HUP0003023A2 - (S)-[2-Fenil-2-(metil-amino)-butil]-3,4,5-trimetoxi-benzoát és alkalmazása krónikus fájdalmak kezelésében - Google Patents

(S)-[2-Fenil-2-(metil-amino)-butil]-3,4,5-trimetoxi-benzoát és alkalmazása krónikus fájdalmak kezelésében

Info

Publication number
HUP0003023A2
HUP0003023A2 HU0003023A HUP0003023A HUP0003023A2 HU P0003023 A2 HUP0003023 A2 HU P0003023A2 HU 0003023 A HU0003023 A HU 0003023A HU P0003023 A HUP0003023 A HU P0003023A HU P0003023 A2 HUP0003023 A2 HU P0003023A2
Authority
HU
Hungary
Prior art keywords
trimethoxybenzoate
phenyl
butyl
treatment
chronic pain
Prior art date
Application number
HU0003023A
Other languages
English (en)
Inventor
Svein Gunwald Dahl
Agnes Grouhel
Henry Jacobelli
Francois Joseph Roman
Original Assignee
Parke-Davis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Parke-Davis filed Critical Parke-Davis
Publication of HUP0003023A2 publication Critical patent/HUP0003023A2/hu
Publication of HUP0003023A3 publication Critical patent/HUP0003023A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Atalálmány optikailag tiszta, (I) képletű (S)-[2-fenil-2-(metil-amino)-butil]-3,4,5-trimetoxi-benzoátra, a vegyület gyógyászatilagelfogadható savakkal alkotott addíciós sóira, valamint az előbbiekelőállítási eljárására vonatkozik. Atalálmány kiterjed krónikusfájdalmak kezelésére szolgáló, hatóanyagként (I) képletű vegyületetvagy ennek egy gyógyászatilag elfogadható sóját tartalmazógyógyszerkészítményekre, valamint a vegyületeknek agyógyszerkészítmények előállítására történő felhasználására is. Ó
HU0003023A 1997-06-30 1998-06-23 (s) 2-methylamino-2-phenyl-n-butyl 3,4,5-trimethoxybenzoate, its application to the treatment of chronic pain HUP0003023A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9708323A FR2765218B1 (fr) 1997-06-30 1997-06-30 Le (s) 3,4,5-trimethoxybenzoate de 2-methylamino-2-phenyl-n- butyle, son application au traitement des douleurs chroniques

Publications (2)

Publication Number Publication Date
HUP0003023A2 true HUP0003023A2 (hu) 2001-01-29
HUP0003023A3 HUP0003023A3 (en) 2001-12-28

Family

ID=9508729

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003023A HUP0003023A3 (en) 1997-06-30 1998-06-23 (s) 2-methylamino-2-phenyl-n-butyl 3,4,5-trimethoxybenzoate, its application to the treatment of chronic pain

Country Status (16)

Country Link
EP (1) EP0993436A1 (hu)
JP (1) JP2002508776A (hu)
KR (1) KR20010014294A (hu)
AU (1) AU731887B2 (hu)
BR (1) BR9810387A (hu)
CA (1) CA2285479A1 (hu)
FR (1) FR2765218B1 (hu)
HU (1) HUP0003023A3 (hu)
IL (1) IL133398A0 (hu)
IS (1) IS5324A (hu)
MX (1) MXPA99009120A (hu)
NO (1) NO996496D0 (hu)
NZ (1) NZ500212A (hu)
PL (1) PL337665A1 (hu)
WO (1) WO1999001417A1 (hu)
ZA (1) ZA985668B (hu)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1110549A1 (en) 1999-12-23 2001-06-27 Warner-Lambert Company Use of trimebutine for treating pain
FR2927076B1 (fr) 2008-01-31 2010-03-26 Oroxcell Derives de 2-amino-2-phenyl-alkanol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2948660B1 (fr) 2009-07-30 2011-08-19 Oroxcell Derives de 2-amino-2-phenyl-alkanol, leur preparation et les compositions pharmaceutiques qui les contiennent
CA2866771A1 (en) * 2012-03-12 2013-09-19 Gicare Pharma Inc. Novel sulfonate-based trimebutine salts
RU2752086C1 (ru) * 2020-04-27 2021-07-22 Общество С Ограниченной Ответственностью "Валента-Интеллект" Новое соединение [2-(диметиламино)-2-фенилбутил]-3,4,5-триметоксибензоата 4-метил-2н-хромен-2-он-7-илсульфат и его применение

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1434826A (en) * 1973-11-14 1976-05-05 Gallardo Antonio Sa Esters and carbamates of aminoalkanols

Also Published As

Publication number Publication date
IS5324A (is) 1999-12-28
AU8540598A (en) 1999-01-25
FR2765218A1 (fr) 1998-12-31
WO1999001417A1 (en) 1999-01-14
EP0993436A1 (en) 2000-04-19
BR9810387A (pt) 2000-09-05
JP2002508776A (ja) 2002-03-19
CA2285479A1 (en) 1999-01-14
AU731887B2 (en) 2001-04-05
HUP0003023A3 (en) 2001-12-28
PL337665A1 (en) 2000-08-28
IL133398A0 (en) 2001-04-30
ZA985668B (en) 1999-01-25
NO996496L (no) 1999-12-27
KR20010014294A (ko) 2001-02-26
MXPA99009120A (es) 2005-01-10
NO996496D0 (no) 1999-12-27
NZ500212A (en) 2001-07-27
FR2765218B1 (fr) 1999-08-13

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees