EE03683B1 - Asendatud kinoksaliin-2,3-dioonide alküülamiinderivaadid kui glutamaatretseptori antagonistid - Google Patents
Asendatud kinoksaliin-2,3-dioonide alküülamiinderivaadid kui glutamaatretseptori antagonistidInfo
- Publication number
- EE03683B1 EE03683B1 EE9700338A EE9700338A EE03683B1 EE 03683 B1 EE03683 B1 EE 03683B1 EE 9700338 A EE9700338 A EE 9700338A EE 9700338 A EE9700338 A EE 9700338A EE 03683 B1 EE03683 B1 EE 03683B1
- Authority
- EE
- Estonia
- Prior art keywords
- substituted quinoxaline
- dione
- receptor antagonists
- glutamate receptor
- alkylamine derivatives
- Prior art date
Links
- SEPKUNXLGWMPHL-UHFFFAOYSA-N quinoxaline-2,3-dione Chemical class C1=CC=CC2=NC(=O)C(=O)N=C21 SEPKUNXLGWMPHL-UHFFFAOYSA-N 0.000 title abstract 2
- 150000003973 alkyl amines Chemical class 0.000 title 1
- 239000003825 glutamate receptor antagonist Substances 0.000 title 1
- 206010008118 cerebral infarction Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010002660 Anoxia Diseases 0.000 abstract 1
- 241000976983 Anoxia Species 0.000 abstract 1
- 201000006474 Brain Ischemia Diseases 0.000 abstract 1
- 206010008120 Cerebral ischaemia Diseases 0.000 abstract 1
- 206010014498 Embolic stroke Diseases 0.000 abstract 1
- 229940122459 Glutamate antagonist Drugs 0.000 abstract 1
- 208000010496 Heart Arrest Diseases 0.000 abstract 1
- 208000016988 Hemorrhagic Stroke Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000013016 Hypoglycemia Diseases 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 206010028923 Neonatal asphyxia Diseases 0.000 abstract 1
- 208000037212 Neonatal hypoxic and ischemic brain injury Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 239000003194 amino acid receptor blocking agent Substances 0.000 abstract 1
- 230000007953 anoxia Effects 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 208000020658 intracerebral hemorrhage Diseases 0.000 abstract 1
- 208000001286 intracranial vasospasm Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000004090 neuroprotective agent Substances 0.000 abstract 1
- 208000033300 perinatal asphyxia Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000005809 status epilepticus Diseases 0.000 abstract 1
- 230000009424 thromboembolic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/474,876 US5654303A (en) | 1995-06-07 | 1995-06-07 | Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
| PCT/US1996/006818 WO1996040651A1 (en) | 1995-06-07 | 1996-05-13 | Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE9700338A EE9700338A (et) | 1998-06-15 |
| EE03683B1 true EE03683B1 (et) | 2002-04-15 |
Family
ID=23885301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9700338A EE03683B1 (et) | 1995-06-07 | 1996-05-13 | Asendatud kinoksaliin-2,3-dioonide alküülamiinderivaadid kui glutamaatretseptori antagonistid |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5654303A (hu) |
| EP (1) | EP0837854B1 (hu) |
| JP (1) | JPH11506725A (hu) |
| KR (1) | KR19990022481A (hu) |
| AT (1) | ATE229512T1 (hu) |
| AU (1) | AU716156B2 (hu) |
| BG (1) | BG63462B1 (hu) |
| CA (1) | CA2219755A1 (hu) |
| CZ (1) | CZ290899B6 (hu) |
| DE (1) | DE69625361T2 (hu) |
| DK (1) | DK0837854T3 (hu) |
| EA (1) | EA000762B1 (hu) |
| EE (1) | EE03683B1 (hu) |
| ES (1) | ES2187650T3 (hu) |
| HU (2) | HUP9900883A3 (hu) |
| MX (1) | MX9708431A (hu) |
| NO (1) | NO309088B1 (hu) |
| NZ (1) | NZ308318A (hu) |
| PL (1) | PL186764B1 (hu) |
| PT (1) | PT837854E (hu) |
| SK (1) | SK283181B6 (hu) |
| UA (1) | UA48183C2 (hu) |
| WO (1) | WO1996040651A1 (hu) |
| ZA (1) | ZA964760B (hu) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996010023A1 (fr) * | 1994-09-27 | 1996-04-04 | Yamanouchi Pharmaceutical Co., Ltd. | Derive de 1,2,3,4-tetrahydroquinoxalindione |
| WO1997046539A1 (en) * | 1996-06-05 | 1997-12-11 | Warner-Lambert Company | Amide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
| US6015800A (en) * | 1997-09-03 | 2000-01-18 | Warner-Lambert Company | Substituted quinoxaline-2-ones as glutamate receptor antagonists |
| IL125950A0 (en) * | 1997-09-05 | 1999-04-11 | Pfizer Prod Inc | Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy |
| US6391922B1 (en) | 1998-01-13 | 2002-05-21 | Synchroneuron, Llc | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
| US20040152694A1 (en) * | 2003-02-04 | 2004-08-05 | Istvan Kurucz | Methods and compositions for treating inflammatory disorders of the airways |
| EP2338492A1 (en) | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Methods and compositions for the treatment of alzheimer |
| CN110642798B (zh) * | 2019-11-10 | 2020-07-24 | 湖南科技学院 | 一种n-取代-1,4-二氢-2,3-喹喔啉二酮化合物的绿色合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3992378A (en) * | 1973-12-26 | 1976-11-16 | Eli Lilly And Company | Fluoralkyl quinoxadinediones |
| JPH05117276A (ja) * | 1991-10-23 | 1993-05-14 | Sumitomo Pharmaceut Co Ltd | 新規な３環性キノキサリンジオン誘導体 |
| JPH06228112A (ja) * | 1993-02-05 | 1994-08-16 | Yamanouchi Pharmaceut Co Ltd | （１ｈ，４ｈ）キノキサリン誘導体 |
| TW260660B (hu) * | 1993-04-22 | 1995-10-21 | Sumitomo Pharma | |
| NZ267081A (en) * | 1993-05-13 | 1997-11-24 | Neurosearch As | Hetero-fused indole and quinoxaline compounds and medicaments thereof |
| US5631373A (en) * | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
-
1995
- 1995-06-07 US US08/474,876 patent/US5654303A/en not_active Expired - Fee Related
-
1996
- 1996-05-13 UA UA98010046A patent/UA48183C2/uk unknown
- 1996-05-13 HU HU9900883A patent/HUP9900883A3/hu unknown
- 1996-05-13 SK SK1690-97A patent/SK283181B6/sk unknown
- 1996-05-13 CA CA002219755A patent/CA2219755A1/en not_active Abandoned
- 1996-05-13 EE EE9700338A patent/EE03683B1/xx not_active IP Right Cessation
- 1996-05-13 EP EP96914617A patent/EP0837854B1/en not_active Expired - Lifetime
- 1996-05-13 CZ CZ19973872A patent/CZ290899B6/cs not_active IP Right Cessation
- 1996-05-13 EA EA199800008A patent/EA000762B1/ru not_active IP Right Cessation
- 1996-05-13 MX MX9708431A patent/MX9708431A/es not_active IP Right Cessation
- 1996-05-13 KR KR1019970708962A patent/KR19990022481A/ko not_active Application Discontinuation
- 1996-05-13 DK DK96914617T patent/DK0837854T3/da active
- 1996-05-13 DE DE69625361T patent/DE69625361T2/de not_active Expired - Fee Related
- 1996-05-13 JP JP9500558A patent/JPH11506725A/ja not_active Ceased
- 1996-05-13 AT AT96914617T patent/ATE229512T1/de not_active IP Right Cessation
- 1996-05-13 ES ES96914617T patent/ES2187650T3/es not_active Expired - Lifetime
- 1996-05-13 WO PCT/US1996/006818 patent/WO1996040651A1/en not_active Application Discontinuation
- 1996-05-13 PT PT96914617T patent/PT837854E/pt unknown
- 1996-05-13 AU AU57920/96A patent/AU716156B2/en not_active Ceased
- 1996-05-13 HU HU9802568A patent/HUP9802568A3/hu unknown
- 1996-05-13 NZ NZ308318A patent/NZ308318A/en unknown
- 1996-05-13 PL PL96323824A patent/PL186764B1/pl unknown
- 1996-06-06 ZA ZA964760A patent/ZA964760B/xx unknown
-
1997
- 1997-11-27 BG BG102079A patent/BG63462B1/bg unknown
- 1997-12-05 NO NO975703A patent/NO309088B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EE03352B1 (et) | Asendatud kinoksaliin-2,3-diooni derivaatide aminohappe derivaadid kui glutamaatretseptori antagonistid | |
| RU94046067A (ru) | Замещенные 1,2,3,4-тетрагидроизохинолины, промежуточные продукты, фармкомпозиция и способ лечения | |
| EE03683B1 (et) | Asendatud kinoksaliin-2,3-dioonide alküülamiinderivaadid kui glutamaatretseptori antagonistid | |
| GT200200084A (es) | Sales tartrato de 5, 8,14-triazatetraciclo[10.3.1.0 2,11.0 4,9] hexadeca-2(11),3,5,7,9-pentaeno ycomposicionesfarmaceuticas de las mismas | |
| AP2002002664A0 (en) | Cyclohexylamine derivative as subtype selective NMDA receptor antagonists. | |
| MY120976A (en) | 2-amino-6-(2-substituted-4-phenoxy)- substituted- pyridines | |
| AP2002002697A0 (en) | Biciclic cyclohexylamines and their use as NMDA receptor antagonists. | |
| MX9708563A (es) | Derivados aminociclicos de quinoxalina 2, 3-diones substituidos como antagonistas del receptor de glutamato. | |
| AU2001263130A1 (en) | Bicyclic cyclohexylamines and their use as nmda receptor antagonists | |
| CO4410330A1 (es) | Nuevos derivados de bencimidazol farmacologicamente activos y sus sales de adicion acida | |
| ATE267600T1 (de) | Mikroemulsionen zur transdermalen verabreichung von apomorphin für die behandlung von morbus parkinson | |
| NO960048D0 (no) | Difluorstaton-analoger | |
| CO5310533A1 (es) | Derivados de amida de 2,3-dionas de quinoxalina como antago- nistas de receptor de glutamato | |
| MXPA04003215A (es) | Derivados de triazapina como agentes neurotroficos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20021231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20050513 |