HUP0102505A2 - Szelektív ösztrogén receptor modulátorokat (SERM) és növekedési hormon kiválasztását fokozó anyagokat (GHS) együtt tartalmazó csontváz-izomzati gyengeség kezelésére szolgáló gyógyszerkombinációk - Google Patents
Szelektív ösztrogén receptor modulátorokat (SERM) és növekedési hormon kiválasztását fokozó anyagokat (GHS) együtt tartalmazó csontváz-izomzati gyengeség kezelésére szolgáló gyógyszerkombinációkInfo
- Publication number
- HUP0102505A2 HUP0102505A2 HU0102505A HUP0102505A HUP0102505A2 HU P0102505 A2 HUP0102505 A2 HU P0102505A2 HU 0102505 A HU0102505 A HU 0102505A HU P0102505 A HUP0102505 A HU P0102505A HU P0102505 A2 HUP0102505 A2 HU P0102505A2
- Authority
- HU
- Hungary
- Prior art keywords
- ghs
- growth hormone
- estrogen receptor
- receptor modulators
- hormone secretagogues
- Prior art date
Links
- 239000003324 growth hormone secretagogue Substances 0.000 title abstract 3
- 208000036119 Frailty Diseases 0.000 title 1
- 206010003549 asthenia Diseases 0.000 title 1
- 239000002834 estrogen receptor modulator Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 abstract 2
- 210000003205 muscle Anatomy 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000333 selective estrogen receptor modulator Substances 0.000 abstract 2
- 229940095743 selective estrogen receptor modulator Drugs 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000010428 Muscle Weakness Diseases 0.000 abstract 1
- 206010028372 Muscular weakness Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000001164 Osteoporotic Fractures Diseases 0.000 abstract 1
- GXESHMAMLJKROZ-IAPPQJPRSA-N lasofoxifene Chemical compound C1([C@@H]2[C@@H](C3=CC=C(C=C3CC2)O)C=2C=CC(OCCN3CCCC3)=CC=2)=CC=CC=C1 GXESHMAMLJKROZ-IAPPQJPRSA-N 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 210000002027 skeletal muscle Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
A találmány szelektív ösztrogén receptor modulátorok (SERM) ésnövekedési hormon kiválasztását fokozó anyagok (GHS) kombinációjáttartalmazó gyógyszerkészítményekre vonatkozik, amelyek stimulálják acsontképződést, növelik a csonttömeget, csökkentik a szérum lipidszinteket, és növelik az izomtömeget. A találmány továbbá az ezeket akombinációkat tartalmazó kitekre valamint e kombinációk csontváz-izomzati gyengeség, azaz oszteoporózis, oszteoporózisos törés,alacsony csonttömeg, gyengeség, alacsony izomtömeg kezelésére valóalkalmazására vonatkozik állatban és emberben egyaránt. A találmányelsősorban a (-)-cisz-6-fenil-5-(4-(2-pirrolidin-1-il-etoxi)- -fenil)-5, 6, 7, 8-tetrahidronaftalin-2-ol vagy gyógyászatilag elfogadhatósójának valamint a 2-amino-N-(2-(3a(R)-benzil-2-metil-3-oxo-2,3,3a,4,6,7-hexahidro- pirazolo-[4,3-c]piridin-5-il)-1(R)-benziloxi-metil-2-oxo-etil)-izobutir- mid vagy gyógyászatilag elfogadhatósójának a kombinációjára, az e kombinációt tartalmazó kitrevonatkozik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8946998P | 1998-06-16 | 1998-06-16 | |
| PCT/IB1999/001117 WO1999065486A1 (en) | 1998-06-16 | 1999-06-16 | Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0102505A2 true HUP0102505A2 (hu) | 2001-11-28 |
| HUP0102505A3 HUP0102505A3 (en) | 2002-12-28 |
Family
ID=22217825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0102505A HUP0102505A3 (en) | 1998-06-16 | 1999-06-16 | Therapeutic combinations of (selective) estrogen receptor modulators (serm) and growth hormone secretagogues (ghs) for treating musculoskeletal frailty |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1087764A1 (hu) |
| JP (1) | JP2002518326A (hu) |
| KR (1) | KR20010052852A (hu) |
| CN (1) | CN1301160A (hu) |
| AP (1) | AP9901582A0 (hu) |
| AR (1) | AR018869A1 (hu) |
| AU (1) | AU4054799A (hu) |
| BG (1) | BG105041A (hu) |
| BR (1) | BR9911324A (hu) |
| CA (1) | CA2335134A1 (hu) |
| CO (1) | CO5070587A1 (hu) |
| EA (1) | EA200001186A1 (hu) |
| GT (1) | GT199900087A (hu) |
| HN (1) | HN1999000097A (hu) |
| HR (1) | HRP20000859A2 (hu) |
| HU (1) | HUP0102505A3 (hu) |
| ID (1) | ID27599A (hu) |
| IL (1) | IL138630A0 (hu) |
| IS (1) | IS5691A (hu) |
| MA (1) | MA26652A1 (hu) |
| NO (1) | NO20006312D0 (hu) |
| OA (1) | OA11505A (hu) |
| PA (1) | PA8475901A1 (hu) |
| PE (1) | PE20000646A1 (hu) |
| PL (1) | PL344981A1 (hu) |
| SK (1) | SK18912000A3 (hu) |
| TN (1) | TNSN99124A1 (hu) |
| TR (1) | TR200003544T2 (hu) |
| WO (1) | WO1999065486A1 (hu) |
| ZA (1) | ZA993975B (hu) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2360103A1 (en) * | 1999-02-08 | 2000-08-17 | Robert Sladek | Non-human transgenic animal whose germ cells and somatic cells contain a knockout mutation in dna encoding orphan nuclear receptor erralpha |
| DE60124616T2 (de) | 2000-05-08 | 2007-09-13 | Pfizer Products Inc., Groton | Enzymatische Spaltung von selektiven Modulatoren des Östrogenrezeptors |
| IL145106A0 (en) * | 2000-08-30 | 2002-06-30 | Pfizer Prod Inc | Intermittent administration of a geowth hormone secretagogue |
| CA2420535A1 (en) * | 2000-08-30 | 2002-03-07 | Mary Tanya Am Ende | Sustained release formulations for growth hormone secretagogues |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| WO2006024931A2 (en) * | 2004-08-31 | 2006-03-09 | Pfizer Products Inc. | Therapeutic combinations comprising a selective estrogen receptor modulator and a selective androgen receptor modulator |
| CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
| EP2118080B1 (en) | 2007-02-09 | 2016-08-31 | Ocera Therapeutics, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA51676C2 (uk) * | 1995-11-02 | 2002-12-16 | Пфайзер Інк. | (-)цис-6(s)-феніл-5(r)[4-(2-піролідин-1-ілетокси)феніл]-5,6,7,8-тетрагідронафталін-2-ол d-тартрат, спосіб його одержання, спосіб лікування захворювань, що піддаються лікуванню агоністами естрогену, та фармацевтична композиція |
| TW432073B (en) * | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
| HN1996000101A (es) * | 1996-02-28 | 1997-06-26 | Inc Pfizer | Terapia combinada para la osteoporosis |
-
1999
- 1999-06-15 ZA ZA9903975A patent/ZA993975B/xx unknown
- 1999-06-15 PE PE1999000528A patent/PE20000646A1/es not_active Application Discontinuation
- 1999-06-15 PA PA19998475901A patent/PA8475901A1/es unknown
- 1999-06-15 AP APAP/P/1999/001582A patent/AP9901582A0/en unknown
- 1999-06-15 AR ARP990102848A patent/AR018869A1/es not_active Application Discontinuation
- 1999-06-15 HN HN1999000097A patent/HN1999000097A/es unknown
- 1999-06-16 PL PL99344981A patent/PL344981A1/xx not_active Application Discontinuation
- 1999-06-16 JP JP2000554366A patent/JP2002518326A/ja active Pending
- 1999-06-16 HU HU0102505A patent/HUP0102505A3/hu unknown
- 1999-06-16 AU AU40547/99A patent/AU4054799A/en not_active Abandoned
- 1999-06-16 ID IDW20002627A patent/ID27599A/id unknown
- 1999-06-16 EA EA200001186A patent/EA200001186A1/ru unknown
- 1999-06-16 SK SK1891-2000A patent/SK18912000A3/sk unknown
- 1999-06-16 MA MA25628A patent/MA26652A1/fr unknown
- 1999-06-16 CO CO99037622A patent/CO5070587A1/es unknown
- 1999-06-16 TR TR2000/03544T patent/TR200003544T2/xx unknown
- 1999-06-16 TN TNTNSN99124A patent/TNSN99124A1/fr unknown
- 1999-06-16 IL IL13863099A patent/IL138630A0/xx unknown
- 1999-06-16 CA CA002335134A patent/CA2335134A1/en not_active Abandoned
- 1999-06-16 CN CN99806237A patent/CN1301160A/zh active Pending
- 1999-06-16 WO PCT/IB1999/001117 patent/WO1999065486A1/en not_active Application Discontinuation
- 1999-06-16 KR KR1020007014186A patent/KR20010052852A/ko not_active Application Discontinuation
- 1999-06-16 GT GT199900087A patent/GT199900087A/es unknown
- 1999-06-16 EP EP99923802A patent/EP1087764A1/en not_active Withdrawn
- 1999-06-16 BR BR9911324-4A patent/BR9911324A/pt not_active Application Discontinuation
-
2000
- 2000-10-20 OA OA1200000290A patent/OA11505A/en unknown
- 2000-10-27 IS IS5691A patent/IS5691A/is unknown
- 2000-12-11 BG BG105041A patent/BG105041A/xx unknown
- 2000-12-12 NO NO20006312A patent/NO20006312D0/no not_active Application Discontinuation
- 2000-12-14 HR HR20000859A patent/HRP20000859A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0102505A3 (en) | 2002-12-28 |
| AR018869A1 (es) | 2001-12-12 |
| PE20000646A1 (es) | 2000-08-05 |
| AP9901582A0 (en) | 1999-06-30 |
| PA8475901A1 (es) | 2000-05-24 |
| ID27599A (id) | 2001-04-12 |
| KR20010052852A (ko) | 2001-06-25 |
| WO1999065486A1 (en) | 1999-12-23 |
| OA11505A (en) | 2004-05-07 |
| BG105041A (en) | 2001-08-31 |
| AU4054799A (en) | 2000-01-05 |
| SK18912000A3 (sk) | 2001-10-08 |
| IS5691A (is) | 2000-10-27 |
| MA26652A1 (fr) | 2004-12-20 |
| IL138630A0 (en) | 2001-10-31 |
| BR9911324A (pt) | 2001-04-03 |
| NO20006312L (no) | 2000-12-12 |
| HN1999000097A (es) | 1999-11-03 |
| PL344981A1 (en) | 2001-11-19 |
| CA2335134A1 (en) | 1999-12-23 |
| NO20006312D0 (no) | 2000-12-12 |
| CN1301160A (zh) | 2001-06-27 |
| EP1087764A1 (en) | 2001-04-04 |
| JP2002518326A (ja) | 2002-06-25 |
| HRP20000859A2 (en) | 2001-04-30 |
| TNSN99124A1 (fr) | 2005-11-10 |
| TR200003544T2 (tr) | 2001-04-20 |
| CO5070587A1 (es) | 2001-08-28 |
| ZA993975B (en) | 2000-12-15 |
| EA200001186A1 (ru) | 2001-06-25 |
| GT199900087A (es) | 2000-12-07 |
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