HUP0105235A3 - Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors, pharmaceutical compositions comprising thereof and their use - Google Patents
Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors, pharmaceutical compositions comprising thereof and their useInfo
- Publication number
- HUP0105235A3 HUP0105235A3 HU0105235A HUP0105235A HUP0105235A3 HU P0105235 A3 HUP0105235 A3 HU P0105235A3 HU 0105235 A HU0105235 A HU 0105235A HU P0105235 A HUP0105235 A HU P0105235A HU P0105235 A3 HUP0105235 A3 HU P0105235A3
- Authority
- HU
- Hungary
- Prior art keywords
- terminally
- bis
- amino acid
- pharmaceutical compositions
- benzyl group
- Prior art date
Links
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 title 1
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11574699P | 1999-01-13 | 1999-01-13 | |
| PCT/US2000/000820 WO2000042060A1 (en) | 1999-01-13 | 2000-01-13 | Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0105235A2 HUP0105235A2 (hu) | 2002-04-29 |
| HUP0105235A3 true HUP0105235A3 (en) | 2002-08-28 |
Family
ID=22363180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0105235A HUP0105235A3 (en) | 1999-01-13 | 2000-01-13 | Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors, pharmaceutical compositions comprising thereof and their use |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1140983A1 (sk) |
| JP (1) | JP2002536298A (sk) |
| KR (1) | KR20010101478A (sk) |
| CN (1) | CN1336934A (sk) |
| AU (1) | AU2725700A (sk) |
| BR (1) | BR0007854A (sk) |
| CA (1) | CA2353088A1 (sk) |
| CZ (1) | CZ20012435A3 (sk) |
| HU (1) | HUP0105235A3 (sk) |
| IL (1) | IL143763A0 (sk) |
| NO (1) | NO20013338L (sk) |
| PL (1) | PL349774A1 (sk) |
| SK (1) | SK9522001A3 (sk) |
| TR (1) | TR200102033T2 (sk) |
| WO (1) | WO2000042060A1 (sk) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7339078B2 (en) | 1995-03-10 | 2008-03-04 | G.D. Searle Llc | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US6861539B1 (en) | 1995-03-10 | 2005-03-01 | G. D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| EP1188766A1 (en) | 1995-03-10 | 2002-03-20 | G.D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US6617310B2 (en) | 2000-07-19 | 2003-09-09 | Bristol-Myers Squibb Pharma Company | Phosphate esters of bis-amino acid sulfonamides containing substituted benzyl amines |
| US20020022742A1 (en) * | 2000-07-19 | 2002-02-21 | Harris Gregory D. | Salt forms of an HIV protease inhibitor |
| US20020022659A1 (en) * | 2000-07-19 | 2002-02-21 | Harris Gregory D. | Crystalline and salt forms of an HIV protease inhibitor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100336699B1 (ko) * | 1992-08-25 | 2002-05-13 | 윌리암스 로저 에이 | 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드 |
| ES2127938T3 (es) * | 1993-08-24 | 1999-05-01 | Searle & Co | Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas. |
| US6150556A (en) * | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
-
2000
- 2000-01-13 EP EP00905604A patent/EP1140983A1/en not_active Withdrawn
- 2000-01-13 HU HU0105235A patent/HUP0105235A3/hu unknown
- 2000-01-13 BR BR0007854-9A patent/BR0007854A/pt not_active IP Right Cessation
- 2000-01-13 WO PCT/US2000/000820 patent/WO2000042060A1/en not_active Application Discontinuation
- 2000-01-13 KR KR1020017008803A patent/KR20010101478A/ko not_active Application Discontinuation
- 2000-01-13 IL IL14376300A patent/IL143763A0/xx unknown
- 2000-01-13 SK SK952-2001A patent/SK9522001A3/sk unknown
- 2000-01-13 JP JP2000593627A patent/JP2002536298A/ja active Pending
- 2000-01-13 CA CA002353088A patent/CA2353088A1/en not_active Abandoned
- 2000-01-13 PL PL00349774A patent/PL349774A1/xx not_active Application Discontinuation
- 2000-01-13 CZ CZ20012435A patent/CZ20012435A3/cs unknown
- 2000-01-13 CN CN00802755A patent/CN1336934A/zh active Pending
- 2000-01-13 TR TR2001/02033T patent/TR200102033T2/xx unknown
- 2000-01-13 AU AU27257/00A patent/AU2725700A/en not_active Abandoned
-
2001
- 2001-07-05 NO NO20013338A patent/NO20013338L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL349774A1 (en) | 2002-09-09 |
| EP1140983A1 (en) | 2001-10-10 |
| KR20010101478A (ko) | 2001-11-14 |
| NO20013338L (no) | 2001-09-13 |
| BR0007854A (pt) | 2002-01-15 |
| SK9522001A3 (en) | 2002-03-05 |
| CZ20012435A3 (cs) | 2002-02-13 |
| AU2725700A (en) | 2000-08-01 |
| IL143763A0 (en) | 2002-04-21 |
| JP2002536298A (ja) | 2002-10-29 |
| NO20013338D0 (no) | 2001-07-05 |
| CA2353088A1 (en) | 2000-07-20 |
| TR200102033T2 (tr) | 2001-12-21 |
| WO2000042060A1 (en) | 2000-07-20 |
| HUP0105235A2 (hu) | 2002-04-29 |
| CN1336934A (zh) | 2002-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0200347A3 (en) | N-cyanomethylamides as protease inhibitors, pharmaceutical compositions containing them and their use | |
| HUP0300855A3 (en) | Peptidmomimetic protease inhibitors, pharmaceutical compositions and their use | |
| HUP0300720A3 (en) | Serine protease inhibitors, pharmaceutical compositions containing them and their use | |
| HUP0204514A3 (en) | Pyridinylimidazoles, pharmaceutical compositions containing them and their use | |
| HUP0401567A3 (en) | Novel 4,5-dyhydro-1h-pyrazole derivatives having cb1-antagonistic activity, their use and pharmaceutical compositions containing them | |
| HUP0302969A3 (en) | Npyy5 antagonists, pharmaceutical compositions containing them and their use | |
| HUP0301573A3 (en) | Substituted arylpyrazines, pharmaceutical compositions containing them and their use | |
| PL343466A1 (en) | Substituted benzamides, their production and their use as cysteine protease inhibitors | |
| IL159076A0 (en) | Hiv protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis | |
| IL149138A0 (en) | Pharmaceutical compositions containing metformin | |
| MXPA03000771A (es) | Nuevas composiciones farmaceuticas. | |
| HUP0301577A3 (en) | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors, pharmaceutical compositions containing them and their use | |
| AU3960400A (en) | Use of metformin in the preparation of pharmaceutical compositions capable of inhibiting the enzyme dipeptidyl peptidase iv | |
| HUP0203325A3 (en) | Bicyclic amino acids, pharmaceutical compositions containing them and their use | |
| HUP0300909A3 (en) | 2-guanidino-4-arylchinazolines as nhe-3 inhibitors, pharmaceutical compositions containing them and their use | |
| HUP0303149A3 (en) | Aminopyridinyl-, aminoguanidinyl- and alkoxyguanidinyl- substituted phenyl acetamides as protease inhibitors, their use and pharmaceutical compositions containing them | |
| HUP0102255A3 (en) | Vla-4 inhibitor omepupa-v, pharmaceutical compositions comprising thereof and their use | |
| HUP0203194A3 (en) | Phenylpiperazines, pharmaceutical compositions containing them and their use | |
| HUP0400967A3 (en) | Substituted 2-anilino-benzimidazoles, their use and pharmaceutical compositions containing them | |
| HUP0201591A2 (en) | Pharmaceutical formulations comprising an hiv protease inhibitor | |
| HUP0201910A3 (en) | Novel aminobenzophenones, pharmaceutical compositions containing them and their use | |
| HUP0200121A3 (en) | Calcilytic compounds, pharmaceutical compositions containing them and their use | |
| HUP0105235A3 (en) | Bis-amino acid sulfonamides containing n-terminally a substituted benzyl group as hiv protease inhibitors, pharmaceutical compositions comprising thereof and their use | |
| HK1047100A1 (en) | New metalloprotease inhibitors, a process for their preparation and pharmaceutical compositions containing them. | |
| HUP0200242A3 (en) | Pyrazole-3-on-derivatives as factor xa inhibitors, pharmaceutical compositions containing them, their preparation and their use |