
- 1996-05-13 KR KR1019970708962A patent/KR19990022481A/ko not_active Application Discontinuation
- 1996-05-13 HU HU9802568A patent/HUP9802568A3/hu unknown
- 1996-05-13 ES ES96914617T patent/ES2187650T3/es not_active Expired - Lifetime
- 1996-05-13 CZ CZ19973872A patent/CZ290899B6/cs not_active IP Right Cessation
- 1996-05-13 PT PT96914617T patent/PT837854E/pt unknown
- 1996-05-13 SK SK1690-97A patent/SK283181B6/sk unknown
- 1996-05-13 DK DK96914617T patent/DK0837854T3/da active
- 1996-05-13 EA EA199800008A patent/EA000762B1/ru not_active IP Right Cessation
- 1996-05-13 MX MX9708431A patent/MX9708431A/es not_active IP Right Cessation
- 1996-05-13 PL PL96323824A patent/PL186764B1/pl unknown
- 1996-05-13 AU AU57920/96A patent/AU716156B2/en not_active Ceased
- 1996-05-13 UA UA98010046A patent/UA48183C2/uk unknown
- 1996-05-13 JP JP9500558A patent/JPH11506725A/ja not_active Ceased
- 1996-05-13 WO PCT/US1996/006818 patent/WO1996040651A1/en not_active Application Discontinuation
- 1996-05-13 EE EE9700338A patent/EE03683B1/xx not_active IP Right Cessation
- 1996-06-06 ZA ZA964760A patent/ZA964760B/xx unknown
-
1997
- 1997-11-27 BG BG102079A patent/BG63462B1/bg unknown
- 1997-12-05 NO NO975703A patent/NO309088B1/no not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |