HUP0104623A2 - Ciklosporin oldat, azt tartalmazó gyógyszerkészítmény és alkalmazása - Google Patents
Ciklosporin oldat, azt tartalmazó gyógyszerkészítmény és alkalmazásaInfo
- Publication number
- HUP0104623A2 HUP0104623A2 HU0104623A HUP0104623A HUP0104623A2 HU P0104623 A2 HUP0104623 A2 HU P0104623A2 HU 0104623 A HU0104623 A HU 0104623A HU P0104623 A HUP0104623 A HU P0104623A HU P0104623 A2 HUP0104623 A2 HU P0104623A2
- Authority
- HU
- Hungary
- Prior art keywords
- ciclosporin
- water
- preparation
- solution
- active substance
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 6
- 108010036949 Cyclosporine Proteins 0.000 title abstract 5
- 229960001265 ciclosporin Drugs 0.000 title abstract 5
- 229930182912 cyclosporin Natural products 0.000 title abstract 3
- 229930105110 Cyclosporin A Natural products 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 2
- 239000002736 nonionic surfactant Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 abstract 1
- 235000004866 D-panthenol Nutrition 0.000 abstract 1
- 239000011703 D-panthenol Substances 0.000 abstract 1
- 239000003945 anionic surfactant Substances 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 229960003949 dexpanthenol Drugs 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008183 oral pharmaceutical preparation Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Abstract
A tal lm ny egy ciklosporin oldatra vonatkozik, amelyet kiz rólagvízzel elegyíthető segédanyagokkal, amilyen a dexpantenol, egy anionostenzid és egy nemionos tenzid vagy nemionos tenzidek keveréke,llítanak elő. A hatóanyag ilyen k"rülmények k"z"tt vízben stabilkolloid oldatokat képez és ezek vízzel tetszés szerint hígíthatókanélkül, hogy a ciklosporin kicsapódna. A biológiai tolerancia vizsglatok arra mutattak, hogy a hatóanyag or lis bevitel ut n jól abszorbelódik. Az előnyben részesített ciklosporin a ciklosporin A. A tal lmny t rgy t képezi a ciklosporint tartalmazó gyógyszerkészítmény is,amelynek alakja előny"sen iható oldat vagy ezt tartalmazó kapszula. Atal lm ny szerinti készítmény alkalmazható az immunrendszert blokkolóor lis gyógyszerkészítmény elő llít s ra. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19859910A DE19859910C2 (de) | 1998-12-23 | 1998-12-23 | Orales Arzneimittel |
| PCT/EP1999/010358 WO2000038702A1 (de) | 1998-12-23 | 1999-12-23 | Cyclosporin-lösung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0104623A2 true HUP0104623A2 (hu) | 2002-04-29 |
| HUP0104623A3 HUP0104623A3 (en) | 2002-08-28 |
Family
ID=7892567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104623A HUP0104623A3 (en) | 1998-12-23 | 1999-12-23 | Cyclosporin solution, pharmaceutical composition comprising thereof and its use |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1140135B1 (hu) |
| JP (1) | JP2002533401A (hu) |
| AT (1) | ATE249834T1 (hu) |
| AU (1) | AU762963B2 (hu) |
| CA (1) | CA2355271A1 (hu) |
| CZ (1) | CZ20012143A3 (hu) |
| DE (2) | DE19859910C2 (hu) |
| DK (1) | DK1140135T3 (hu) |
| ES (1) | ES2203235T3 (hu) |
| HK (1) | HK1037140A1 (hu) |
| HU (1) | HUP0104623A3 (hu) |
| NO (1) | NO20012932D0 (hu) |
| PL (1) | PL348180A1 (hu) |
| PT (1) | PT1140135E (hu) |
| RU (1) | RU2216342C2 (hu) |
| SK (1) | SK8702001A3 (hu) |
| WO (1) | WO2000038702A1 (hu) |
| ZA (1) | ZA200104828B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| DE102009037551A1 (de) | 2009-08-17 | 2011-02-24 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Cyclosporinderivate |
| DE102011111991A1 (de) | 2011-08-30 | 2013-02-28 | Lead Discovery Center Gmbh | Neue Cyclosporin-Derivate |
| US8957048B2 (en) | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
| US9907826B2 (en) | 2011-12-07 | 2018-03-06 | Allergan, Inc. | Efficient lipid delivery to human tear film using a salt-sensitive emulsion system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8903804D0 (en) * | 1989-02-20 | 1989-04-05 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
| DK0813865T3 (da) * | 1993-04-20 | 2001-11-19 | Hexal Ag | Plaster med virksomt stof |
| US5603951A (en) * | 1994-11-09 | 1997-02-18 | Hanmi Pharm. Ind. Co., Ltd. | Cyclosporin-containing soft capsule compositions |
| US5798333A (en) * | 1996-09-17 | 1998-08-25 | Sherman; Bernard C. | Water-soluble concentrates containing cyclosporins |
| CZ301382B6 (cs) * | 1997-03-12 | 2010-02-10 | Abbott Laboratories Chad377/Ap6D-2 | Hydrofilní binární systémy pro podávání cyklosporinu |
-
1998
- 1998-12-23 DE DE19859910A patent/DE19859910C2/de not_active Expired - Fee Related
-
1999
- 1999-12-23 RU RU2001120359/14A patent/RU2216342C2/ru not_active IP Right Cessation
- 1999-12-23 AT AT99964670T patent/ATE249834T1/de not_active IP Right Cessation
- 1999-12-23 EP EP99964670A patent/EP1140135B1/de not_active Expired - Lifetime
- 1999-12-23 ES ES99964670T patent/ES2203235T3/es not_active Expired - Lifetime
- 1999-12-23 HU HU0104623A patent/HUP0104623A3/hu unknown
- 1999-12-23 JP JP2000590654A patent/JP2002533401A/ja active Pending
- 1999-12-23 DK DK99964670T patent/DK1140135T3/da active
- 1999-12-23 CZ CZ20012143A patent/CZ20012143A3/cs unknown
- 1999-12-23 PT PT99964670T patent/PT1140135E/pt unknown
- 1999-12-23 CA CA002355271A patent/CA2355271A1/en not_active Abandoned
- 1999-12-23 WO PCT/EP1999/010358 patent/WO2000038702A1/de not_active Application Discontinuation
- 1999-12-23 PL PL99348180A patent/PL348180A1/xx unknown
- 1999-12-23 SK SK870-2001A patent/SK8702001A3/sk unknown
- 1999-12-23 AU AU30434/00A patent/AU762963B2/en not_active Ceased
- 1999-12-23 DE DE59907058T patent/DE59907058D1/de not_active Expired - Fee Related
-
2001
- 2001-06-13 NO NO20012932A patent/NO20012932D0/no not_active Application Discontinuation
- 2001-06-13 ZA ZA200104828A patent/ZA200104828B/en unknown
- 2001-11-07 HK HK01107803A patent/HK1037140A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU3043400A (en) | 2000-07-31 |
| WO2000038702A1 (de) | 2000-07-06 |
| DE59907058D1 (en) | 2003-10-23 |
| CZ20012143A3 (cs) | 2002-01-16 |
| DE19859910A1 (de) | 2000-06-29 |
| ATE249834T1 (de) | 2003-10-15 |
| NO20012932L (no) | 2001-06-13 |
| EP1140135B1 (de) | 2003-09-17 |
| NO20012932D0 (no) | 2001-06-13 |
| ZA200104828B (en) | 2002-09-13 |
| HUP0104623A3 (en) | 2002-08-28 |
| EP1140135A1 (de) | 2001-10-10 |
| SK8702001A3 (en) | 2002-01-07 |
| PL348180A1 (en) | 2002-05-06 |
| HK1037140A1 (en) | 2002-02-01 |
| DE19859910C2 (de) | 2001-03-22 |
| ES2203235T3 (es) | 2004-04-01 |
| PT1140135E (pt) | 2003-12-31 |
| RU2216342C2 (ru) | 2003-11-20 |
| DK1140135T3 (da) | 2003-12-08 |
| JP2002533401A (ja) | 2002-10-08 |
| CA2355271A1 (en) | 2000-07-06 |
| AU762963B2 (en) | 2003-07-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |