HUP0104598A1 - Hepatocita-eredetű növekedési faktorból (HGF) és makrofágstimuláló proteinből (MSP) származó rekombináns proteinek - Google Patents

Hepatocita-eredetű növekedési faktorból (HGF) és makrofágstimuláló proteinből (MSP) származó rekombináns proteinek

Info

Publication number
HUP0104598A1
HUP0104598A1 HU0104598A HUP0104598A HUP0104598A1 HU P0104598 A1 HUP0104598 A1 HU P0104598A1 HU 0104598 A HU0104598 A HU 0104598A HU P0104598 A HUP0104598 A HU P0104598A HU P0104598 A1 HUP0104598 A1 HU P0104598A1
Authority
HU
Hungary
Prior art keywords
recombinant proteins
proteins according
subject
msp
hgf
Prior art date
Application number
HU0104598A
Other languages
English (en)
Inventor
Gianfranco Caselli
Chiara Collesi
Paolo Comoglio
Enzo Medico
Paolo Michieli
Original Assignee
Dompe' S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe' S.P.A. filed Critical Dompe' S.P.A.
Publication of HUP0104598A1 publication Critical patent/HUP0104598A1/hu
Publication of HUP0104598A3 publication Critical patent/HUP0104598A3/hu
Publication of HU226717B1 publication Critical patent/HU226717B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A találmány tárgyát a hepatocitaeredetű növekedési faktor (HGF) és amakrofágstimuláló protein (MSP) a-alegységeiből származó strukturálisdomének kombinálásával előállított rekombináns proteinek képezik. Atalálmány tárgyát képezik továbbá a találmány szerinti rekombinánsproteineket kódoló nukleotidszekvenciák, a nukleotidszekvenciákattartalmazó expressziós vektorok és az expressziós vektorokkaltranszformált prokarióta és eukarióta gazdasejtek. Szintén a találmánytárgyát képezik a találmány szerinti rekombináns proteinek előállításieljárásai, a találmány szerinti proteinek alkalmazása kemoterápiáshatóanyagok okozta toxicitás megelőzésére vagy kezelésére alkalmasgyógyszer előállítására, valamint a találmány szerinti proteinekhatásos mennyiségét tartalmazó gyógyászati készítmények. Ó
HU0104598A 1998-01-30 1999-01-27 Recombinant proteins derived from hgf and msp HU226717B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT98MI000179A ITMI980179A1 (it) 1998-01-30 1998-01-30 Proteine ricombinanti derivate da hgf e msp
PCT/EP1999/000478 WO1999038967A2 (en) 1998-01-30 1999-01-27 Recombinant proteins derived from hgf and msp

Publications (3)

Publication Number Publication Date
HUP0104598A1 true HUP0104598A1 (hu) 2002-03-28
HUP0104598A3 HUP0104598A3 (en) 2003-09-29
HU226717B1 HU226717B1 (en) 2009-07-28

Family

ID=11378771

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104598A HU226717B1 (en) 1998-01-30 1999-01-27 Recombinant proteins derived from hgf and msp

Country Status (14)

Country Link
US (1) US6551991B1 (hu)
EP (1) EP1049778B1 (hu)
JP (1) JP4478329B2 (hu)
AT (1) ATE335080T1 (hu)
AU (1) AU740490B2 (hu)
CA (1) CA2319211C (hu)
DE (1) DE69932592T2 (hu)
ES (1) ES2270581T3 (hu)
HU (1) HU226717B1 (hu)
IL (2) IL137564A0 (hu)
IT (1) ITMI980179A1 (hu)
NZ (1) NZ506005A (hu)
WO (1) WO1999038967A2 (hu)
ZA (1) ZA99723B (hu)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040138120A1 (en) * 2002-10-07 2004-07-15 Genentech, Inc. Hepatocyte growth factor variants
EP1642586A4 (en) * 2003-06-06 2009-06-17 Kringle Pharma Inc CELLULAR PREPARATIONS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
DK0642580T3 (da) * 1992-05-18 2002-12-23 Genentech Inc Hepactocytvækstfaktorvarianter
ES2257734T3 (es) 1992-05-18 2006-08-01 Genentech, Inc. Activacion de los receptores de oligomerizacion por medio de los ligandos de receptores fusionados.
WO1994006456A1 (en) * 1992-09-16 1994-03-31 Genentech, Inc. Protection against liver damage by hgf

Also Published As

Publication number Publication date
EP1049778B1 (en) 2006-08-02
DE69932592D1 (de) 2006-09-14
CA2319211C (en) 2010-10-26
WO1999038967A3 (en) 1999-09-16
IL137564A0 (en) 2001-07-24
NZ506005A (en) 2003-06-30
AU740490B2 (en) 2001-11-08
IL137564A (en) 2007-06-17
DE69932592T2 (de) 2007-08-09
US6551991B1 (en) 2003-04-22
HU226717B1 (en) 2009-07-28
CA2319211A1 (en) 1999-08-05
JP2002501745A (ja) 2002-01-22
ZA99723B (en) 1999-07-29
ITMI980179A1 (it) 1999-07-30
HUP0104598A3 (en) 2003-09-29
ATE335080T1 (de) 2006-08-15
WO1999038967A2 (en) 1999-08-05
AU2424599A (en) 1999-08-16
JP4478329B2 (ja) 2010-06-09
ES2270581T3 (es) 2007-04-01
EP1049778A2 (en) 2000-11-08

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Legal Events

Date Code Title Description
GB9A Succession in title

Owner name: DOMPE' PHA.R.MA S.P.A, IT

Free format text: FORMER OWNER(S): DOMPE' S.P.A., IT

MM4A Lapse of definitive patent protection due to non-payment of fees