HUP0001604A3 - The preparation of an enantiomerically-enriched threo-methylphenidate - Google Patents
The preparation of an enantiomerically-enriched threo-methylphenidateInfo
- Publication number
- HUP0001604A3 HUP0001604A3 HU0001604A HUP0001604A HUP0001604A3 HU P0001604 A3 HUP0001604 A3 HU P0001604A3 HU 0001604 A HU0001604 A HU 0001604A HU P0001604 A HUP0001604 A HU P0001604A HU P0001604 A3 HUP0001604 A3 HU P0001604A3
- Authority
- HU
- Hungary
- Prior art keywords
- methylphenidate
- enantiomerically
- preparation
- threo
- enriched
- Prior art date
Links
- DUGOZIWVEXMGBE-OLZOCXBDSA-N methyl (S)-phenyl[(R)-piperidin-2-yl]acetate Chemical compound C([C@@H]1[C@@H](C(=O)OC)C=2C=CC=CC=2)CCCN1 DUGOZIWVEXMGBE-OLZOCXBDSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9625972.6A GB9625972D0 (en) | 1996-12-13 | 1996-12-13 | Bioresolution |
| GBGB9712298.0A GB9712298D0 (en) | 1997-06-12 | 1997-06-12 | Crystallisation |
| PCT/GB1997/003418 WO1998025902A1 (en) | 1996-12-13 | 1997-12-11 | The preparation of enantiomerically-enriched threo-methylphenidate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0001604A2 HUP0001604A2 (hu) | 2000-10-28 |
| HUP0001604A3 true HUP0001604A3 (en) | 2003-03-28 |
Family
ID=26310627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0001604A HUP0001604A3 (en) | 1996-12-13 | 1997-12-11 | The preparation of an enantiomerically-enriched threo-methylphenidate |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0948484A1 (hu) |
| JP (1) | JP2001506621A (hu) |
| AU (1) | AU7847098A (hu) |
| CA (1) | CA2272373A1 (hu) |
| CZ (1) | CZ206299A3 (hu) |
| HU (1) | HUP0001604A3 (hu) |
| NO (1) | NO992875L (hu) |
| PL (1) | PL334136A1 (hu) |
| WO (1) | WO1998025902A1 (hu) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6486177B2 (en) | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
| US6100401A (en) * | 1998-04-20 | 2000-08-08 | Novartris Ag | Process for preparing the d-threo isomer of methylphenidate hydrochloride |
| US6162919A (en) * | 1998-12-03 | 2000-12-19 | Novartis Ag | Process for preparing the d-threo isomer of methylphenidate hydrochloride |
| US6127385A (en) * | 1999-03-04 | 2000-10-03 | Pharmaquest Limited | Method of treating depression using l-threo-methylphenidate |
| US6395752B1 (en) * | 1999-03-04 | 2002-05-28 | Pharmaquest Limited | Method of treating depression using 1-threo-methylphenidate |
| US6025502A (en) * | 1999-03-19 | 2000-02-15 | The Trustees Of The University Of Pennsylvania | Enantopselective synthesis of methyl phenidate |
| US6221883B1 (en) * | 2000-04-12 | 2001-04-24 | Ross Baldessarini | Method of dopamine inhibition using l-threo-methylphenidate |
| DE60027282T2 (de) * | 2000-06-17 | 2007-04-12 | Pharmaquest Ltd., Hamilton | Verwendung von l-threo-methylphenidate zur Herstellung eines Medikaments für die Behandlung von Depression |
| WO2004080959A2 (en) * | 2003-03-07 | 2004-09-23 | Isp Investments Inc. | Process for the preparation of dexmethylphenidate hydrochloride |
| US7897777B2 (en) | 2007-01-05 | 2011-03-01 | Archimica, Inc. | Process of enantiomeric resolution of D,L-(±)-threo-methylphenidate |
| WO2010128517A1 (en) | 2009-05-07 | 2010-11-11 | Malladi Drugs & Pharmaceuticals Ltd. | Improved process for the preparation of d-threo-ritalinic acid hydrochloride by resolution of dl-threo-ritalinic acid using chiral carboxylic acid |
| JP5886869B2 (ja) | 2010-12-17 | 2016-03-16 | ローズ テクノロジーズ | メチルフェニデート塩酸塩の低温合成 |
| EP4011364B1 (en) | 2011-03-23 | 2023-12-13 | Ironshore Pharmaceuticals & Development, Inc. | Methods and compositions for treatment of attention deficit disorder |
| US9603809B2 (en) | 2011-03-23 | 2017-03-28 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
| US8916588B2 (en) | 2011-03-23 | 2014-12-23 | Ironshore Pharmaceuticals & Development, Inc. | Methods for treatment of attention deficit hyperactivity disorder |
| US9283214B2 (en) | 2011-03-23 | 2016-03-15 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US9498447B2 (en) | 2011-03-23 | 2016-11-22 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US10905652B2 (en) | 2011-03-23 | 2021-02-02 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US10292937B2 (en) | 2011-03-23 | 2019-05-21 | Ironshore Pharmaceuticals & Development, Inc. | Methods of treatment of attention deficit hyperactivity disorder |
| US9119809B2 (en) | 2011-03-23 | 2015-09-01 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US11241391B2 (en) | 2011-03-23 | 2022-02-08 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US8927010B2 (en) | 2011-03-23 | 2015-01-06 | Ironshore Pharmaceuticals & Development, Inc. | Compositions for treatment of attention deficit hyperactivity disorder |
| US9233924B2 (en) | 2014-03-11 | 2016-01-12 | Ampac Fine Chemicals Llc | Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof |
| US10081597B2 (en) | 2014-06-27 | 2018-09-25 | Embio Limited | Process for preparation of dexmethylphenidate hydrochloride |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02190195A (ja) * | 1989-01-19 | 1990-07-26 | Rikagaku Kenkyusho | 光学活性プロピオン酸エステル類化合物の製法 |
| JPH02273196A (ja) * | 1989-03-08 | 1990-11-07 | Wisconsin Alumni Res Found | ラセミ化合物の生体触媒分割のエナンチオ選択性の改良法 |
| JP3431204B2 (ja) * | 1993-04-22 | 2003-07-28 | 塩野義製薬株式会社 | ノルボルナン型エステル・ヒドロラーゼ |
| BE1007297A3 (nl) * | 1993-07-19 | 1995-05-09 | Dsm Nv | Werkwijze voor de bereiding van optisch aktieve alcoholen en esters, en alcoholen en esters toegepast en bereid in dergelijke werkwijzen. |
| DE4420751A1 (de) * | 1994-06-15 | 1995-12-21 | Basf Ag | Verfahren zur Herstellung von enantiomerenreinen Lactamen |
-
1997
- 1997-12-11 CA CA002272373A patent/CA2272373A1/en not_active Abandoned
- 1997-12-11 JP JP52637898A patent/JP2001506621A/ja active Pending
- 1997-12-11 EP EP97949034A patent/EP0948484A1/en not_active Withdrawn
- 1997-12-11 AU AU78470/98A patent/AU7847098A/en not_active Abandoned
- 1997-12-11 PL PL97334136A patent/PL334136A1/xx unknown
- 1997-12-11 HU HU0001604A patent/HUP0001604A3/hu unknown
- 1997-12-11 CZ CZ992062A patent/CZ206299A3/cs unknown
- 1997-12-11 WO PCT/GB1997/003418 patent/WO1998025902A1/en not_active Application Discontinuation
-
1999
- 1999-06-11 NO NO992875A patent/NO992875L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO992875L (no) | 1999-06-14 |
| NO992875D0 (no) | 1999-06-11 |
| CA2272373A1 (en) | 1998-06-18 |
| HUP0001604A2 (hu) | 2000-10-28 |
| PL334136A1 (en) | 2000-02-14 |
| JP2001506621A (ja) | 2001-05-22 |
| WO1998025902A1 (en) | 1998-06-18 |
| CZ206299A3 (cs) | 1999-09-15 |
| AU7847098A (en) | 1998-07-03 |
| EP0948484A1 (en) | 1999-10-13 |
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