HUP0202534A3 - Fused pyrrolecarboxamides: gaba brain receptor ligands and pharmaceutical compositions containing them - Google Patents

Fused pyrrolecarboxamides: gaba brain receptor ligands and pharmaceutical compositions containing them

Info

Publication number
HUP0202534A3
HUP0202534A3 HU0202534A HUP0202534A HUP0202534A3 HU P0202534 A3 HUP0202534 A3 HU P0202534A3 HU 0202534 A HU0202534 A HU 0202534A HU P0202534 A HUP0202534 A HU P0202534A HU P0202534 A3 HUP0202534 A3 HU P0202534A3
Authority
HU
Hungary
Prior art keywords
pharmaceutical compositions
compositions containing
receptor ligands
brain receptor
gaba brain
Prior art date
Application number
HU0202534A
Other languages
English (en)
Original Assignee
Neurogen Corp Branford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp Branford filed Critical Neurogen Corp Branford
Publication of HUP0202534A2 publication Critical patent/HUP0202534A2/hu
Publication of HUP0202534A3 publication Critical patent/HUP0202534A3/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0468Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K51/047Benzodiazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
HU0202534A 1999-08-31 2000-08-30 Fused pyrrolecarboxamides: gaba brain receptor ligands and pharmaceutical compositions containing them HUP0202534A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15178999P 1999-08-31 1999-08-31
US38731199A 1999-08-31 1999-08-31

Publications (2)

Publication Number Publication Date
HUP0202534A2 HUP0202534A2 (hu) 2002-11-28
HUP0202534A3 true HUP0202534A3 (en) 2002-12-28

Family

ID=26848974

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0202534A HUP0202534A3 (en) 1999-08-31 2000-08-30 Fused pyrrolecarboxamides: gaba brain receptor ligands and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US7109351B1 (hu)
EP (1) EP1210328A1 (hu)
JP (1) JP2003508385A (hu)
KR (1) KR20020027613A (hu)
CN (1) CN1372546A (hu)
AP (1) AP2002002420A0 (hu)
AU (1) AU7092800A (hu)
BG (1) BG106459A (hu)
BR (1) BR0013664A (hu)
CA (1) CA2381553A1 (hu)
CR (1) CR6581A (hu)
CZ (1) CZ2002614A3 (hu)
EA (1) EA200200188A1 (hu)
EE (1) EE200200111A (hu)
HR (1) HRP20020104A2 (hu)
HU (1) HUP0202534A3 (hu)
IL (1) IL147971A0 (hu)
IS (1) IS6290A (hu)
MX (1) MXPA02001709A (hu)
NO (1) NO20020948L (hu)
OA (1) OA12015A (hu)
PL (1) PL354513A1 (hu)
SK (1) SK2582002A3 (hu)
TR (1) TR200200544T2 (hu)
WO (1) WO2001016103A1 (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050014939A1 (en) * 1999-08-31 2005-01-20 Neurogen Corporation Fused pyrrolecarboxamides: GABA brain receptor ligands
AU2001241512A1 (en) * 2000-03-13 2001-09-24 Eli Lilly And Company Sulfonamide derivatives
US6723332B2 (en) 2000-05-26 2004-04-20 Neurogen Corporation Oxomidazopyridine-carboxamides
JP2004508359A (ja) 2000-09-06 2004-03-18 ニューロゲン コーポレイション アリール置換テトラヒドロインダゾール、及び、gaba−a受容体に対するリガンドとしてのそれらの使用
WO2002020480A1 (en) * 2000-09-06 2002-03-14 Neurogen Corporation Substituted fused pyrroleimines and pyrazoleimines
US6861529B2 (en) * 2001-07-06 2005-03-01 Pfizer Inc Cycloalkypyrrole-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives
US6852730B2 (en) 2002-02-07 2005-02-08 Neurogen Corporation Substituted fused pyrazolecarboxylic acid arylamides and related compounds
AU2004265189B2 (en) * 2003-08-15 2010-03-04 Banyu Pharmaceutical Co., Ltd. Imidazopyridine derivatives
US7795266B2 (en) 2003-09-25 2010-09-14 Helton David R Tetrahydroindolone derivatives for treament of neurological conditions
US7566781B2 (en) * 2004-05-10 2009-07-28 Banyu Pharmaceutical Co., Ltd. Imidazopyridine compound
US20080275112A1 (en) * 2004-07-23 2008-11-06 Schreiner Peter R Invention Concerning Aminoadamantane Compounds
EA018036B1 (ru) * 2006-11-27 2013-05-30 Х. Лундбекк А/С Гетероариламидные производные
JP2011506445A (ja) * 2007-12-13 2011-03-03 アムジエン・インコーポレーテツド γ−セクレターゼ調節剤
AU2009279936A1 (en) * 2008-08-05 2010-02-11 Banyu Pharmaceutical Co., Ltd. Therapeutic compounds
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455943A (en) 1966-10-21 1969-07-15 American Cyanamid Co Certain 5,8-dihydro-beta-carbolines
US4075343A (en) 1976-09-13 1978-02-21 Pfizer Inc. Anti-allergenic 5-alkoxyimidazo[1,2-A]quinoline-2-carboxylic acids and derivatives thereof
DE3029980A1 (de) 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indolderivate und verfahren zu ihrer herstellung
JPS57123180A (en) 1980-12-17 1982-07-31 Schering Ag 3-substituted beta-carboline, manufacture and psychotropic drug containing same
DE3147276A1 (de) 1981-11-28 1983-06-09 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von indolderivaten, deren verwendung als wertvolle zwischenprodukte und neue 4-hydroxyindole
DE3246932A1 (de) 1982-12-16 1984-06-20 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte 5h-pyrimido(5,4-b)indole
DE3335323A1 (de) 1983-09-27 1985-04-04 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte ss-carboline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB8429739D0 (en) 1984-11-24 1985-01-03 Fbc Ltd Fungicides
DE3535927A1 (de) 1985-10-04 1987-04-09 Schering Ag 3-vinyl- und 3-ethinyl-ss-carbolinderivate, ihre herstellung und ihre verwendung als arzneimittel
AU652968B2 (en) 1990-10-09 1994-09-15 Neurogen Corporation Certain cycloalkyl and azacycloalkyl pyrrolopyrimidines; a new class of gaba brain receptor ligands
US5243049A (en) 1992-01-22 1993-09-07 Neurogen Corporation Certain pyrroloquinolinones: a new class of GABA brain receptor ligands
JPH07503970A (ja) 1992-02-19 1995-04-27 ジ・アップジョン・カンパニー CNS活性を有する3−置換イミダゾ(1,5−a)−キノキサリン類およびキナゾリン類
US5266698A (en) 1992-04-30 1993-11-30 Neurogen Corporation Certain aryl and cycloalkyl fused imidazopyrazinediones; a new class of GABA brain receptor ligands
WO1994017095A1 (en) 1993-01-29 1994-08-04 Ariad Pharmaceuticals, Inc. Analogs of receptor tyrosine activation motifs and therapeutic uses thereof
US5750702A (en) 1993-10-27 1998-05-12 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of GABA brain receptor ligands
US5484944A (en) * 1993-10-27 1996-01-16 Neurogen Corporation Certain fused pyrrolecarboxanilides and their use as GABA brain receptor ligands
US6211365B1 (en) * 1996-01-19 2001-04-03 Neurogen Corporation Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
US5804686A (en) 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
IT1287264B1 (it) * 1996-03-21 1998-08-04 Lino Crespan Freno perfezionato per pattini con ruote in linea
US5955465A (en) 1996-03-22 1999-09-21 Neurogen Corporation 1,2,4-triazolo 4,3-c!quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones
US5677309A (en) 1996-03-22 1997-10-14 Neurogen Corporation 1,2,4-triazolo 4,3-c! quinazolin-3-ones and 1,2,4-triazolo 4,3-c!quinazolin-3-thiones; a new class of GABA brain receptor ligands
AU2218997A (en) 1996-03-22 1997-10-10 Neurogen Corporation Certain fused pyrrolecarboxamides as gaba brain receptor ligands
US5723462A (en) 1996-04-26 1998-03-03 Neurogen Corporation Certain fused pyrrolecarboxamides a new class of GABA brain receptor ligands
SK6872000A3 (en) * 1997-11-13 2002-02-05 Pfizer Prod Inc Method of synthesis of pyrrole amides

Also Published As

Publication number Publication date
AU7092800A (en) 2001-03-26
JP2003508385A (ja) 2003-03-04
WO2001016103A1 (en) 2001-03-08
PL354513A1 (en) 2004-01-26
CA2381553A1 (en) 2001-03-08
IL147971A0 (en) 2002-09-12
NO20020948L (no) 2002-02-28
BR0013664A (pt) 2002-05-14
EP1210328A1 (en) 2002-06-05
TR200200544T2 (tr) 2002-06-21
EE200200111A (et) 2003-06-16
MXPA02001709A (es) 2002-10-23
CZ2002614A3 (cs) 2002-08-14
AP2002002420A0 (en) 2002-03-31
KR20020027613A (ko) 2002-04-13
CR6581A (es) 2004-03-31
BG106459A (bg) 2002-12-29
IS6290A (is) 2002-02-27
US7109351B1 (en) 2006-09-19
CN1372546A (zh) 2002-10-02
SK2582002A3 (en) 2003-02-04
NO20020948D0 (no) 2002-02-27
HRP20020104A2 (en) 2004-02-29
OA12015A (en) 2006-04-19
EA200200188A1 (ru) 2002-08-29
HUP0202534A2 (hu) 2002-11-28

Similar Documents

Publication Publication Date Title
HU9800985D0 (en) Retarde polymere compositions for pharmaceutical compositions
HUP0201376A2 (en) Thiazoloderivatives and pharmaceutical compositions containing them and process for preparation the compounds
CZ20011518A3 (cs) Farmaceutický prostředek
PL348112A1 (en) Pharmaceutical moxifloxacin preparation
HUP0203514A3 (en) Quinuclidine compounds and drugs containing them and process for preparation the same
HUP0100731A3 (en) New oxazolidine-, thiazolidine-, pyrrolidine-and piperidin derivatives process for their preparation and pharmaceutical compositions containing them
HUP0105108A3 (en) Amide compounds, process for their preparation and pharmaceutical compositions containing them
GB9706089D0 (en) Pharmaceutical composition
IL183972A0 (en) Pharmaceutical composition for modified release insulin sensitiser
HUP0202534A3 (en) Fused pyrrolecarboxamides: gaba brain receptor ligands and pharmaceutical compositions containing them
HUP0201402A3 (en) Bis-sulfonamides, process for their preparation and pharmaceutical compositions containing them
HUP0000137A3 (en) Controller-release pharmaceutical composition containing anangetics
HUP0103340A2 (hu) Kondenzált arilgyűrűt tarrtalmazó azapoliciklusos vegyületek és ezeket tartalmazó gyógyszerkészítmények
IL133928A0 (en) Pharmaceutical composition containing peptichemio
GB9717444D0 (en) Pharmaceutical composition
ZA982073B (en) Pharmaceutical preparation
HUP0002455A3 (en) Gastric-retained pharmaceutical composition
GB9717428D0 (en) Pharmaceutical composition
IL122920A (en) Castrointestinal drug composition
HUP0002777A3 (en) Fused thiazolobenzoheterocyclic derivatives, process for their preparation and pharmaceutical compositions containing same
GB9717770D0 (en) Pharmaceutical composition
GB2321190B (en) Pharmaceutical composition
GB9726781D0 (en) Pharmaceutical composition
HUP0101012A3 (en) Pharmaceutical composition for oral administration
IL120319A0 (en) Pharmaceutical preparation