HUP0003023A2 - (S)-[2-Fenil-2-(metil-amino)-butil]-3,4,5-trimetoxi-benzoát és alkalmazása krónikus fájdalmak kezelésében - Google Patents
(S)-[2-Fenil-2-(metil-amino)-butil]-3,4,5-trimetoxi-benzoát és alkalmazása krónikus fájdalmak kezelésébenInfo
- Publication number
- HUP0003023A2 HUP0003023A2 HU0003023A HUP0003023A HUP0003023A2 HU P0003023 A2 HUP0003023 A2 HU P0003023A2 HU 0003023 A HU0003023 A HU 0003023A HU P0003023 A HUP0003023 A HU P0003023A HU P0003023 A2 HUP0003023 A2 HU P0003023A2
- Authority
- HU
- Hungary
- Prior art keywords
- trimethoxybenzoate
- phenyl
- butyl
- treatment
- chronic pain
- Prior art date
Links
- 208000000094 Chronic Pain Diseases 0.000 title abstract 2
- 208000002193 Pain Diseases 0.000 title abstract 2
- ZFPDLGDYDUPYEZ-OAQYLSRUSA-N [(2s)-2-(methylamino)-2-phenylbutyl] 3,4,5-trimethoxybenzoate Chemical compound C([C@@](CC)(NC)C=1C=CC=CC=1)OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 ZFPDLGDYDUPYEZ-OAQYLSRUSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Atalálmány optikailag tiszta, (I) képletű (S)-[2-fenil-2-(metil-amino)-butil]-3,4,5-trimetoxi-benzoátra, a vegyület gyógyászatilagelfogadható savakkal alkotott addíciós sóira, valamint az előbbiekelőállítási eljárására vonatkozik. Atalálmány kiterjed krónikusfájdalmak kezelésére szolgáló, hatóanyagként (I) képletű vegyületetvagy ennek egy gyógyászatilag elfogadható sóját tartalmazógyógyszerkészítményekre, valamint a vegyületeknek agyógyszerkészítmények előállítására történő felhasználására is. Ó
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9708323A FR2765218B1 (fr) | 1997-06-30 | 1997-06-30 | Le (s) 3,4,5-trimethoxybenzoate de 2-methylamino-2-phenyl-n- butyle, son application au traitement des douleurs chroniques |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0003023A2 true HUP0003023A2 (hu) | 2001-01-29 |
HUP0003023A3 HUP0003023A3 (en) | 2001-12-28 |
Family
ID=9508729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0003023A HUP0003023A3 (en) | 1997-06-30 | 1998-06-23 | (s) 2-methylamino-2-phenyl-n-butyl 3,4,5-trimethoxybenzoate, its application to the treatment of chronic pain |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0993436A1 (hu) |
JP (1) | JP2002508776A (hu) |
KR (1) | KR20010014294A (hu) |
AU (1) | AU731887B2 (hu) |
BR (1) | BR9810387A (hu) |
CA (1) | CA2285479A1 (hu) |
FR (1) | FR2765218B1 (hu) |
HU (1) | HUP0003023A3 (hu) |
IL (1) | IL133398A0 (hu) |
IS (1) | IS5324A (hu) |
MX (1) | MXPA99009120A (hu) |
NO (1) | NO996496D0 (hu) |
NZ (1) | NZ500212A (hu) |
PL (1) | PL337665A1 (hu) |
WO (1) | WO1999001417A1 (hu) |
ZA (1) | ZA985668B (hu) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1110549A1 (en) | 1999-12-23 | 2001-06-27 | Warner-Lambert Company | Use of trimebutine for treating pain |
FR2927076B1 (fr) | 2008-01-31 | 2010-03-26 | Oroxcell | Derives de 2-amino-2-phenyl-alkanol, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2948660B1 (fr) | 2009-07-30 | 2011-08-19 | Oroxcell | Derives de 2-amino-2-phenyl-alkanol, leur preparation et les compositions pharmaceutiques qui les contiennent |
WO2013134869A1 (en) * | 2012-03-12 | 2013-09-19 | Gicare Pharma Inc. | Novel sulfonate-based trimebutine salts |
RU2752086C1 (ru) * | 2020-04-27 | 2021-07-22 | Общество С Ограниченной Ответственностью "Валента-Интеллект" | Новое соединение [2-(диметиламино)-2-фенилбутил]-3,4,5-триметоксибензоата 4-метил-2н-хромен-2-он-7-илсульфат и его применение |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1434826A (en) * | 1973-11-14 | 1976-05-05 | Gallardo Antonio Sa | Esters and carbamates of aminoalkanols |
-
1997
- 1997-06-30 FR FR9708323A patent/FR2765218B1/fr not_active Expired - Fee Related
-
1998
- 1998-06-23 IL IL13339898A patent/IL133398A0/xx unknown
- 1998-06-23 NZ NZ500212A patent/NZ500212A/en unknown
- 1998-06-23 EP EP98936382A patent/EP0993436A1/en not_active Withdrawn
- 1998-06-23 PL PL98337665A patent/PL337665A1/xx unknown
- 1998-06-23 CA CA002285479A patent/CA2285479A1/en not_active Abandoned
- 1998-06-23 JP JP50625999A patent/JP2002508776A/ja active Pending
- 1998-06-23 HU HU0003023A patent/HUP0003023A3/hu unknown
- 1998-06-23 KR KR1019997012424A patent/KR20010014294A/ko not_active Application Discontinuation
- 1998-06-23 AU AU85405/98A patent/AU731887B2/en not_active Ceased
- 1998-06-23 MX MXPA99009120A patent/MXPA99009120A/es unknown
- 1998-06-23 BR BR9810387-3A patent/BR9810387A/pt not_active IP Right Cessation
- 1998-06-23 WO PCT/EP1998/003825 patent/WO1999001417A1/en not_active Application Discontinuation
- 1998-06-29 ZA ZA985668A patent/ZA985668B/xx unknown
-
1999
- 1999-12-27 NO NO996496A patent/NO996496D0/no not_active Application Discontinuation
- 1999-12-28 IS IS5324A patent/IS5324A/is unknown
Also Published As
Publication number | Publication date |
---|---|
BR9810387A (pt) | 2000-09-05 |
IS5324A (is) | 1999-12-28 |
ZA985668B (en) | 1999-01-25 |
HUP0003023A3 (en) | 2001-12-28 |
AU8540598A (en) | 1999-01-25 |
NO996496L (no) | 1999-12-27 |
IL133398A0 (en) | 2001-04-30 |
WO1999001417A1 (en) | 1999-01-14 |
MXPA99009120A (es) | 2005-01-10 |
FR2765218A1 (fr) | 1998-12-31 |
NZ500212A (en) | 2001-07-27 |
AU731887B2 (en) | 2001-04-05 |
CA2285479A1 (en) | 1999-01-14 |
NO996496D0 (no) | 1999-12-27 |
EP0993436A1 (en) | 2000-04-19 |
FR2765218B1 (fr) | 1999-08-13 |
PL337665A1 (en) | 2000-08-28 |
KR20010014294A (ko) | 2001-02-26 |
JP2002508776A (ja) | 2002-03-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |