HUP0400928A1 - Ginkgo biloba extraktumok alkalmazása sarcopenia kezelésére használható gyógyszer elõállítására - Google Patents
Ginkgo biloba extraktumok alkalmazása sarcopenia kezelésére használható gyógyszer elõállításáraInfo
- Publication number
- HUP0400928A1 HUP0400928A1 HU0400928A HUP0400928A HUP0400928A1 HU P0400928 A1 HUP0400928 A1 HU P0400928A1 HU 0400928 A HU0400928 A HU 0400928A HU P0400928 A HUP0400928 A HU P0400928A HU P0400928 A1 HUP0400928 A1 HU P0400928A1
- Authority
- HU
- Hungary
- Prior art keywords
- ginkgolide
- ginkgo biloba
- version
- group
- sarcopenia
- Prior art date
Links
- 235000020686 ginkgo biloba extract Nutrition 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title abstract 3
- 208000001076 sarcopenia Diseases 0.000 title abstract 3
- SQOJOAFXDQDRGF-WJHVHIKBSA-N ginkgolide B Natural products O=C1[C@@H](C)[C@@]2(O)[C@@H]([C@H](O)[C@]34[C@@H]5OC(=O)[C@]23O[C@H]2OC(=O)[C@H](O)[C@@]42[C@H](C(C)(C)C)C5)O1 SQOJOAFXDQDRGF-WJHVHIKBSA-N 0.000 abstract 6
- MOLPUWBMSBJXER-YDGSQGCISA-N bilobalide Chemical compound O([C@H]1OC2=O)C(=O)[C@H](O)[C@@]11[C@@](C(C)(C)C)(O)C[C@H]3[C@@]21CC(=O)O3 MOLPUWBMSBJXER-YDGSQGCISA-N 0.000 abstract 4
- 229930184727 ginkgolide Natural products 0.000 abstract 4
- 239000009429 Ginkgo biloba extract Substances 0.000 abstract 3
- AMOGMTLMADGEOQ-FNZROXQESA-N Ginkgolide C Chemical compound O([C@H]1O2)C(=O)[C@H](O)C31[C@]14[C@@H](O)[C@@H]5OC(=O)[C@@H](C)[C@]5(O)[C@@]12C(=O)O[C@@H]4[C@@H](O)[C@H]3C(C)(C)C AMOGMTLMADGEOQ-FNZROXQESA-N 0.000 abstract 3
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 abstract 3
- 229930003944 flavone Natural products 0.000 abstract 3
- -1 flavone glycosides Chemical class 0.000 abstract 3
- 235000011949 flavones Nutrition 0.000 abstract 3
- 229940068052 ginkgo biloba extract Drugs 0.000 abstract 3
- FPUXKXIZEIDQKW-MFJLLLFKSA-N ginkgolide A Natural products O=C1[C@H](C)[C@@]2(O)[C@@H](O1)C[C@]13[C@@H]4OC(=O)[C@]21O[C@@H]1OC(=O)[C@H](O)[C@]31[C@@H](C(C)(C)C)C4 FPUXKXIZEIDQKW-MFJLLLFKSA-N 0.000 abstract 3
- AMOGMTLMADGEOQ-DPFZUGDXSA-N ginkgolide C Natural products O=C1[C@@H](C)[C@]2(O)[C@H]([C@H](O)[C@@]34[C@H]5[C@H](O)[C@@H](C(C)(C)C)[C@]63[C@H](O)C(=O)O[C@H]6O[C@@]24C(=O)O5)O1 AMOGMTLMADGEOQ-DPFZUGDXSA-N 0.000 abstract 3
- LMEHVEUFNRJAAV-HOSIAMDISA-N ginkgolide J Natural products O=C1[C@H](C)[C@@]2(O)[C@H](O1)C[C@@]13[C@H]4[C@@H](O)[C@@H](C(C)(C)C)[C@@]51[C@@H](O)C(=O)O[C@@H]5O[C@@]23C(=O)O4 LMEHVEUFNRJAAV-HOSIAMDISA-N 0.000 abstract 3
- FPUXKXIZEIDQKW-VKMVSBOZSA-N ginkgolide-a Chemical compound O[C@H]([C@]12[C@H](C(C)(C)C)C[C@H]3OC4=O)C(=O)O[C@H]2O[C@]24[C@@]13C[C@@H]1OC(=O)[C@@H](C)[C@]21O FPUXKXIZEIDQKW-VKMVSBOZSA-N 0.000 abstract 3
- SQOJOAFXDQDRGF-MMQTXUMRSA-N ginkgolide-b Chemical compound O[C@H]([C@]12[C@H](C(C)(C)C)C[C@H]3OC4=O)C(=O)O[C@H]2O[C@]24[C@@]13[C@@H](O)[C@@H]1OC(=O)[C@@H](C)[C@]21O SQOJOAFXDQDRGF-MMQTXUMRSA-N 0.000 abstract 3
- LMEHVEUFNRJAAV-UKWFQYJJSA-N ginkgolide-j Chemical compound O([C@H]1O2)C(=O)[C@H](O)[C@@]31[C@]14C[C@@H]5OC(=O)[C@@H](C)[C@]5(O)[C@@]12C(=O)O[C@@H]4[C@H](O)[C@H]3C(C)(C)C LMEHVEUFNRJAAV-UKWFQYJJSA-N 0.000 abstract 3
- 229930182470 glycoside Natural products 0.000 abstract 3
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- JPFCOVZKLAXXOE-XBNSMERZSA-N (3r)-2-(3,5-dihydroxy-4-methoxyphenyl)-8-[(2r,3r,4r)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]-3,4-dihydro-2h-chromene-3,5,7-triol Chemical compound C1=C(O)C(OC)=C(O)C=C1C1[C@H](O)CC(C(O)=CC(O)=C2[C@H]3C4=C(O)C=C(O)C=C4O[C@@H]([C@@H]3O)C=3C=CC(O)=CC=3)=C2O1 JPFCOVZKLAXXOE-XBNSMERZSA-N 0.000 abstract 1
- 229920001991 Proanthocyanidin Polymers 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000002016 disaccharides Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A találmány a Ginkgo biloba extraktumainak alkalmazására vonatkozik,olyan gyógyszer előállításában, amely alkalmas a sarcopenia (az izomtömegének lecsökkenésével járó időskori betegség) megelőzésére vagykifejlődésének lelassítására. A találmány tárgya legalább flavon-glikozidokat és/vagy ginkgolidot vagy ginkgolidokat tartalmazó Ginkgobiloba extraktum alkalmazása sarcopenia megelőzésére vagy kezelésérehasználható gyógyszerek előállítására. A találmány egyik változataszerint a Ginkgo biloba extraktum 20-30% flavon-glikozidot, összesen2,5-4,5% ginkgolid A-t, B-t C-t és J-t, 2-4% bilobalidot, 10%-nálkevesebb proantocianidint, és 10 ppm-nél kisebb mennyiségű alkilfenoltípusú vegyületet tartalmaz. A találmány másik változata szerint aGinkgo biloba extraktum összesen 5,5-8% ginkgolid A-t, B-t, C-t és J-t, 40-60% flavon-glikozidot és 5-7% bilobalidot tartalmaz. Adottesetben a ginkgolid vagy a ginkgolidok helyettesíthetők acetizelett,alkoxilezett vagy glikozilezett homológjaikkal. Ennek megfelelően atalálmány harmadik változata szerint a ginkgolid A, B, C és J legalábbegy része (I) általános képletű vegyületekkel van helyettesítve,amelyek képletében W, X, Y és Z egymástól függetlenül hidrogénatomotvagy hidroxilcsoportot, egyenes vagy elágazó láncú alkoxicsoportotvagy GS-OH mono- vagy diszacharidoknak vagy azok egy származékánakvagy analógjának megfelelő -O-GS csoportot jelent, azzal a kikötéssel,hogy W, X, Y és Z közül legalább az egyik -O-GS csoport. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0109506A FR2827518B1 (fr) | 2001-07-17 | 2001-07-17 | Utilisation d'extraits de ginkgo biloba pour preparer un medicament destine a traiter la sarcopenie |
| PCT/FR2002/002519 WO2003007973A1 (fr) | 2001-07-17 | 2002-07-16 | Utilisation d'extraits de ginkgo biloba pour preparer un medicament destine a traiter la sarcopenie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0400928A1 true HUP0400928A1 (hu) | 2004-07-28 |
| HUP0400928A3 HUP0400928A3 (en) | 2008-04-28 |
Family
ID=8865590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0400928A HUP0400928A3 (en) | 2001-07-17 | 2002-07-16 | Use of ginkgo biloba extracts for preparing a medicine for treating sarcopenia |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7138148B2 (hu) |
| EP (1) | EP1411961B1 (hu) |
| JP (1) | JP4510445B2 (hu) |
| KR (1) | KR100891393B1 (hu) |
| CN (1) | CN1272016C (hu) |
| AT (1) | ATE304861T1 (hu) |
| AU (1) | AU2002334001B2 (hu) |
| CA (1) | CA2453254C (hu) |
| DE (1) | DE60206280T2 (hu) |
| DK (1) | DK1411961T3 (hu) |
| ES (1) | ES2250726T3 (hu) |
| FR (1) | FR2827518B1 (hu) |
| HK (1) | HK1069327A1 (hu) |
| HU (1) | HUP0400928A3 (hu) |
| NZ (1) | NZ530367A (hu) |
| PL (1) | PL202567B1 (hu) |
| RU (1) | RU2298411C2 (hu) |
| WO (1) | WO2003007973A1 (hu) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2842425B1 (fr) | 2002-07-16 | 2005-04-08 | Sod Conseils Rech Applic | Utilisation d'extraits de ginkgo biloba pour favoriser la masse musculaire au detriment de la masse graisseuse |
| US8058211B2 (en) * | 2007-12-12 | 2011-11-15 | Halliburton Energy Services, Inc. | Corrosion inhibitor intensifier compositions and associated methods |
| IN2012DN06588A (hu) | 2010-02-10 | 2015-10-23 | Novartis Ag | |
| US9029558B2 (en) | 2011-08-18 | 2015-05-12 | Semiconductor Energy Laboratory Co., Ltd. | Carbazole compound, light-emitting element, light-emitting device, electronic device, and lighting device |
| KR102051433B1 (ko) | 2013-08-27 | 2020-01-08 | (주)네오팜 | 근육 분화 촉진 및 근육 강화용 조성물 및 외용제 |
| KR101771486B1 (ko) | 2015-06-25 | 2017-08-25 | 서울대학교산학협력단 | 특정 다마란 계열의 성분이 증가된 인삼추출물의 제조방법 및 이를 이용한 근육감소증 관련 질환 치료용 조성물 |
| KR102281263B1 (ko) | 2019-03-12 | 2021-07-26 | 주식회사 비티씨 | 갈릭산, 에피카테킨(ec), 및 에피갈로카테킨(egc)의 함량이 증가된 카테킨 효소처리물 및 이의 제조방법 |
| CN113840536A (zh) | 2019-05-31 | 2021-12-24 | 雀巢产品有限公司 | 用于在动物中提供健康有益效果的基于mct的营养共混物 |
| KR102229177B1 (ko) | 2019-12-27 | 2021-03-18 | 부산대학교 산학협력단 | 로즈마리 추출물 및 대두 추출물을 유효성분으로 함유하는 근육 감소증 예방 또는 치료용 조성물 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3338995A1 (de) * | 1983-10-27 | 1985-05-09 | Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe | Bilobalid enthaltende arzneimittel |
| WO1998000024A1 (en) * | 1996-06-28 | 1998-01-08 | Viva America Marketing, Inc. | Nutritional supplement composition and use |
| FR2763592B1 (fr) * | 1997-05-20 | 1999-07-16 | Sod Conseils Rech Applic | Nouveaux derives glycosyles des ginkgolides, leur application en tant que medicaments et compositions pharmaceutiques les contenant |
| JP3293524B2 (ja) * | 1997-06-17 | 2002-06-17 | 有限会社薬研 | イチョウ葉抽出エキス担持粉体複合物及びその製造方法 |
| FR2771639B1 (fr) * | 1997-12-03 | 2000-05-05 | Sod Conseils Rech Applic | Utilisation d'extraits de ginkgo biloba pour preparer un medicament destine a faciliter le sevrage d'individus dependants de la consommation d'une substance engendrant une dependance et/ou une addiction |
| US6030621A (en) * | 1998-03-19 | 2000-02-29 | De Long; Xie | Ginkgo biloba composition, method to prepare the same and uses thereof |
| FR2782008B1 (fr) * | 1998-08-07 | 2003-04-25 | Sod Conseils Rech Applic | Utilisation d'extraits de ginkgo biloba pour preparer un medicament destine a traiter la sclerose laterale amyotrophique |
-
2001
- 2001-07-17 FR FR0109506A patent/FR2827518B1/fr not_active Expired - Fee Related
-
2002
- 2002-07-16 WO PCT/FR2002/002519 patent/WO2003007973A1/fr active IP Right Grant
- 2002-07-16 CN CNB028143663A patent/CN1272016C/zh not_active Expired - Fee Related
- 2002-07-16 PL PL367089A patent/PL202567B1/pl unknown
- 2002-07-16 KR KR1020047000669A patent/KR100891393B1/ko not_active IP Right Cessation
- 2002-07-16 JP JP2003513578A patent/JP4510445B2/ja not_active Expired - Fee Related
- 2002-07-16 AT AT02787156T patent/ATE304861T1/de active
- 2002-07-16 RU RU2004104463/15A patent/RU2298411C2/ru not_active IP Right Cessation
- 2002-07-16 DE DE60206280T patent/DE60206280T2/de not_active Expired - Lifetime
- 2002-07-16 US US10/481,953 patent/US7138148B2/en not_active Expired - Fee Related
- 2002-07-16 DK DK02787156T patent/DK1411961T3/da active
- 2002-07-16 AU AU2002334001A patent/AU2002334001B2/en not_active Ceased
- 2002-07-16 HU HU0400928A patent/HUP0400928A3/hu unknown
- 2002-07-16 CA CA2453254A patent/CA2453254C/fr not_active Expired - Fee Related
- 2002-07-16 ES ES02787156T patent/ES2250726T3/es not_active Expired - Lifetime
- 2002-07-16 EP EP02787156A patent/EP1411961B1/fr not_active Expired - Lifetime
- 2002-07-16 NZ NZ530367A patent/NZ530367A/en not_active IP Right Cessation
-
2005
- 2005-03-07 HK HK05101935A patent/HK1069327A1/xx not_active IP Right Cessation
-
2006
- 2006-01-12 US US11/330,767 patent/US7232580B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL367089A1 (en) | 2005-02-21 |
| AU2002334001B2 (en) | 2007-07-19 |
| EP1411961A1 (fr) | 2004-04-28 |
| DK1411961T3 (da) | 2006-02-06 |
| RU2004104463A (ru) | 2005-06-10 |
| US7138148B2 (en) | 2006-11-21 |
| FR2827518B1 (fr) | 2005-07-08 |
| CA2453254C (fr) | 2011-02-15 |
| WO2003007973A1 (fr) | 2003-01-30 |
| KR100891393B1 (ko) | 2009-04-02 |
| EP1411961B1 (fr) | 2005-09-21 |
| US7232580B2 (en) | 2007-06-19 |
| DE60206280D1 (de) | 2006-02-02 |
| FR2827518A1 (fr) | 2003-01-24 |
| CN1533281A (zh) | 2004-09-29 |
| CN1272016C (zh) | 2006-08-30 |
| RU2298411C2 (ru) | 2007-05-10 |
| HUP0400928A3 (en) | 2008-04-28 |
| PL202567B1 (pl) | 2009-07-31 |
| JP4510445B2 (ja) | 2010-07-21 |
| DE60206280T2 (de) | 2006-07-27 |
| KR20040013150A (ko) | 2004-02-11 |
| US20040166180A1 (en) | 2004-08-26 |
| CA2453254A1 (fr) | 2003-01-30 |
| NZ530367A (en) | 2006-05-26 |
| JP2005512956A (ja) | 2005-05-12 |
| HK1069327A1 (en) | 2005-05-20 |
| ATE304861T1 (de) | 2005-10-15 |
| US20060121135A1 (en) | 2006-06-08 |
| ES2250726T3 (es) | 2006-04-16 |
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