HUP0401386A2 - Kationos dextránszármazékok alkalmazása dóziskorlátozó szervek védelmére alkalmas gyógyszerkészítmények előállítására - Google Patents

Kationos dextránszármazékok alkalmazása dóziskorlátozó szervek védelmére alkalmas gyógyszerkészítmények előállítására

Info

Publication number
HUP0401386A2
HUP0401386A2 HU0401386A HUP0401386A HUP0401386A2 HU P0401386 A2 HUP0401386 A2 HU P0401386A2 HU 0401386 A HU0401386 A HU 0401386A HU P0401386 A HUP0401386 A HU P0401386A HU P0401386 A2 HUP0401386 A2 HU P0401386A2
Authority
HU
Hungary
Prior art keywords
radioactive
pharmaceutical compositions
dose
preparation
limiting
Prior art date
Application number
HU0401386A
Other languages
English (en)
Inventor
Anders Holmberg
Jukka Hiltunen
Giovanni Paganelli
Marta Cremonesi
Original Assignee
Map Medical Technologies Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Map Medical Technologies Oy filed Critical Map Medical Technologies Oy
Publication of HUP0401386A2 publication Critical patent/HUP0401386A2/hu
Publication of HUP0401386A3 publication Critical patent/HUP0401386A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya kationos dextránszármazék alkalmazása gyógyászatikompozíciók előállítására, amelyek a dóziskorlátozó szereket megvédika szisztémás kezelés folyamán. A találmány része továbbá az eljárás aszisztémás kezelés során a dóziskorlátozó szervekben a radioaktív vagycitotoxikus ágensek okozta károsodások kivédésére. Az eljárás magábanfoglalja valamely pozitív töltésű kationos oldallánccsoportokkalrendelkező dextránszármazék hatékony mennyiségének alkalmazását akemoterápiás, radioaktív vagy immunszupresszív ágens alkalmazásátmegelőzően vagy ahhoz kapcsolódóan. A találmányhoz tartozik még azeljárás a rák szisztémás kezelése során a citotoxikus vagy radioaktívágensek nefrotoxikus hatásai által okozott vesekárosodás kivédésére.Az eljárás magában foglalja valamely pozitív töltésű kationosoldallánccsoportokkal rendelkező dextránszármazék a vesék megvédésérealkalmas mennyiségének alkalmazását a kemoterápiás, radioaktív vagyimmunszupresszív ágens alkalmazását megelőzően vagy ahhozkapcsolódóan. Ó
HU0401386A 2001-04-11 2002-04-11 Use of cationic dextran derivatives for preparation of pharmaceutical compositions protecting dose-limiting organs HUP0401386A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20010764A FI20010764A0 (fi) 2001-04-11 2001-04-11 Kationiset dekstraanijohdannaiset käytettäväksi munuaisten suojaamiseen
PCT/FI2002/000305 WO2002083154A1 (en) 2001-04-11 2002-04-11 Use of cationic dextran derivatives for protecting dose-limiting organs

Publications (2)

Publication Number Publication Date
HUP0401386A2 true HUP0401386A2 (hu) 2004-12-28
HUP0401386A3 HUP0401386A3 (en) 2005-06-28

Family

ID=8560975

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0401386A HUP0401386A3 (en) 2001-04-11 2002-04-11 Use of cationic dextran derivatives for preparation of pharmaceutical compositions protecting dose-limiting organs

Country Status (13)

Country Link
EP (1) EP1383517A1 (hu)
JP (1) JP2004525181A (hu)
KR (1) KR20040018350A (hu)
BR (1) BR0208860A (hu)
CA (1) CA2443052A1 (hu)
EE (1) EE200300502A (hu)
FI (1) FI20010764A0 (hu)
HU (1) HUP0401386A3 (hu)
IL (1) IL158153A0 (hu)
NO (1) NO20034561L (hu)
PL (1) PL363024A1 (hu)
RU (1) RU2003132683A (hu)
WO (1) WO2002083154A1 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010102066A1 (en) 2009-03-05 2010-09-10 Bend Research, Inc. Dextran polymer powder for inhalation administration of pharmaceuticals
EP3130396B1 (en) 2009-03-27 2021-03-17 Bend Research, Inc. Spray-drying process
WO2012031129A2 (en) 2010-09-03 2012-03-08 Bend Research, Inc. Spray-drying apparatus and methods of using the same
PT2611530T (pt) 2010-09-03 2019-05-09 Bend Res Inc Aparelho de secagem por pulverização e métodos de utilização do mesmo
US8815294B2 (en) 2010-09-03 2014-08-26 Bend Research, Inc. Pharmaceutical compositions of dextran polymer derivatives and a carrier material
EP2618924A1 (en) 2010-09-24 2013-07-31 Bend Research, Inc. High-temperature spray drying process and apparatus
US9060938B2 (en) 2011-05-10 2015-06-23 Bend Research, Inc. Pharmaceutical compositions of active agents and cationic dextran polymer derivatives
DE102014016901B4 (de) * 2014-09-17 2021-08-12 Friedrich-Schiller-Universität Jena Verfahren zur Herstellung für neue Dextranderivate als Wirkstoffträgersystem und deren Verwendung
CA3044891A1 (en) * 2016-12-01 2018-06-07 Norbert Gretz Means and methods for visualization of tissue structures
BR112022011800A2 (pt) * 2019-12-14 2022-08-30 Chaudhary Manu Formulações de fármacos polibásicos para reduzir a toxicidade de múltiplos órgãos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3414491A1 (de) * 1984-04-17 1985-10-24 Hans Dr. 8202 Bad Aibling Dietl L-aminosaeurengemische fuer die parenterale und orale anwendung bei nierenerkrankungen
US5290538A (en) * 1988-12-22 1994-03-01 Skrezek Christian Nephro protective infusion solutions
SE9803482D0 (sv) * 1998-10-13 1998-10-13 Anders Holmberg Ion exchange tumor targeting (IETT)
AU6275800A (en) * 1999-07-16 2001-02-05 Mallinckrodt, Inc. Inhibition of renal uptake of molecules that are potentially damaging for the kidney

Also Published As

Publication number Publication date
CA2443052A1 (en) 2002-10-24
EE200300502A (et) 2003-12-15
BR0208860A (pt) 2004-10-19
HUP0401386A3 (en) 2005-06-28
FI20010764A0 (fi) 2001-04-11
RU2003132683A (ru) 2005-04-10
EP1383517A1 (en) 2004-01-28
NO20034561D0 (no) 2003-10-10
KR20040018350A (ko) 2004-03-03
JP2004525181A (ja) 2004-08-19
WO2002083154A1 (en) 2002-10-24
NO20034561L (no) 2003-12-09
PL363024A1 (en) 2004-11-15
IL158153A0 (en) 2004-03-28

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