HUP0302720A2 - Pirazolo[4,3d]pirimidin-származékok alkalmazása gyógyszerkészítmények előállítására - Google Patents

Pirazolo[4,3d]pirimidin-származékok alkalmazása gyógyszerkészítmények előállítására

Info

Publication number
HUP0302720A2
HUP0302720A2 HU0302720A HUP0302720A HUP0302720A2 HU P0302720 A2 HUP0302720 A2 HU P0302720A2 HU 0302720 A HU0302720 A HU 0302720A HU P0302720 A HUP0302720 A HU P0302720A HU P0302720 A2 HUP0302720 A2 HU P0302720A2
Authority
HU
Hungary
Prior art keywords
group
groups
carbon atoms
atom
hydrogen atom
Prior art date
Application number
HU0302720A
Other languages
English (en)
Inventor
Hans-Michael Eggenweiler
Volker Eiermann
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of HUP0302720A2 publication Critical patent/HUP0302720A2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány (I) általános képletű vegyületek, ahol R1 és R2 jelentéseegymástól függetlenül hidrogénatom, A, OH, OA csoport vagyhalogénatom, vagy R1 és R2 együtt 3-5 szénatomos alkilén-, -O-CH2-CH2-, -CH2-O-CH2-, -O-CH2-O- vagy -O-CH2-CH2-O- csoportot alkot, R3 ésR4 jelentése egymástól függetlenül hidrogénatom vagy A csoport, Xjelentése R5, R6 vagy R7 csoport, amelyek valamennyien R8-calszubsztituálva vannak, R5 jelentése egyenes vagy elágazó láncú 1-10szénatomos alkiléncsoport, amelyben egy vagy két CH2 csoport -CH=CH-csoporttal, oxigén-, kénatommal vagy SO csoporttal helyettesítvelehet, R6 jelentése 5-12 szénatomos cikloalkil- vagy cikloalkil-alkilén-csoport, R7 jelentése fenil- vagy fenilmetil-csoport, R8jelentése COOH, COOA, CONH2, CONHA, CON(A)2 vagy CN csoport, Ajelentése 1-6 szénatomos alkilcsoport, Hal jelentése fluor-, klór-,bróm- vagy jódatom, és fiziológiailag alkalmazható sóik és szolvátjaikalkalmazására vonatkozik angina, magas vérnyomás, pulmonálishipertenzió, szívszélhűdés, ateroszklerózis, a szív ereinekcsökkentett nyitottságával kapcsolatos állapotok, perifériásérmegbetegedések, gutaütés, bronchitis, allergiás asztma, krónikusasztma, allergiás nátha, glaukóma, irritálható bélszindróma, tumorok,veseelégtelenség, májcirrózis és női szexuális rendellenességekkezelésére alkalmas gyógyszer előállítására. Ó
HU0302720A 2000-11-25 2001-10-29 Pirazolo[4,3d]pirimidin-származékok alkalmazása gyógyszerkészítmények előállítására HUP0302720A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10058662A DE10058662A1 (de) 2000-11-25 2000-11-25 Verwendung von Pyrazolo[4,3-d]pyrimidinen
PCT/EP2001/012493 WO2002041880A2 (de) 2000-11-25 2001-10-29 Verwendung von pyrazolo[4,3-d]pyrimidinen

Publications (1)

Publication Number Publication Date
HUP0302720A2 true HUP0302720A2 (hu) 2003-11-28

Family

ID=7664710

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0302720A HUP0302720A2 (hu) 2000-11-25 2001-10-29 Pirazolo[4,3d]pirimidin-származékok alkalmazása gyógyszerkészítmények előállítására

Country Status (18)

Country Link
US (1) US20040023990A1 (hu)
EP (1) EP1357904A2 (hu)
JP (1) JP2004513963A (hu)
KR (1) KR20030051870A (hu)
CN (1) CN1665508A (hu)
AR (1) AR035373A1 (hu)
AU (1) AU2002215979A1 (hu)
BR (1) BR0115187A (hu)
CA (1) CA2429645A1 (hu)
CZ (1) CZ20031668A3 (hu)
DE (1) DE10058662A1 (hu)
HU (1) HUP0302720A2 (hu)
MX (1) MXPA03004498A (hu)
PL (1) PL363077A1 (hu)
RU (1) RU2003117477A (hu)
SK (1) SK7592003A3 (hu)
WO (1) WO2002041880A2 (hu)
ZA (1) ZA200304908B (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19942474A1 (de) * 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo[4,3-d]pyrimidine
SK8192003A3 (en) * 2000-12-19 2003-10-07 Merck Patent Gmbh Pharmaceutical formulation containing pyrazolo[4,3-d]pyrimidines and antithrombotic agents, calcium-antagonists, prostaglandins or prostaglandin derivatives
JP4015176B2 (ja) 2003-04-29 2007-11-28 ファイザー・インク 高血圧症の治療に有用な5,7−ジアミノピラゾロ4,3−ジピリミジン類
US7572799B2 (en) * 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
DK1742950T3 (da) * 2004-04-07 2009-03-16 Pfizer Ltd Pyrazolo-[4,3-D]-pyrimidiner
US11725395B2 (en) 2009-09-04 2023-08-15 Välinge Innovation AB Resilient floor
US8365499B2 (en) 2009-09-04 2013-02-05 Valinge Innovation Ab Resilient floor
RU2019112740A (ru) 2016-09-30 2020-11-02 АСАНА БАЙОСАЙЕНСИЗ, ЭлЭлСи P2x3 и/или p2x2/3 соединения и способы

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2657760B2 (ja) * 1992-07-15 1997-09-24 小野薬品工業株式会社 4−アミノキナゾリン誘導体およびそれを含有する医薬品
GB9423911D0 (en) * 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
US5869486A (en) * 1995-02-24 1999-02-09 Ono Pharmaceutical Co., Ltd. Fused pyrimidines and pyriazines as pharmaceutical compounds
DE19942474A1 (de) * 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo[4,3-d]pyrimidine
DE10031584A1 (de) * 2000-06-29 2002-01-10 Merck Patent Gmbh 5-Aminoalkyl-pyrazolo[4,3-d]pyrimidine

Also Published As

Publication number Publication date
SK7592003A3 (en) 2003-11-04
AR035373A1 (es) 2004-05-12
MXPA03004498A (es) 2003-09-05
WO2002041880A3 (de) 2003-08-28
US20040023990A1 (en) 2004-02-05
CZ20031668A3 (cs) 2003-10-15
WO2002041880A2 (de) 2002-05-30
DE10058662A1 (de) 2002-05-29
BR0115187A (pt) 2004-01-20
PL363077A1 (en) 2004-11-15
CN1665508A (zh) 2005-09-07
CA2429645A1 (en) 2002-05-30
AU2002215979A1 (en) 2002-06-03
KR20030051870A (ko) 2003-06-25
EP1357904A2 (de) 2003-11-05
RU2003117477A (ru) 2004-11-27
JP2004513963A (ja) 2004-05-13
ZA200304908B (en) 2004-07-28

Similar Documents

Publication Publication Date Title
HUP0303315A2 (hu) Pirazolo [4,3-d] pirimidineket és trombózisellenes szereket, kalcium antagonistákat, prosztaglandinokat vagy prosztaglandinszármazékokat tartalmazó gyógyszerkészítmények
HUP0400818A2 (hu) Tieno[2,3-d]pirimidinek alkalmazása és az ezeket tartalmazó gyógyszerkészítmények
HUP0302720A2 (hu) Pirazolo[4,3d]pirimidin-származékok alkalmazása gyógyszerkészítmények előállítására
ATE178044T1 (de) Inhibitoren des arginin-ketoamid-enzyms
HRP20050663A2 (en) Malonamide derivatives as gamma-secretase inhibitors
HUP0303538A2 (hu) Tirozin kinázok Tec családjának tiazolil-vegyület inhibitorai és ezeket tartalmazó gyógyszerkészítmények
DE60315674D1 (de) Neue imidazopyridine und ihre verwendung
CY1110969T1 (el) 5-υποκατεστημενα-2-φαινυλαμινο-βενζαμιδια ως αναστολεiς μεκ
TNSN07050A1 (fr) Derives de triazolopyridinylsulfanyle servant d'inhibiteurs de kinase map p38
BR0314392A (pt) Composto ou um sal do mesmo, composição farmacêutica, uso de um composto, método de tratamento e/ou profilaxia de uma doença inflamatória e/ou alérgica ou deficiência cognitiva em um mamìfero, e, combinação
NO20050851L (no) Kaspase-inhibitorer og anvendelser derav
RU2011124150A (ru) Нафтилуксусные кислоты
EA200802173A1 (ru) Производные терфенила для лечения болезни альцгеймера
BR0011097A (pt) Derivados de 5-fenil-piridina
HUP0301272A2 (hu) 4-Fenil-piridin-származékok, mint neurokinin-1-receptor antagonisták, eljárás az előállításukra és alkalmazásuk gyógyszerkészítmények előállítására
PE20070120A1 (es) Derivados de prostaglandina
RU2006126718A (ru) Миметики гликозаминогликанов (gag)
HUP0303005A2 (hu) Pirazolo[4,3-d]pirimidineket vagy tienopirimidineket és endotelin receptor antagonistákat tartalmazó gyógyszerkészítmények
HUP0303289A2 (hu) Tienopirimidineket és trombózisellenes szereket, kalcium antagonistákat, prosztaglandinokat vagy prosztaglandinszármazékokat tartalmazó gyógyszerkészítmények
MXPA05009788A (es) Derivados del acido 3-(1-[3- (1, 3-benzotiazol -6-il)propilcarbomil] cicloalquil) propanoico como inhibidores de endopeptidasa neutra.
DK1557414T3 (da) IsoquinoIin-forbindelser og medicinsk anvendelse deraf
HUP0401368A2 (hu) Tienopirimidineket és trombózisellenes szereket, kalcium antagonistákat, prosztaglandinokat vagy prosztaglandin származékokat tartalmazó gyógyszerkészítmények
BR0214488A (pt) Derivados de benzotiazol
HUP0302645A2 (hu) Pirazolo[4,3-d]pirimidin-származékok alkalmazása gyógyszerkészítmények előállítására
HUP0202614A2 (hu) Tienopirimidin-vegyületek alkalmazása