HUP0402661A2 - Készítmény és dózisforma terápiás hatóanyagok szabályozott leadására - Google Patents

Készítmény és dózisforma terápiás hatóanyagok szabályozott leadására

Info

Publication number
HUP0402661A2
HUP0402661A2 HU0402661A HUP0402661A HUP0402661A2 HU P0402661 A2 HUP0402661 A2 HU P0402661A2 HU 0402661 A HU0402661 A HU 0402661A HU P0402661 A HUP0402661 A HU P0402661A HU P0402661 A2 HUP0402661 A2 HU P0402661A2
Authority
HU
Hungary
Prior art keywords
preparation
gastrointestinal system
dosage form
therapeutic agent
preparation according
Prior art date
Application number
HU0402661A
Other languages
English (en)
Inventor
Liang C. Dong
Patrick S. L. Wong
Steve D. Espinal
Vu A. Nguyen
Original Assignee
Alza Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corporation filed Critical Alza Corporation
Publication of HUP0402661A2 publication Critical patent/HUP0402661A2/hu
Publication of HUP0402661A3 publication Critical patent/HUP0402661A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgya egy készítmény és egy szabályozott leadásúdózisforma, amely lehetővé teszi olyan terápiás hatóanyagokszabályozott leadását, amely hatóanyagok csökkent felszívódástmutatnak az alsó gasztrointesztinális rendszerben. A találmányszerinti készítmény olyan terápiás hatóanyagot foglal magában, amelynagyobb felszívódást mutat a felső gasztrointesztinális rendszerben,mint az alsó gasztrointesztinális rendszerben; tartalmaz a készítménytovábbá egy permeációfokozót, amely a terápiás hatóanyagnak az alsógasztrointesztinális rendszerben történő felszívódás növelésétszolgálja. A találmány szerinti készítmény tartalmaz továbbá egyvivőanyagot, amely lehetővé teszi a készítménynek in situ bioadhezívgéllé történő átalakulását, miután a készítmény bekerült agasztrointesztinális rendszerbe és volt lehetősége elérni agasztrointesztinális nyálkamembrán felületét. A találmány szerintikészítmény által képzett bioadhezív gél úgy működik, hogy biztosítjamind a terápiás hatóanyagnak, mind a permeáció-fokozónak effektívkoncentrációi elérését a gasztrointesztinális rendszernyálkamembránjának felületén egy meghatározott időszak alatt. Atalálmány szerinti szabályozott leadású dózisformát úgy alakítjuk ki,hogy a találmány szerinti készítményt kívánt leadási sebességgel vagyleadási sebességprofillal biztosítsa kívánt ideig. Ó
HU0402661A 2001-12-19 2002-12-19 Formulation and dosage form for the controlled delivery of therapeutic agents HUP0402661A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34300101P 2001-12-19 2001-12-19
PCT/US2002/040763 WO2003053400A1 (en) 2001-12-19 2002-12-19 Formulation & dosage form for the controlled delivery of therapeutic agents

Publications (2)

Publication Number Publication Date
HUP0402661A2 true HUP0402661A2 (hu) 2005-07-28
HUP0402661A3 HUP0402661A3 (en) 2008-04-28

Family

ID=23344252

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402661A HUP0402661A3 (en) 2001-12-19 2002-12-19 Formulation and dosage form for the controlled delivery of therapeutic agents

Country Status (14)

Country Link
US (1) US20030232078A1 (hu)
EP (1) EP1458353A1 (hu)
JP (1) JP2005513095A (hu)
KR (1) KR20040090961A (hu)
CN (1) CN1620281A (hu)
AU (1) AU2002357930B2 (hu)
CA (1) CA2471081A1 (hu)
HU (1) HUP0402661A3 (hu)
IL (1) IL162294A0 (hu)
MX (1) MXPA04006025A (hu)
NO (1) NO20042993L (hu)
NZ (1) NZ533062A (hu)
WO (1) WO2003053400A1 (hu)
ZA (1) ZA200405657B (hu)

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Also Published As

Publication number Publication date
IL162294A0 (en) 2005-11-20
AU2002357930B2 (en) 2007-06-28
EP1458353A1 (en) 2004-09-22
WO2003053400A1 (en) 2003-07-03
HUP0402661A3 (en) 2008-04-28
KR20040090961A (ko) 2004-10-27
MXPA04006025A (es) 2005-03-31
NZ533062A (en) 2006-03-31
NO20042993L (no) 2004-09-20
AU2002357930A1 (en) 2003-07-09
CA2471081A1 (en) 2003-07-03
CN1620281A (zh) 2005-05-25
ZA200405657B (en) 2005-08-29
JP2005513095A (ja) 2005-05-12
US20030232078A1 (en) 2003-12-18

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