HUP9900502A2 - 8-Ciano-1-ciklopropil-7-(2,8-diazabiciklo[4,3,0]nonán-8-il)-6-fluor-1,4-dihidro-4-oxo-3-kinolin-karbonsavak és származékaik, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra - Google Patents

8-Ciano-1-ciklopropil-7-(2,8-diazabiciklo[4,3,0]nonán-8-il)-6-fluor-1,4-dihidro-4-oxo-3-kinolin-karbonsavak és származékaik, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények, eljárás előállításukra

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Publication number
HUP9900502A2
HUP9900502A2 HU9900502A HUP9900502A HUP9900502A2 HU P9900502 A2 HUP9900502 A2 HU P9900502A2 HU 9900502 A HU9900502 A HU 9900502A HU P9900502 A HUP9900502 A HU P9900502A HU P9900502 A2 HUP9900502 A2 HU P9900502A2
Authority
HU
Hungary
Prior art keywords
oxo
pipe powder
methyl
alkyl
formula
Prior art date
Application number
HU9900502A
Other languages
English (en)
Inventor
Stefan Bartel
Werner Hallenbach
Ernst Heinen
Thomas Himmler
Thomas Jaetsch
Franz Pirro
Hans-Georg Rast
Martin Scheer
Michael Stegemann
Hans-Peter Stupp
Heinz-Georg Wetzstein
Original Assignee
Bayer Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19633805A external-priority patent/DE19633805A1/de
Application filed by Bayer Ag. filed Critical Bayer Ag.
Publication of HUP9900502A2 publication Critical patent/HUP9900502A2/hu
Publication of HUP9900502A3 publication Critical patent/HUP9900502A3/hu
Publication of HU228036B1 publication Critical patent/HU228036B1/hu
Priority to HUS1200019C priority Critical patent/HUS1200019I1/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A találmány tárgyát új, (I) általánős képletű, adőtt esetbenhelyettesített 8-cianő-1-ciklőprőpil-7-(2,8-diazabiciklő-[4,3,0]nőnán-8-il)-6-flűőr-1,4-dihidrő-4-őxő-3-kinőlin-karbőnsav-származékők, ezekelőállítási eljárása és a vegyületeket tartalmazó antibakteriáliskészítmények képezik. A képletben R1 jelentése hidrőgénatőm, adőttesetben hidrőxil-, metőxi-, aminő-, metil-aminő- vagy dimetil-aminő-csőpőrttal helyettesített C1-C4 alkil- vagy (5-metil-2-őxő-1,3-diőxől-4-il)-metil-csőpőrt, R2 jelentése hidrőgénatőm, benzil-, C1-C3 alkil-,(5-metil-2-őxő-1,3-diőxől-4-il)-metil-csőpőrt, -CH=CH-COOR3 vagy -CH2-CH2COOR3, általánős képletű csőpőrt, ahől R3 jelentése metil- vagyetilcsőpőrt vagy R4-(NH-CHR5-CO)n- általánős képletű csőpőrt, ahől R4jelentése hidrőgénatőm, C1-C3 alkilcsőpőrt vagy -COO-terc-bűtil-csőpőrt, és R5 jelentése hidrőgénatőm, C1-C4 alkil-, hidrőxi-alkil-,aminő-alkil-, tiő-alkil-, karbőxi-alkil- vagy benzilcsőpőrt, és nértéke 1 vagy 2, vagy a -CH2CH2CN, -CH2CH2COCH3 vagy -CH2COCH3 képletűcsőpőrt, és Y jelentése őxigénatőm vagy kénatőm. ŕ
HU9900502A 1996-02-23 1997-02-12 Optionally substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-[4,3,0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives, process producing them and medicaments thereof HU228036B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HUS1200019C HUS1200019I1 (hu) 1996-02-23 2012-09-21 Adott esetben helyettesített 8-Ciano-1-ciklopropil-7-(2,8-diazabiciklo[4,3,0]nonán-8-il)-6-fluor-1,4-dihidro-4-oxo-3-kinolin-karbonsavak és származékaik, eljárás elõállításukra és ezeket tartalmazó gyógyszerkészítmények

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19606762 1996-02-23
DE19633805A DE19633805A1 (de) 1996-02-23 1996-08-22 Gegenenenfalls substituierte 8-Cyan-l-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren und ihre Derivate
PCT/EP1997/000637 WO1997031001A1 (de) 1996-02-23 1997-02-12 Gegebenenfalls substituierte 8-cyan-1-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren und ihre derivate

Publications (3)

Publication Number Publication Date
HUP9900502A2 true HUP9900502A2 (hu) 1999-06-28
HUP9900502A3 HUP9900502A3 (en) 2000-02-28
HU228036B1 HU228036B1 (en) 2012-08-28

Family

ID=26023165

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900502A HU228036B1 (en) 1996-02-23 1997-02-12 Optionally substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-[4,3,0]-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives, process producing them and medicaments thereof

Country Status (23)

Country Link
US (2) US6323213B1 (hu)
EP (1) EP0882049B1 (hu)
JP (1) JP4338217B2 (hu)
CN (2) CN1073112C (hu)
AT (1) ATE228130T1 (hu)
AU (1) AU715341B2 (hu)
BR (1) BR9707606B1 (hu)
CA (1) CA2247020C (hu)
CZ (1) CZ291251B6 (hu)
DE (1) DE59708771D1 (hu)
DK (1) DK0882049T3 (hu)
ES (1) ES2184060T3 (hu)
HK (1) HK1018903A1 (hu)
HU (1) HU228036B1 (hu)
IL (1) IL125444A (hu)
NO (2) NO311521B1 (hu)
NZ (1) NZ331468A (hu)
PL (1) PL186737B1 (hu)
PT (1) PT882049E (hu)
RU (1) RU2173318C2 (hu)
SK (1) SK284542B6 (hu)
TR (1) TR199801493T2 (hu)
WO (1) WO1997031001A1 (hu)

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DE19717231A1 (de) 1997-04-24 1998-10-29 Bayer Ag 3-Cyano-2,4,5-trifluor-benzoylfluorid
DE19733243A1 (de) 1997-08-01 1999-02-04 Bayer Ag Verfahren zur Herstellung von 3-Cyano-2,4-dihalogen-5-fluor-benzoesäure
DE19826050A1 (de) * 1998-06-12 1999-12-16 Bayer Ag Verfahren zur Herstellung von Chinolon- und Naphthyridoncarbonsäuren und deren Ester
DE19854357A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Semi-Hydrochlorid von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo/4.3.0/ -nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854356A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) * 1998-11-25 2000-05-31 Bayer Ag Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908448A1 (de) * 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure
DE19908449A1 (de) * 1999-02-26 2000-08-31 Bayer Ag Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
DE10224086A1 (de) * 2002-05-31 2003-12-11 Bayer Ag Pharmazeutische Zubereitungen zur oralen Anwendung enthaltend wirkstoffbeladene Ionentauscherharze sowie strukturviskose Gelbildner als Verdicker
DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10337191A1 (de) 2003-08-13 2005-03-17 Bayer Healthcare Ag Neue Verwendung von Chinolon-Antibiotika
US7723524B2 (en) 2003-09-29 2010-05-25 Daiichi Pharmaceutical Co., Ltd. 8-cyanoquinolonecarboxylic acid derivative
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
DE102004015981A1 (de) * 2004-04-01 2005-10-20 Bayer Healthcare Ag Neue kirstalline Form von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
CN1244582C (zh) * 2004-04-21 2006-03-08 中国医学科学院医药生物技术研究所 喹诺酮羧酸类化合物及其制备方法和医药用途
US7759362B2 (en) 2004-04-21 2010-07-20 Institut Of Medicinal Biotechnology Chinese Academy Of Medical Sciences Quinolonecarboxylic acid compounds, preparation methods and pharmaceutical uses thereof
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
DE102006010643A1 (de) * 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
DE102006049520A1 (de) 2006-10-20 2008-04-24 Bayer Healthcare Ag Verfahren zur Herstellung von Pradofloxacin
WO2008059521A2 (en) * 2006-11-14 2008-05-22 Msn Laboratories Limited Novel process for the preparation of moxifloxacin hydrochloride and a novel polymorph of moxifloxacin
CN101020658B (zh) * 2007-02-14 2010-12-15 杭州师范学院 喹诺酮主环化合物的合成方法
DE102007026550A1 (de) 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
DE102007055341A1 (de) 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
EP2429991B1 (en) 2009-05-15 2014-09-10 Redx Pharma Limited Redox drug derivatives
CN102603531B (zh) * 2012-02-22 2014-04-02 仙居县力天化工有限公司 一种串联法制备2,3,4,5-四氟苯甲酸甲酯的方法
JP6228975B2 (ja) * 2012-07-13 2017-11-08 ソルヴェイ（ソシエテ アノニム） 三重結合を有するフッ化カルボニル化合物、その製造方法、及びその使用
WO2018146194A1 (en) 2017-02-13 2018-08-16 Bayer Animal Health Gmbh Liquid composition containing pradofloxacin
CN107987074B (zh) * 2017-10-27 2020-12-29 浙江美诺华药物化学有限公司 一种普拉沙星的合成方法
CA3098060A1 (en) 2018-04-25 2019-10-31 Bayer Animal Health Gmbh Process for the hydrolysis of quinolone carboxylic esters
CN112881542B (zh) * 2020-10-28 2022-11-18 上海安谱实验科技股份有限公司 一种稳定同位素氘标记的达氟沙星及其合成方法
CN114716373B (zh) * 2022-04-14 2023-01-10 内蒙古源宏精细化工有限公司 一种加替沙星环合酯的制备方法

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CA2112165C (en) * 1992-12-25 2003-04-08 Makoto Takemura Bicyclic amine derivatives

Also Published As

Publication number Publication date
IL125444A0 (en) 1999-03-12
AU715341B2 (en) 2000-01-20
DE59708771D1 (de) 2003-01-02
AU1768997A (en) 1997-09-10
JP4338217B2 (ja) 2009-10-07
NO983819L (no) 1998-08-20
CN1335301A (zh) 2002-02-13
HK1018903A1 (en) 2000-01-07
DK0882049T3 (da) 2003-03-03
HU228036B1 (en) 2012-08-28
ES2184060T3 (es) 2003-04-01
NO311521B1 (no) 2001-12-03
US6323213B1 (en) 2001-11-27
EP0882049A1 (de) 1998-12-09
BR9707606B1 (pt) 2010-08-10
CN1073112C (zh) 2001-10-17
WO1997031001A1 (de) 1997-08-28
CA2247020C (en) 2005-11-08
EP0882049B1 (de) 2002-11-20
PL186737B1 (pl) 2004-02-27
SK284542B6 (sk) 2005-06-02
TR199801493T2 (xx) 1998-10-21
ATE228130T1 (de) 2002-12-15
CA2247020A1 (en) 1997-08-28
SK114698A3 (en) 1999-01-11
CZ291251B6 (cs) 2003-01-15
NO983819D0 (no) 1998-08-20
JP2000504734A (ja) 2000-04-18
HUP9900502A3 (en) 2000-02-28
RU2173318C2 (ru) 2001-09-10
US6278013B1 (en) 2001-08-21
CN1211984A (zh) 1999-03-24
PT882049E (pt) 2003-04-30
IL125444A (en) 2001-03-19
BR9707606A (pt) 1999-07-27
CZ268498A3 (cs) 1999-02-17
NO2011022I1 (no) 2011-10-17
NZ331468A (en) 2000-02-28
NO2011022I2 (no) 2013-02-18
PL328577A1 (en) 1999-02-01

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