HUP9801983A2 - Eljárás cisz-4-O-védett-2-ciklopentenol- és ciklopentanolszármazékok előállítására - Google Patents
Eljárás cisz-4-O-védett-2-ciklopentenol- és ciklopentanolszármazékok előállításáraInfo
- Publication number
- HUP9801983A2 HUP9801983A2 HU9801983A HUP9801983A HUP9801983A2 HU P9801983 A2 HUP9801983 A2 HU P9801983A2 HU 9801983 A HU9801983 A HU 9801983A HU P9801983 A HUP9801983 A HU P9801983A HU P9801983 A2 HUP9801983 A2 HU P9801983A2
- Authority
- HU
- Hungary
- Prior art keywords
- powder
- pipe
- pipe powder
- phenyl
- general formula
- Prior art date
Links
- XCIXKGXIYUWCLL-HOSYLAQJSA-N cyclopentanol Chemical class O[13CH]1CCCC1 XCIXKGXIYUWCLL-HOSYLAQJSA-N 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 26
- -1 -CH2OCH2-phenyl Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001743 benzylic group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 2
- 125000005869 (methoxyethoxy)methanyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])* 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000004092 methylthiomethyl group Chemical group [H]C([H])([H])SC([H])([H])* 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány tárgya eljárás a (II) általánős képletű ciszvegyületelőállítására, ahől az általánős képletben Pg jelentése benzilcsőpőrt, szűbsztitűált benzilcsőpőrt, -CH2OCH3csőpőrt, -CH2SCH3 csőpőrt, -CH2OCH2-fenil-csőpőrt, -CH2OCH2CH2OCH3csőpőrt, -CH2OCH2CCl3 csőpőrt, -CH(OCH2CH2Cl)2 csőpőrt, -CH2OCH2CH2Si(CH3)3 csőpőrt, -CH(OC2H5)CH3 csőpőrt, -C(OCH3)(CH3)2csőpőrt, -CH(CH3)OCH(CH3)2 csőpőrt, -CH3CCl3 csőpőrt, -C(CH3)3csőpőrt, -CH2CH=CH2 csőpőrt, -CH2CH=CH-fenil-csőpőrt, -CH(fenil)2csőpőrt, -C(fenil)3 csőpőrt, tetrahidrő-piranil-csőpőrt, 4-metőxi-tetrahidrő-piranil-csőpőrt, 3-bróm-tetrahidrő-piranil-csőpőrt,tetrahidrő-tiőpiranil-csőpőrt, 4-metőxi-tetrahidrő-tiőpiranil-csőpőrt,tetrahidrő-fűranil-csőpőrt, tetrahidrőtiőfű- ranil-csőpőrt, valamintSiR1R2R3 általánős képletű csőpőrt, ahől R1, R2 és R3 mindegyikénekjelentése egymástól függetlenül 1-4 szénatőmős alkilcsőpőrt,fenilcsőpőrt, benzilcsőpőrt, szűbsztitűált fenilcsőpőrt vagyszűbsztitűált benzilcsőpőrt. A találmány szerint úgy járnak el, hőgy az (I) általánős képletűvegyületet, ahől Pg jelentése a kőrábban megadőtt, alkalmas szervesőldószerben őldják, majd az őldatőt alkalmas Lewis-savval és alkalmasredűkálószerrel körülbelül -100 řC - körülbelül 20 řC hőmérsékletenreagáltatják. A találmány tárgyát képezi a (VIb) és (VII) általánős képletűciszvegyületek előállítása is. A találmány szerinti eljárással előállítőtt vegyületekgyógyszerészetben alkalmazható vegyületek intermedierjei. ŕ
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41113695A | 1995-03-27 | 1995-03-27 | |
| US08/588,584 US5728899A (en) | 1995-03-27 | 1996-02-01 | Preparation of cis-4-O-protected-2-cyclopentenol derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9801983A2 true HUP9801983A2 (hu) | 1999-03-29 |
| HUP9801983A3 HUP9801983A3 (en) | 1999-08-30 |
Family
ID=27021289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9801983A HUP9801983A3 (en) | 1995-03-27 | 1996-03-01 | Preparation of cis-4-o-protected-2-cyclopentenol and cyclopentanol derivatives |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5808112A (hu) |
| EP (1) | EP0817764A1 (hu) |
| JP (1) | JPH11502841A (hu) |
| AR (1) | AR001426A1 (hu) |
| AU (1) | AU704196B2 (hu) |
| CA (1) | CA2216245C (hu) |
| HU (1) | HUP9801983A3 (hu) |
| IL (1) | IL117639A0 (hu) |
| NO (1) | NO974458L (hu) |
| NZ (1) | NZ303618A (hu) |
| WO (1) | WO1996030320A1 (hu) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007027189A1 (de) * | 2007-06-13 | 2008-12-18 | Archimica Gmbh | Verfahren zur Herstellung von Cyclopent-4-en-1,3-diol oder Cyclopent-4-en-1,3-diol-Derivaten |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5244896A (en) * | 1990-09-14 | 1993-09-14 | Marion Merrell Dow Inc. | Carbocyclic adenosine analogs useful as immunosuppressants |
-
1996
- 1996-03-01 CA CA002216245A patent/CA2216245C/en not_active Expired - Fee Related
- 1996-03-01 NZ NZ303618A patent/NZ303618A/xx unknown
- 1996-03-01 JP JP8529399A patent/JPH11502841A/ja not_active Abandoned
- 1996-03-01 WO PCT/US1996/002801 patent/WO1996030320A1/en not_active Application Discontinuation
- 1996-03-01 HU HU9801983A patent/HUP9801983A3/hu unknown
- 1996-03-01 AU AU49983/96A patent/AU704196B2/en not_active Ceased
- 1996-03-01 EP EP96906658A patent/EP0817764A1/en not_active Withdrawn
- 1996-03-24 IL IL11763996A patent/IL117639A0/xx not_active IP Right Cessation
- 1996-03-26 AR AR33590696A patent/AR001426A1/es not_active Application Discontinuation
-
1997
- 1997-06-17 US US08/877,364 patent/US5808112A/en not_active Expired - Fee Related
- 1997-09-26 NO NO974458A patent/NO974458L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU704196B2 (en) | 1999-04-15 |
| US5808112A (en) | 1998-09-15 |
| NO974458D0 (no) | 1997-09-26 |
| IL117639A0 (en) | 1996-07-23 |
| NO974458L (no) | 1997-11-27 |
| CA2216245A1 (en) | 1996-10-03 |
| AU4998396A (en) | 1996-10-16 |
| JPH11502841A (ja) | 1999-03-09 |
| HUP9801983A3 (en) | 1999-08-30 |
| MX9707400A (es) | 1997-11-29 |
| CA2216245C (en) | 2002-10-08 |
| AR001426A1 (es) | 1997-10-22 |
| NZ303618A (en) | 1999-03-29 |
| EP0817764A1 (en) | 1998-01-14 |
| WO1996030320A1 (en) | 1996-10-03 |
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