HUP0401283A2 - Annellált pirrolvegyületek alkalmazása ízületi porc vagy porc melletti csont elfajulásának kezelésére, és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Annellált pirrolvegyületek alkalmazása ízületi porc vagy porc melletti csont elfajulásának kezelésére, és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0401283A2 HUP0401283A2 HU0401283A HUP0401283A HUP0401283A2 HU P0401283 A2 HUP0401283 A2 HU P0401283A2 HU 0401283 A HU0401283 A HU 0401283A HU P0401283 A HUP0401283 A HU P0401283A HU P0401283 A2 HUP0401283 A2 HU P0401283A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- formula
- aromatic
- general formula
- treatment
- Prior art date
Links
- 210000001188 articular cartilage Anatomy 0.000 title abstract 2
- 230000007850 degeneration Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003233 pyrroles Chemical class 0.000 title 1
- 210000005065 subchondral bone plate Anatomy 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 241000124008 Mammalia Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- IQUPABOKLQSFBK-UHFFFAOYSA-N 2-nitrophenol Chemical compound OC1=CC=CC=C1[N+]([O-])=O IQUPABOKLQSFBK-UHFFFAOYSA-N 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány emlősök ízületi porca és/vagy porc melletti csontjadegenerálódásának vagy destrukciójának kezelésére vagy megelőzéséreszolgáló eljárással foglalkozik, mely eljárás abból áll, hogy akezelendő emlős szervezetébe az (I) általános képletű vegyületnek,gyógyászatilag alkalmazható sójának vagy fiziológiásan hidrolizálhatóészterének terápiásan hatásos mennyiségét juttatják. Előnyös (I)általános képletű vegyület az (la) képletű[6-(4-klór-fenil)-2,2-dimetil-7-fenil-2,3-dihidroxi-1 H-pirrolizini-5-il]-ecetsav (ML3000).Az (I) általános képletben X jelentése CR8R9 általános képletűcsoport, kén- vagy nitrogénatom, NR12 általános képletű csoport vagyC(O); A jelentése CR10R11 általános képletű csoport vagy kötés; R1jelentése adott esetben helyettesített aril-, aromás vagy nem aromásegy vagy kétgyűrűs 1,2 heteroaromot tartalmazó heterociklusos csoport;R2 jelentése adott esetben helyettesített alkil-, cikloalkil-, aril-vagy aromás vagy nem aromás egy vagy kétgyűrűs heterociklusos csoport;R3 jelentése hidrogén- vagy halogénatom, alkil-, HO-alkil-, CHO-,COOH- képletű csoport; B-Y-csoport - ahol B jelentése alkilén- vagyalkenilén csoport, Y jelentése -COOH, SO3H, OPO(OH)2, OP(OH)2-CHO-képletű csoport. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31577301P | 2001-08-30 | 2001-08-30 | |
CA002356099A CA2356099A1 (en) | 2001-08-30 | 2001-08-30 | Use of annellated pyrrole compounds in the treatment of articular cartilage or subchondral bone degeneration |
PCT/EP2002/009658 WO2003020267A1 (en) | 2001-08-30 | 2002-08-29 | Use of annellated pyrrole compounds in the treatment of articular cartilage or subchondral bone degeneration |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0401283A2 true HUP0401283A2 (hu) | 2004-12-28 |
Family
ID=25682702
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0401283A HUP0401283A2 (hu) | 2001-08-30 | 2002-08-29 | Annellált pirrolvegyületek alkalmazása ízületi porc vagy porc melletti csont elfajulásának kezelésére, és ezeket tartalmazó gyógyszerkészítmények |
Country Status (11)
Country | Link |
---|---|
US (1) | US7425573B2 (hu) |
EP (1) | EP1427410A1 (hu) |
JP (1) | JP2005504781A (hu) |
CN (1) | CN1549711A (hu) |
BR (1) | BR0212244A (hu) |
HU (1) | HUP0401283A2 (hu) |
IS (1) | IS7166A (hu) |
MX (1) | MXPA04001868A (hu) |
NZ (1) | NZ531226A (hu) |
RU (1) | RU2303447C2 (hu) |
WO (1) | WO2003020267A1 (hu) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060040945A1 (en) * | 2002-05-17 | 2006-02-23 | Merckle Gmbh | Annellated pyrrole compounds as proton pump inhibitors for treating ulcer |
US20050129764A1 (en) * | 2003-12-11 | 2005-06-16 | Vergez Juan A. | Osmotic device containing licofelone |
WO2005123130A2 (en) * | 2004-06-17 | 2005-12-29 | Osteologix A/S | Improved treatments of rheumatic and arthritic diseases comprising combinations of a 5-lipoxygenase inhibitor |
CA2619608C (en) * | 2005-08-18 | 2016-02-02 | Accelalox, Inc. | Methods for bone treatment by modulating an arachidonic acid metabolic or signaling pathway |
EP1891955A1 (en) * | 2006-07-24 | 2008-02-27 | Sanofi-Aventis | Use of 1,2,3-substituted indolizine derivatives, inhibitors of FGFs, for the preparation of a medicament intended for the treatment of degenerative joint diseases |
EP1884239A1 (en) * | 2006-07-28 | 2008-02-06 | Merckle Gmbh | Annellated pyrrole compounds for cancer management |
NZ592378A (en) * | 2008-10-31 | 2012-09-28 | C A I R Biosciences Gmbh | Choline and tromethamine salt of licofelone |
CA2822357A1 (en) | 2010-12-22 | 2012-06-28 | Abbvie Inc. | Hepatitis c inhibitors and uses thereof |
US8524662B2 (en) | 2010-12-28 | 2013-09-03 | Depuy Mitek, Llc | Compositions and methods for treating joints |
US8398611B2 (en) | 2010-12-28 | 2013-03-19 | Depuy Mitek, Inc. | Compositions and methods for treating joints |
US8455436B2 (en) | 2010-12-28 | 2013-06-04 | Depuy Mitek, Llc | Compositions and methods for treating joints |
US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
WO2016201682A1 (zh) * | 2015-06-18 | 2016-12-22 | 高雄医学大学 | 一种医药组合物用于制备促进软骨细胞生成的药物的用途 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4232038A (en) * | 1979-08-31 | 1980-11-04 | Syntex (U.S.A.) Inc. | 5-Alkylsulfinylbenzoyl- and 5-alkylsulfonylbenzoyl-1,2-dihydro-3H-pyrrolo[1,]pyrrole-1-carboxylic acids |
US4704356A (en) * | 1984-03-27 | 1987-11-03 | Rush-Presbyterian-St. Luke's Medical Center | Method of diagnosing cartilage tissue abnormalities |
US5260451A (en) * | 1989-05-11 | 1993-11-09 | Merckle Gmbh | Substituted pyrrole compounds and use thereof in pharmaceutical compositions |
US5095037B1 (en) * | 1989-12-21 | 1995-12-19 | Nissho Kk | Combined anti-inflammatory agent |
US5464609A (en) * | 1990-03-16 | 1995-11-07 | The Procter & Gamble Company | Use of ketorolac for treatment of oral diseases and conditions |
US5310759A (en) * | 1992-08-12 | 1994-05-10 | Bockman Richard S | Methods of protecting and preserving connective and support tissues |
DE4419247A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Sulfonylierte Pyrrolizincarbonsäureamide und deren Anwendung in der Pharmazie |
DE4419315A1 (de) | 1994-06-01 | 1995-12-07 | Merckle Gmbh | Heteropyrrolizinverbindungen und deren Anwendung in der Pharmazie |
DE19624290A1 (de) | 1996-06-18 | 1998-01-02 | Merckle Gmbh | Verwendungen von Pyrrolizin-Verbindungen in der Pharmazie |
DE19624289A1 (de) | 1996-06-18 | 1998-01-02 | Merckle Gmbh | Pyrrolizin-Verbindungen und deren Verwendung |
DE19845446A1 (de) | 1998-10-02 | 2000-04-06 | Merckle Gmbh | Antiinflammatorische Oxo- und Hydroxyderivate von Pyrrolizinen und deren Verwendung in der Pharmazie |
DK1232158T3 (da) | 1999-11-23 | 2004-06-14 | Merckle Gmbh | Anti-inflammatoriske oxo- og hydroxyderivater af pyrroliziner og anvendelse deraf på det farmaceutiske område |
DE10001166A1 (de) * | 2000-01-13 | 2001-07-19 | Merckle Gmbh | Anellierte Pyrrolverbindungen, diese enthaltende pharmazeutische Mittel und deren Verwendung |
DE10004157A1 (de) * | 2000-02-01 | 2001-08-02 | Merckle Gmbh Chem Pharm Fabrik | 4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie |
-
2002
- 2002-08-29 RU RU2004109227/15A patent/RU2303447C2/ru not_active IP Right Cessation
- 2002-08-29 HU HU0401283A patent/HUP0401283A2/hu unknown
- 2002-08-29 BR BR0212244-8A patent/BR0212244A/pt not_active IP Right Cessation
- 2002-08-29 WO PCT/EP2002/009658 patent/WO2003020267A1/en active IP Right Grant
- 2002-08-29 CN CNA028170806A patent/CN1549711A/zh active Pending
- 2002-08-29 EP EP02797552A patent/EP1427410A1/en not_active Withdrawn
- 2002-08-29 NZ NZ531226A patent/NZ531226A/en unknown
- 2002-08-29 JP JP2003524574A patent/JP2005504781A/ja active Pending
- 2002-08-29 MX MXPA04001868A patent/MXPA04001868A/es active IP Right Grant
- 2002-08-29 US US10/486,912 patent/US7425573B2/en not_active Expired - Fee Related
-
2004
- 2004-02-27 IS IS7166A patent/IS7166A/is unknown
Also Published As
Publication number | Publication date |
---|---|
IS7166A (is) | 2004-02-27 |
WO2003020267A1 (en) | 2003-03-13 |
RU2303447C2 (ru) | 2007-07-27 |
JP2005504781A (ja) | 2005-02-17 |
RU2004109227A (ru) | 2005-04-10 |
US7425573B2 (en) | 2008-09-16 |
MXPA04001868A (es) | 2005-10-05 |
US20050004108A1 (en) | 2005-01-06 |
NZ531226A (en) | 2006-07-28 |
BR0212244A (pt) | 2004-10-05 |
CN1549711A (zh) | 2004-11-24 |
EP1427410A1 (en) | 2004-06-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |