HUP0400341A2 - Ciano-szubsztituált dihidropirimidin-vegyületek és alkalmazásuk - Google Patents

Ciano-szubsztituált dihidropirimidin-vegyületek és alkalmazásuk

Info

Publication number
HUP0400341A2
HUP0400341A2 HU0400341A HUP0400341A HUP0400341A2 HU P0400341 A2 HUP0400341 A2 HU P0400341A2 HU 0400341 A HU0400341 A HU 0400341A HU P0400341 A HUP0400341 A HU P0400341A HU P0400341 A2 HUP0400341 A2 HU P0400341A2
Authority
HU
Hungary
Prior art keywords
alkyl
cyano
hydrogen
arylalkyl
heteroarylalkyl
Prior art date
Application number
HU0400341A
Other languages
English (en)
Inventor
Louis J. Lombardo
Laurence I. Wu
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HUP0400341A2 publication Critical patent/HUP0400341A2/hu
Publication of HUP0400341A3 publication Critical patent/HUP0400341A3/hu

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
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  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
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Abstract

A találmány tárgyát az általános képletű vegyületek - ahol R1hidrogén, alkil-, cikloalkilcsoport; R4 alkil-, aril-alkil-,cikloalkil-alkil-, heteroaril-alkil-, heterocikloalkil-alkil-, ciano-vagy acil-, észter- vagy szubsztitált karboxamido-csoport; Y1, Y2, Y3,Y4 és Y5 egymástól függetlenül hidrogén-, halogénatom, alkil-,alkoxi-, aril-oxi- vagy szubsztituált aminocsoport; Z oxigén-, kénatomvagy =N-R8; R8 hidrogénatom, ciano-, szulfonamido-, -OR7, alkil-,cikloalkil-, aril-, aril-alkil-, heterociklil-, heteroaril- vagyheteroaril-alkil-csoport; és R7 hidrogénatom, alkil-, aril-alkil-,ciloalkil-alkil-, heterocikloalkil-alkil- vagy heteroaril-alkil-csoport és enantiomereik, diasztereomereik, gyógyszerészetilegelfogadható sóik, prodrugjaik és szolvátjaik, valamint alkalmazásuk amitózis megszakításának kiváltásával sejtburjánzást gátló betegségekkezelésére szolgáló gyógyszerkészítmények előállítására valóalkalmazásuk képezik. Ó
HU0400341A 2001-03-29 2002-03-26 Cyano-substituted dihydropyrimidine compounds and their use HUP0400341A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27995601P 2001-03-29 2001-03-29
US10/104,382 US6900214B2 (en) 2001-03-29 2002-03-22 Cyano-substituted dihydropyrimidine compounds and their use to treat diseases
PCT/US2002/009494 WO2002079169A1 (en) 2001-03-29 2002-03-26 Cyano-substituted dihydropyrimidine compounds and their use to treat diseases

Publications (2)

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HUP0400341A2 true HUP0400341A2 (hu) 2004-10-28
HUP0400341A3 HUP0400341A3 (en) 2004-11-29

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US (1) US6900214B2 (hu)
EP (1) EP1373223A4 (hu)
JP (1) JP2004529139A (hu)
KR (1) KR20030086328A (hu)
CN (1) CN1500082A (hu)
AR (1) AR035805A1 (hu)
BG (1) BG108195A (hu)
BR (1) BR0208353A (hu)
CA (1) CA2442484A1 (hu)
CZ (1) CZ20032643A3 (hu)
EE (1) EE200300473A (hu)
HR (1) HRP20030874A2 (hu)
HU (1) HUP0400341A3 (hu)
IL (1) IL157442A0 (hu)
IS (1) IS6966A (hu)
MX (1) MXPA03008635A (hu)
NO (1) NO20034301L (hu)
NZ (1) NZ527617A (hu)
PE (1) PE20020997A1 (hu)
PL (1) PL364005A1 (hu)
RU (1) RU2003131975A (hu)
SK (1) SK11072003A3 (hu)
WO (1) WO2002079169A1 (hu)
YU (1) YU75603A (hu)

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FR2883284A1 (fr) * 2005-03-15 2006-09-22 Commissariat Energie Atomique Nouveaux derives dihydropyrimidines et leur utilisation comme agents anti-cancereux
TW200714593A (en) * 2005-03-22 2007-04-16 Kyowa Hakko Kogyo Kk Agent for treatment of solid tumor
TW200720265A (en) * 2005-03-22 2007-06-01 Kyowa Hakko Kogyo Kk Agent for treatment of hematopoietic tumor
WO2006137490A1 (ja) * 2005-06-24 2006-12-28 Kyowa Hakko Kogyo Co., Ltd. 再狭窄治療剤
DE102006002065B4 (de) * 2006-01-16 2007-11-29 Infineon Technologies Austria Ag Kompensationsbauelement mit reduziertem und einstellbarem Einschaltwiderstand
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EP1373223A1 (en) 2004-01-02
HRP20030874A2 (en) 2004-04-30
US20020143026A1 (en) 2002-10-03
JP2004529139A (ja) 2004-09-24
NO20034301D0 (no) 2003-09-26
AR035805A1 (es) 2004-07-14
BR0208353A (pt) 2004-03-23
PE20020997A1 (es) 2002-11-08
YU75603A (sh) 2006-05-25
HUP0400341A3 (en) 2004-11-29
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