PL334136A1 - Method of obtaining enantiomerically enriched methyl threophenidate - Google Patents

Method of obtaining enantiomerically enriched methyl threophenidate

Info

Publication number
PL334136A1
PL334136A1 PL97334136A PL33413697A PL334136A1 PL 334136 A1 PL334136 A1 PL 334136A1 PL 97334136 A PL97334136 A PL 97334136A PL 33413697 A PL33413697 A PL 33413697A PL 334136 A1 PL334136 A1 PL 334136A1
Authority
PL
Poland
Prior art keywords
threophenidate
enantiomerically enriched
obtaining enantiomerically
enriched methyl
methyl
Prior art date
Application number
PL97334136A
Inventor
Susan Faulconbridge
Hooshang Shahriari Zavareh
Graham Robert Evans
Marianne Langston
Original Assignee
Medeva Europ Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625972.6A external-priority patent/GB9625972D0/en
Priority claimed from GBGB9712298.0A external-priority patent/GB9712298D0/en
Application filed by Medeva Europ Ltd filed Critical Medeva Europ Ltd
Publication of PL334136A1 publication Critical patent/PL334136A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL97334136A 1996-12-13 1997-12-11 Method of obtaining enantiomerically enriched methyl threophenidate PL334136A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9625972.6A GB9625972D0 (en) 1996-12-13 1996-12-13 Bioresolution
GBGB9712298.0A GB9712298D0 (en) 1997-06-12 1997-06-12 Crystallisation
PCT/GB1997/003418 WO1998025902A1 (en) 1996-12-13 1997-12-11 The preparation of enantiomerically-enriched threo-methylphenidate

Publications (1)

Publication Number Publication Date
PL334136A1 true PL334136A1 (en) 2000-02-14

Family

ID=26310627

Family Applications (1)

Application Number Title Priority Date Filing Date
PL97334136A PL334136A1 (en) 1996-12-13 1997-12-11 Method of obtaining enantiomerically enriched methyl threophenidate

Country Status (9)

Country Link
EP (1) EP0948484A1 (en)
JP (1) JP2001506621A (en)
AU (1) AU7847098A (en)
CA (1) CA2272373A1 (en)
CZ (1) CZ206299A3 (en)
HU (1) HUP0001604A3 (en)
NO (1) NO992875L (en)
PL (1) PL334136A1 (en)
WO (1) WO1998025902A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486177B2 (en) 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US6100401A (en) * 1998-04-20 2000-08-08 Novartris Ag Process for preparing the d-threo isomer of methylphenidate hydrochloride
US6162919A (en) * 1998-12-03 2000-12-19 Novartis Ag Process for preparing the d-threo isomer of methylphenidate hydrochloride
US6395752B1 (en) * 1999-03-04 2002-05-28 Pharmaquest Limited Method of treating depression using 1-threo-methylphenidate
US6127385A (en) * 1999-03-04 2000-10-03 Pharmaquest Limited Method of treating depression using l-threo-methylphenidate
US6025502A (en) * 1999-03-19 2000-02-15 The Trustees Of The University Of Pennsylvania Enantopselective synthesis of methyl phenidate
US6221883B1 (en) * 2000-04-12 2001-04-24 Ross Baldessarini Method of dopamine inhibition using l-threo-methylphenidate
EP1163907B1 (en) * 2000-06-17 2006-04-12 Pharmaquest Limited Use of l-threo-methylphenidate for the manufacture of a medicament for the treatment of depression
WO2004080959A2 (en) * 2003-03-07 2004-09-23 Isp Investments Inc. Process for the preparation of dexmethylphenidate hydrochloride
US7897777B2 (en) 2007-01-05 2011-03-01 Archimica, Inc. Process of enantiomeric resolution of D,L-(±)-threo-methylphenidate
WO2010128517A1 (en) 2009-05-07 2010-11-11 Malladi Drugs & Pharmaceuticals Ltd. Improved process for the preparation of d-threo-ritalinic acid hydrochloride by resolution of dl-threo-ritalinic acid using chiral carboxylic acid
KR101561361B1 (en) 2010-12-17 2015-10-16 로드스 테크놀로지즈 Low-temperature synthesis of methylphenidate hydrochloride
US9498447B2 (en) 2011-03-23 2016-11-22 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9119809B2 (en) 2011-03-23 2015-09-01 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9603809B2 (en) 2011-03-23 2017-03-28 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
US9283214B2 (en) 2011-03-23 2016-03-15 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US11241391B2 (en) 2011-03-23 2022-02-08 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
EP3272342B1 (en) 2011-03-23 2021-05-26 Ironshore Pharmaceuticals & Development, Inc. Methods and compositions for treatment of attention deficit disorder
US8927010B2 (en) 2011-03-23 2015-01-06 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US8916588B2 (en) 2011-03-23 2014-12-23 Ironshore Pharmaceuticals & Development, Inc. Methods for treatment of attention deficit hyperactivity disorder
US10292937B2 (en) 2011-03-23 2019-05-21 Ironshore Pharmaceuticals & Development, Inc. Methods of treatment of attention deficit hyperactivity disorder
US10905652B2 (en) 2011-03-23 2021-02-02 Ironshore Pharmaceuticals & Development, Inc. Compositions for treatment of attention deficit hyperactivity disorder
US9233924B2 (en) 2014-03-11 2016-01-12 Ampac Fine Chemicals Llc Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof
JP2017519832A (en) 2014-06-27 2017-07-20 エンビオ リミテッド Novel method for the synthesis of optically pure β-aminoalcohols

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02190195A (en) * 1989-01-19 1990-07-26 Rikagaku Kenkyusho Production of optically active propionic acid ester compound
JPH02273196A (en) * 1989-03-08 1990-11-07 Wisconsin Alumni Res Found Method for improving enantio-selectivity in biocatalytic resolution of racemic compound
JP3431204B2 (en) * 1993-04-22 2003-07-28 塩野義製薬株式会社 Norbornane type ester hydrolase
BE1007297A3 (en) * 1993-07-19 1995-05-09 Dsm Nv OPTICAL METHOD FOR THE PREPARATION OF ACTIVE alcohols and esters, alcohols and esters APPLIED AND WILLING TO SUCH METHODS.
DE4420751A1 (en) * 1994-06-15 1995-12-21 Basf Ag Process for the preparation of enantiomerically pure lactams

Also Published As

Publication number Publication date
NO992875L (en) 1999-06-14
JP2001506621A (en) 2001-05-22
EP0948484A1 (en) 1999-10-13
NO992875D0 (en) 1999-06-11
CZ206299A3 (en) 1999-09-15
WO1998025902A1 (en) 1998-06-18
HUP0001604A2 (en) 2000-10-28
HUP0001604A3 (en) 2003-03-28
CA2272373A1 (en) 1998-06-18
AU7847098A (en) 1998-07-03

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